Iressa (ZD1839) Plus Anastrozole (Arimidex) in Patients With Ovarian Cancer

Inclusion Criteria: Histologic or cytologic history diagnosis of primary ovarian, primary peritoneal or tubal carcinoma Asymptomatic from ovarian cancer Evidence of recurrent ovarian, peritoneal or tubal carcinoma Tumor sample must be positive for ER and/or PR 18 years of age or older ECOG performance status of less than or equal to 1 Must be able to tolerate oral intake Exclusion Criteria: Known hypersensitivity to Iressa or any of the excipients of this product Other coexisting malignancies or malignancies diagnosed within the last 5 years Concomitant use of phenytoin, carbamazepine, barbiturates, rifampicin, phenobarbital or St. John's wort Treatment with a non-approved or investigational drug within 30 days Any unresolved chronic toxicity greater than CTC grad 2 from previous anticancer therapy (except alopecia) Incomplete healing from previous oncologic or other major surgery Serum creatinine level greater than CTC grade 2 Pregnant or breast feeding Severe uncontrolled systemic disease Significant clinical disorder or laboratory finding that makes it potentially unsafe for the subject to participate Patients currently receiving other investigational antineoplastic agents, on systemic chemotherapy or under radiation therapy treatment Patients previously treated with anastrozole or other aromatase inhibitor Unable to tolerate oral medications Clinical and/or radiographic evidence of current or impending bowel obstruction