L-Arginine Metabolism in Essential Hypertension

Inclusion Criteria: Males, ages 18-65 Male and female healthy control subjects ages 18-65 Exclusion Criteria: Any other coexisting condition Advanced damage of vital organs (grade III und IV retinopathy) Therapy with a not approved concomitant medication in the last 4 weeks prior to intake of the first trial medication, especially lipid lowering and antidiabetic medications (washout phase) Blood donation within the last 4 weeks Patients with arterial fibrillation or atrioventricular (AV)-block (II and more) Patients with anamnestic myocardial infarct Patients with depression Patients with seizure disorders Patients with unstable angina pectoris including electrocardiogram (ECG)-aberrations or cardiac insufficiency New York Heart Association (NYHA) Stadium III and IV History of a malignant illness with the exception of those patients who have recovered for more than 10 years or have a basalioma of the skin. Actual or anamnestic alcohol or drug abuse History of organ transplant Anaphylaxis or known therapy resistance to any of the used test matters. Therapy with a not approved concomitant therapy Participation in another study within three months prior to study inclusion Illnesses, which can influence the pharmacodynamics or pharmacokinetics of the test substance Liver or kidney diseases: SGOT, GPT , γ-GT, AP, bilirubin and creatinine above 200% of standard Patients who are not sufficiently compliant; or patients who are not capable or willing to appear for controlling visits. Severe or unstable medical or psychiatric illnesses, which will, in the estimation of the examiner, endanger the safety of the proband or the successful participation in the study Presumed risk of transmission of HIV or hepatitis via blood from the proband