Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy
Periodontitis

About this trial
This is an interventional treatment trial for Periodontitis focused on measuring In situ gel, High Performance Thic Layer Chromatography, Local Drug Delivery
Eligibility Criteria
Inclusion Criteria: Patients with ages ranging from 25 to 50 years old. Localized periodontitis, probing depth ≥5 mm. Less than 30% of teeth are involved. Both genders. Patients must be able to return for the recall visits and agreed to sign the written consent after a full explanation of the study. Systemically free according to the American Society of Anesthesiologists (ASA I). Exclusion Criteria: Smokers Pregnant and lactating women or oral contraceptive usage Prisoners or abused individuals Unwilling patients to perform oral hygiene measures of plaque control. Patients with a history of allergy against any components of the two materials. Previous Periodontal treatment or any use of antibiotic/anti-inflammatory drugs within the last 6 months before the initiation of the study.
Sites / Locations
- Faculty of Dentitry, Ain Shams University
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Lepidium sativum
simvastatin
15 participants 15 participants with localized stage II or III, and grade A periodontitis received about 2ml of locally delivered Lepidium sativum in situ gel with scaling and root surface debridement once at the beginning of the study
15 participants with localized stage II or III, and grade A periodontitis received about 1.2% of locally delivered Simvastatin in situ gel with scaling and root surface debridement once at the beginning of the study