Laboratory-Treated Lymphocyte Infusion After Haploidentical Donor Stem Cell Transplant

This is an interventional treatment trial for Leukemia focused on measuring refractory anemia with excess blasts in transformation, adult acute lymphoblastic leukemia in remission, refractory anemia with excess blasts, refractory anemia, adult acute myeloid leukemia in remission, childhood acute lymphoblastic leukemia in remission, childhood acute myeloid leukemia in remission, de novo myelodysplastic syndromes, previously treated myelodysplastic syndromes, secondary acute myeloid leukemia, adult acute myeloid leukemia with 11q23 (MLL) abnormalities, adult acute myeloid leukemia with inv(16)(p13;q22), adult acute myeloid leukemia with t(15;17)(q22;q12), adult acute myeloid leukemia with t(16;16)(p13;q22), adult acute myeloid leukemia with t(8;21)(q22;q22), secondary myelodysplastic syndromes, childhood myelodysplastic syndromes Read More

DISEASE CHARACTERISTICS:

• Diagnosis of 1 of the following:

  • Acute lymphocytic leukemia

    • In ≥ second complete remission (CR), defined as < 5% blasts in bone marrow (BM) and no active extramedullary disease OR in first CR with any of the following high risk features:

      • History of induction failure
      • Philadelphia chromosome positive
      • t(4;11) by cytogenetic analysis
      • Any infant with MLL rearrangements on cytogenetic analysis
    • No relapse with isolated extramedullary disease after completion of prior treatment

  • Acute myeloid leukemia

    • Failed induction therapy after < 3 courses

    • In ≥ second CR, defined as < 5% blasts in BM and no active extramedullary disease OR in first CR with any of the following high-risk features:

      • History of induction failure = 5q- or monosomy 7 cytogenetic findings

  • Any of the following myelodysplastic syndromes:

    • Refractory anemia (RA) with excess blasts (RAEB) with a high International Prognostic Scoring System (IPSS) score or score of intermediate-1(INT-1) or intermediate-2 (INT-2)
    • RAEB in transformation with INT-1, INT-2, or high IPSS score
    • RA with INT-2 score

• Patients must have a healthy, related donor who is at least genotypically HLA-A, B, C, and DR haploidentical to the patient

  • No suitably matched family donor defined by genotypic or phenotypic identity for ≥ 5/6 A, B, or DR loci
  • No immediately available genotypically matched (6/6) unrelated marrow donor
  • No immediately available umbilical cord blood donor with suitable cell dose after a search ≥ 2 months
  • Patients whose medical condition is at high risk of deteriorating or whose disease is at high risk of progression during a donor search are eligible
• Has a parent with a haplotype that is disparate from that of the donor for the haplotype shared by the patient and parent, but not shared by the patient and donor OR patient is able to donate sufficient autologous cells by peripheral blood draw or unstimulated leukapheresis
• No active CNS disease

PATIENT CHARACTERISTICS:

• Room air O_2 saturation > 95% unless the lungs are involved with disease
• No clinical evidence of pulmonary insufficiency unless the lungs are involved with disease
• AST and ALT < 3 times upper limit of normal (ULN)*
• Bilirubin < 2.0 mg/dL*
• Creatinine < 2 times ULN OR creatinine clearance or glomerular filtration rate > 50% of the lower limit of normal
• LVEF > 45% OR shortening fraction > 20%
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No active infection, defined as absence of an infectious diagnosis or (in patients who have had a recent positive infectious diagnosis) the resolution of fever, documentation of negative cultures or antigen testing, continuation or completion of a course of appropriate therapy, and presence of stable to resolving clinical symptoms
• No evidence of HIV infection OR known HIV positivity NOTE: *Does not apply if liver is involved with disease

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• No prior stem cell transplantation
• No other concurrent immunosuppressive therapy