Back to resultsInvestigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism (KIPLING)
Primary Purpose
Hypertrophy
Status
Recruiting
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Krill oil
Krill protein
Vegetable oil
Carbohydrate
Sponsored by
About this trial
This is an interventional treatment trial for Hypertrophy focused on measuring Omega-3, Krill oil, Protein, Exercise
Eligibility Criteria
Inclusion Criteria: Be 60 years old or older Have a BMI of less than 35kg/m2 Be participating in structured exercise for less than 2h per week Exclusion Criteria: Diabetes Severe cardiovascular disease Seizure disorders, Uncontrolled hypertension (>150/90mmHg at baseline measurement) Cancer or cancer that has been in remission <5 years Ambulatory impairments which would limit ability to perform assessments of muscle function Dementia Taking medication known to affect muscle (e.g., steroids) Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump), Anticoagulant therapy Allergies to seafood Regular consumption of more than 1 portion of oily fish per week.
Sites / Locations
- Stuart Robert GrayRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
Placebo Comparator
Experimental
Experimental
Experimental
Arm Label
Vegetable oil + Carbohydrate
Vegetable oil + Krill protein
Krill oil + Carbohydrate
Krill oil + Krill protein
Arm Description
The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g)
The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)
Outcomes
Primary Outcome Measures
Post-exercise muscle protein synthesis
Muscle protein synthesis measured 3-7h after a single bout of resistance exercise
Secondary Outcome Measures
Change in Muscle thickness
Vastus lateralis muscle thickness measured by ultrasound
Change in grip strength
Grip strength measured with a Jamar dynamometer
Change in fat mass
Whole body fat mass measured by BIA
Change in lean mass
Whole body lean mass measured by BIA
Change in muscle strength
Knee extensor muscle strength measured isometrically
Change in Chair rise time
Time taken to get up and down from a chair 5 times
Change in balance
Ability to stand for 10 seconds in full tandem, semi-tandem and feet together
Change in gait speed
Time taken to walk 4 metres at a normal walking pace
Basal muscle protein synthesis
Muscle protein synthesis measured from 0-3h after an overnight fast
Change in Erythrocyte fatty acid profile
Erythrocyte fatty acid profile
Full Information
NCT ID
NCT05774444
First Posted
March 7, 2023
Last Updated
May 8, 2023
Sponsor
University of Glasgow
Collaborators
Aker BioMarine
1. Study Identification
Unique Protocol Identification Number
NCT05774444
Brief Title
Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism
Acronym
KIPLING
Official Title
Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism: a Randomised Controlled Trial
Study Type
Interventional
2. Study Status
Record Verification Date
May 2023
Overall Recruitment Status
Recruiting
Study Start Date
May 1, 2023 (Actual)
Primary Completion Date
December 25, 2024 (Anticipated)
Study Completion Date
December 25, 2024 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Glasgow
Collaborators
Aker BioMarine
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hypertrophy
Keywords
Omega-3, Krill oil, Protein, Exercise
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Parallel 2x2 factorial design
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
All supplements with be colour and flavour matched
Allocation
Randomized
Enrollment
48 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Vegetable oil + Carbohydrate
Arm Type
Placebo Comparator
Arm Description
The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
Arm Title
Vegetable oil + Krill protein
Arm Type
Experimental
Arm Description
The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g)
Arm Title
Krill oil + Carbohydrate
Arm Type
Experimental
Arm Description
The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)
Arm Title
Krill oil + Krill protein
Arm Type
Experimental
Arm Description
Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)
Intervention Type
Dietary Supplement
Intervention Name(s)
Krill oil
Intervention Description
Krill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation.
Intervention Type
Dietary Supplement
Intervention Name(s)
Krill protein
Intervention Description
Krill protein will be given to the participant following a resistance exercise bout.
Intervention Type
Dietary Supplement
Intervention Name(s)
Vegetable oil
Intervention Description
This will be the control against the Krill oil
Intervention Type
Dietary Supplement
Intervention Name(s)
Carbohydrate
Intervention Description
This will be the control for the Krill protein
Primary Outcome Measure Information:
Title
Post-exercise muscle protein synthesis
Description
Muscle protein synthesis measured 3-7h after a single bout of resistance exercise
Time Frame
3-7 hours
Secondary Outcome Measure Information:
Title
Change in Muscle thickness
Description
Vastus lateralis muscle thickness measured by ultrasound
Time Frame
Change from baseline to 8 weeks
Title
Change in grip strength
Description
Grip strength measured with a Jamar dynamometer
Time Frame
Change from baseline to 8 weeks
Title
Change in fat mass
Description
Whole body fat mass measured by BIA
Time Frame
Change from baseline to 8 weeks
Title
Change in lean mass
Description
Whole body lean mass measured by BIA
Time Frame
Change from baseline to 8 weeks
Title
Change in muscle strength
Description
Knee extensor muscle strength measured isometrically
Time Frame
Change from baseline to 8 weeks
Title
Change in Chair rise time
Description
Time taken to get up and down from a chair 5 times
Time Frame
Change from baseline to 8 weeks
Title
Change in balance
Description
Ability to stand for 10 seconds in full tandem, semi-tandem and feet together
Time Frame
Change from baseline to 8 weeks
Title
Change in gait speed
Description
Time taken to walk 4 metres at a normal walking pace
Time Frame
Change from baseline to 8 weeks
Title
Basal muscle protein synthesis
Description
Muscle protein synthesis measured from 0-3h after an overnight fast
Time Frame
0-3 hours
Title
Change in Erythrocyte fatty acid profile
Description
Erythrocyte fatty acid profile
Time Frame
Change from baseline to 8 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
60 Years
Maximum Age & Unit of Time
90 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Be 60 years old or older
Have a BMI of less than 35kg/m2
Be participating in structured exercise for less than 2h per week
Exclusion Criteria:
Diabetes
Severe cardiovascular disease
Seizure disorders,
Uncontrolled hypertension (>150/90mmHg at baseline measurement)
Cancer or cancer that has been in remission <5 years
Ambulatory impairments which would limit ability to perform assessments of muscle function
Dementia
Taking medication known to affect muscle (e.g., steroids)
Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
Anticoagulant therapy
Allergies to seafood
Regular consumption of more than 1 portion of oily fish per week.
Facility Information:
Facility Name
Stuart Robert Gray
City
Glasgow
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stuart R Gray
Phone
01413302569
Email
stuart.gray@glasgow.ac.uk
Phone
01413302569
Ext
Gray
Email
stuart.gray@glasgow.ac.uk
First Name & Middle Initial & Last Name & Degree
Stuart R Gray, PhD
12. IPD Sharing Statement
Plan to Share IPD
No
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Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism
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