Leiden Trial In Prevention of Post-Operative ThromboEmbolic Events (TIPOTEE)
Deep-Venous Thrombosis
About this trial
This is an interventional prevention trial for Deep-Venous Thrombosis
Eligibility Criteria
Inclusion Criteria:• Intracranial surgery;
- Tumour surgery (spinal or intracranial);
- >180 min estimated surgical intervention time;
- >240 min time under anaesthesia;
- Spine trauma surgery;
Exclusion Criteria:
• Age under 18 years;
- Perioperative continuation of anti coagulant therapy indicated other than prophylactic LMWH;
Sites / Locations
- Leiden University Medical CentreRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Fraxiparine
IPD
Intervention: All patients receive Fraxiparine 2850 IE daily, starting preoperatively compatible with current practice. After randomization the patients in this arm will be subjected to fraxipareine 2850 IE daily. According to current guidelines in the LUMC the Fraxiparine dose is doubled to 5600 IE in patients with a weight above 100 kg.
Intervention: IPD Device: After randomization the patients in this arm will be subjected to fraxiparine 2850 IE daily and intermittent pressure devices for at least 48 hours or until mobilization. The intermittent pressure device is a leg pump delivered by Converis(R).