Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures
Non Epileptic Seizures, Functional Neurological Symptom Disorder, Conversion Disorder
About this trial
This is an interventional treatment trial for Non Epileptic Seizures
Eligibility Criteria
Inclusion Criteria:
- Patients who have a record at the institute and who have a diagnosis of a dissociative neurological symptom disorder with non-epileptic seizures with a certainty of at least clinically established who have a monthly seizure frequency greater than 3.
- Patients with the characteristics described above with comorbid epilepsy but who have not presented epileptic seizures in the last month.
- Patients with the aforementioned characteristics and who give their informed consent in writing to participate in the study.
- Patients who, once the diet has been explained to them, consider it feasible to implement it at least for the follow-up time.
Exclusion Criteria:
- Patients with metabolic or hemodynamic instability, liver failure, inability to tolerate the oral route, acute pancreatitis or pregnancy due to the possible teratogenic effect that has not yet been elucidated.
- Patients with metabolic disorders such as primary carnitine deficiency, palmitoyltransferase carnitine I or II deficiency, carnitine translocase deficiency, beta oxidation defects, pyruvate carboxylase deficiency, porphyria and other fatty acid transport and oxidation disorders.
Sites / Locations
- Instituto Nacional de Neurologia Y Neurocirugia Mvs
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
ketogenic dieting + conventional treatment
Healthy dieting + conventional treatment
Nutrition team will help patients implement an Atkins-type ketogenic diet. The diet should be continued for at least 6 weeks. They will be able to continue with the pharmacological-based treatment but without any changes having been made in the last 6 weeks or during the time they are in the study. To ensure adherence to the diet, urine ketones will be determined twice a week.
In addition to their basic (pharmacological) treatment, the nutrition team will help them implement a low-calorie, non-ketogenic diet. The presence of ketones will also be determined in urine to avoid bias