Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors

Inclusion Criteria: Patients with a histological diagnosis of a primary CNS tumor (including histologically benign brain tumors (e.g. low-grade glioma) that is recurrent, progressive, or refractory to standard therapy; patients with intrinsic brain stem or diffuse optic pathway tumors do not require histological confirmation of disease but should have clinical and/or radiographic evidence of progression Karnofsky Performance Scale (KPS for >= 16 yrs of age) or Lansky Performance Score (LPS for ≤ 16 years of age) ≥ 60 assessed within two weeks prior to registration Patient must be able to swallow capsules Patients must have recovered from any significant acute toxicity associated with prior therapy; patients must have no known curative therapy available; patients will be eligible regardless of the number of prior therapies, as long as other eligibility criteria are met Chemo: Prior use of thalidomide is acceptable; patients must have: Received their last dose of known myelosuppressive anticancer chemotherapy or biological therapy at least three (3) weeks prior to study registration Received their last dose of nitrosourea or mitomycin-C at least six (6) weeks prior to study registration Received their last dose of other investigational agent or an anticancer drug known to not be myelosuppressive at least seven (7) days prior to study registration XRT: Patients must have had their last fraction of craniospinal irradiation ≥ 3 months prior to registration and their last fraction of local irradiation to primary tumor ≥ 4 weeks prior to registration Bone Marrow Transplant: ≥ 6 months since allogeneic bone marrow transplant and ≥ 3 months since autologous bone marrow/stem cell prior to registration Growth factors: Off all colony forming growth factor(s) > 2 weeks prior to registration (filgrastim, sargramostim, erythropoietin) The following laboratory values must be assessed within two (2) weeks prior to registration and again within seven (7) days prior to the start of therapy; laboratory tests should be repeated within 48 hours of beginning therapy if there has been a significant clinical change Absolute neutrophil count ≥ 1000/μl (unsupported) Platelets ≥ 100,000/μl (unsupported) Hemoglobin ≥ 8.0 g/dL (may be supported) Serum creatinine within upper limit of institutional normal for age Or GFR ≥ 70 ml/min/1.73m^2 Bilirubin ≤ 1.5 times upper limit of normal for age SGPT (ALT) ≤ 2.5x institutional upper limit of normal for age Albumin ≥ 2 g/dL No overt renal, hepatic, cardiac or pulmonary disease Female patients of childbearing potential must have negative serum or urine pregnancy test (sensitivity of at least 50mIU/ml); patients must not be pregnant or breast-feeding All sexually active females must begin 2 methods of birth control, including 1 highly effective method, and 1 additional method (at the same time) at least 4 weeks prior to the first dose of CC-5013; this applies to all sexually active females of childbearing potential unless they have not had a menstrual period in 2 years or have undergone a hysterectomy Patients of child fathering potential must agree to use latex condoms during intercourse with a woman while taking CC-5013 and for 4 weeks thereafter Signed informed consent according to institutional guidelines must be obtained Exclusion Criteria: Patients with a body surface area (BSA) ≤ 0.4 m^2 are excluded Patients with a first-degree relative with a history of venous thrombosis before age 50 yrs or an arterial thrombosis before age 40 yrs are excluded Patients who have had a thromboembolic event that is not line-related are excluded Patients with any significant medical illnesses that, in the investigator's opinion, cannot be adequately controlled with appropriate therapy or would compromise a patient's ability to tolerate this therapy Patients with any disease that would obscure toxicity or dangerously alter drug metabolism Patients receiving any other chemotherapeutics or investigational agents Patients with uncontrolled infection Patients unable to swallow capsules Patients with known hypersensitivity to anhydrous lactose, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate