Irinotecan, Carboplatin, Bevacizumab, and Radiation Therapy in the Treatment of Limited Stage Small Cell Lung Cancer

Inclusion Criteria: Histologically-confirmed small cell lung cancer. Limited stage disease ( ECOG performance status 0 or 1. No previous treatment with chemotherapy, radiation therapy, or biologic agents. Measurable disease Adequate bone marrow, liver, kidney function Patients must be able to understand the nature of this study and give written consent. Exclusion Criteria: Age < 18 years History of a prior malignancy within three years with the exception of skin cancer (excluding melanoma), cervical carcinoma in situ, in situ breast carcinoma, or early stage prostate cancer. Women who are pregnant or lactating are ineligible. Men and women of childbearing potential are required to use adequate contraception during this study. History or physical exam evidence of CNS disease (eg seizures not controlled with standard medical therapy, history of stroke) Active infection requiring parenteral antibiotics Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, or fine needle aspiration within 7 days of beginning bevacizumab or anticipation of need for major surgical procedure during the course of the study. Full-dose oral or parenteral anticoagulation must be on a stable dosing schedule prior to enrollment. Proteinuria Serious nonhealing wound, ulcer, or bone fracture Evidence of bleeding diathesis or coagulopathy Prior hemoptysis. History of acute myocardial infarction or stroke within 6 months Uncontrolled hypertension (> 150/100), unstable angina, New York Heart Association grade II or greater CHF, serious cardiac arrhythmia requiring medication, or grade II or greater peripheral vascular disease. Received other investigational drugs within 28 days PEG, G-tubes, or other percutaneous drains/tubes History of any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates use of an investigational drug or that might affect interpretation of the results of the study or place the subject at high risk for treatment complications History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the previous 6 months