Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease
Coronary Artery Disease
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring arteries, blood flow, coronary artery disease, diet
Eligibility Criteria
Inclusion Criteria: Aged 30-75 years Patients requiring diagnostic coronary angiography Presence of coronary artery disease on angiogram but with at least one non-obstructed (lesions <70% narrowed compared with the adjacent normal part of the vessel) atheromatous vessel (confirmed at diagnostic cardiac catheterisation) Female patients must be postmenopausal (FSH>40 IU/L) Willing to give informed, written consent Exclusion Criteria: Age <30 or >75 years Allergy to radiographic contrast media Sino-atrial disease or significant bradycardia Concomitant medication with persantin (dipyridamole) or theophyllines Asthma Hypertension Left ventricular hypertrophy or dysfunction (clinical/ECG/echo/CXR) Female patients with FSH<40 IU/L (postmenopausal) Female patients currently taking hormone therapy, or who have taken hormone therapy in previous 6 months Unwilling to give written informed consent Participation in another study within previous 60 days
Sites / Locations
- Royal Brompton & Harefield NHS Trust
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Genistein
Placebo
Supro drink once daily for 3 days
Drink identical to Supro but containing no genistein, once daily for 3 days