Involved-Field Radiation Therapy in Treating Patients With Previously Untreated Stage I or Stage II Low-Grade Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage I grade 1 follicular lymphoma, stage I grade 2 follicular lymphoma, stage I grade 3 follicular lymphoma, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, contiguous stage II small lymphocytic lymphoma, contiguous stage II marginal zone lymphoma, noncontiguous stage II small lymphocytic lymphoma, noncontiguous stage II marginal zone lymphoma, nodal marginal zone B-cell lymphoma, stage I marginal zone lymphoma, stage I small lymphocytic lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage I or II, low-grade, non-Hodgkin's lymphoma Follicular lymphoma grade I, II, or III Small lymphocytic lymphoma Lymphoplasmacytoid lymphoma Nodal marginal zone lymphoma Previously untreated disease At least 1 measurable or evaluable mass at least 1.1 cm (except for patients with stage I disease where the entire mass was removed for diagnostic purposes) NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: WBC greater than 2,000/mm ^3 Platelet count greater than 100,000/mm^3 Hepatic: Not specified Renal: Not specified Other: No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix No psychological, familial, sociological, or geographical condition that would preclude study participation Not pregnant or nursing Fertile patients must use effective contraception HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy Not specified Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified Other No other concurrent anticancer therapy
Sites / Locations
- U.Z. Gasthuisberg
- Universitair Medisch Centrum St. Radboud - Nijmegen
- University Hospital Rebro
- Rigshospitalet - Copenhagen University Hospital
- National Cancer Institute of Egypt
- Centre D'Oncologie Du Pays-Basque
- Institut Bergonie
- Centre Hospitalier de Dax
- Hopital Robert Boulin
- Polyclinique Francheville
- Medisch Spectrum Twente
- University Medical Center Groningen
- Maastro Clinic - Locatie Maastricht
- Daniel Den Hoed Cancer Center at Erasmus Medical Center
- Dr. Bernard Verbeeten Instituut