Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.
Frozen Embryo Transfer, Polycystic Ovarian Disease, Letrozole
About this trial
This is an interventional treatment trial for Frozen Embryo Transfer
Eligibility Criteria
Inclusion Criteria:
- Women with PCOS diagnosed with Rotterdam criteria.
- Age between 20 to 40-year-old
- Undergoing frozen oocytes intracytoplasmic sperm injection transfer or frozen embryo transfer
- Willingly accept to participate in the study
Exclusion Criteria:
- Women > 40 years old or younger than 20.
Uterine pathology that decreases the chance of pregnancy or increases risk of miscarriage such as
- Uterine fibroids (sub-mucous of any size or intramural of > 3 cm)
Uncontrolled endocrinal-pathological disease like
- Cushing syndrome,
- Adrenal hyperplasia,
- Hyperprolactinemia,
- Acromegaly,
- Thyroid disease,
- Diabetes mellitus, and
- Immune disorders.
- Presence of Hydrosalpinx
- Not willing or able to sign the consent form.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
PCOS women will receive letrozole ovarian stimulation.
PCOS women will receive Estradiol and Progesterone (hormonal endometrial preparation).
Polycystic ovarian disease (PCOS) women undergoing frozen embryo transfer (FER) will use Letrozole 5 mg starting on day 3 of spontaneous menstrual period or after progesterone withdrawal bleeding for five consecutive days.
PCOS women will use daily Cetorelix acetate 0.25 mg injections for 5 days from day 1-3 of the menstrual follow or after progesterone (P4) withdrawal bleeding. They will commence daily oral Estradiol Valerate (E2) 2 mg twice daily for 5 days starting from day 3 of the menstrual flow or after P4 withdrawal bleeding, then-after three times daily. When endometrial thickness reaches 7 mm or more, the dose of E2 will be reduced to 4 mg/ day. Women will start using vaginal micronized P4 100 mg three times daily starting from 8PM. After 48 hours of starting the vaginal P4, oral Dydrogesterone 10 mg three times daily will commence.