Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Solid Tumors, Hematologic Malignancies
About this trial
This is an interventional treatment trial for Solid Tumors focused on measuring PD1, PD-1, PDL1, PD-L1
Eligibility Criteria
Inclusion Criteria:
- Treated on the parent pembrolizumab studies established by the Sponsor as MK-3475-587 ready
- Currently receiving pembrolizumab or in a follow-up phase
Additional eligibility criteria for participants who enter Second Course Phase once they are enrolled on MK-3475-587:
- Has not received any anticancer systemic treatment since the last dose of pembrolizumab or a pembrolizumab-based combination in First Course Phase
- Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Demonstrates adequate organ function
- Have resolution of any toxic effect(s) of First Course Phase trial treatment with pembrolizumab or a pembrolizumab-based combination to Grade 1 or less (except alopecia) before trial treatment in Second Course Phase is started. If participant received major surgery or radiation therapy of >30 Gray (Gy), they must have recovered from the toxicity and/or complications of the intervention.
- A female participant is eligible to enroll if she is not pregnant, not breastfeeding, and ≥1 of the following conditions applies: A woman of childbearing potential (WOCBP) who agrees to use contraception during the study treatment period and for ≥120 days (corresponding to time needed to eliminate any study combination treatment(s) plus 30 days (a menstruation cycle) for study treatments with risk of genotoxicity.
Exclusion Criteria:
-There are no exclusion criteria to participate in MK-3475-587.
Participants are excluded from entering Second Course trial treatment once they are enrolled on MK-3475-587 if any of the following criteria applies:
- Has severe hypersensitivity (≥ Grade 3) to pembrolizumab and/or any of its excipients
- Has received a live vaccine within 30 days prior to the first dose of Second Course Phase trial treatment
- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the Cycle 1 Day 1 of Second Course Phase
- Has a known additional malignancy that is progressing or requires active treatment. Exceptions include early stage cancers (carcinoma in situ or Stage 1) treated with curative intent, melanoma (non-ulcerated, thin primary), basal cell carcinoma of the skin, squamous cell carcinoma of the skin, in situ cervical cancer, or in situ breast cancer that has undergone potentially curative therapy.
- Has known active central nervous system metastases and/or carcinomatous meningitis
- Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed.
- Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis. Note: Participants that experienced pneumonitis during First Course that did not meet the criteria for permanent discontinuation are eligible.
- Non-small cell lung cancer (NSCLC) participants only: Has interstitial lung disease
- Has an active infection requiring systemic therapy
- Has a known history of human immunodeficiency virus (HIV) infection.
- Has a known history of or is positive for hepatitis B or hepatitis C. For parent studies where inclusion of participants with hepatitis was permitted, MK-3475-587 will follow the parent study eligibility criteria for hepatitis.
- Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the Second Course Phase eligibility Visit through 120 days after the last dose of study treatment.
- Has severe cardiovascular disease, i.e., arrhythmias, requiring chronic treatment, congestive heart failure (New York Heart Association Class III or IV) or symptomatic ischemic heart disease.
- Has hepatic decompensation (Child-Pugh score >6 [class B and C])
- Has uncontrolled thyroid dysfunction
- Has uncontrolled diabetes mellitus
- Has had an allogeneic tissue/solid organ transplant
- Has a known history of active tuberculosis (TB; Bacillus tuberculosis)
Sites / Locations
- University of Arizona Cancer Center ( Site 0018)Recruiting
- Comprehensive Blood & Cancer Center [Bakersfield, CA] ( Site 0054)Recruiting
- California Cancer Associates for Research & Excellence ( Site 0016)
- The Angeles Clinic and Research Institute ( Site 0005)
- UCLA Hematology/Oncology - Westwood (Building 100) ( Site 0009)Recruiting
- UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0004)Recruiting
- Providence Saint John's Health Center ( Site 0059)Recruiting
- University of Colorado Cancer Center ( Site 0021)Recruiting
- Yale Cancer Center ( Site 0014)Recruiting
- Georgetown University Medical Center ( Site 0023)Recruiting
- Holy Cross Hospital, Michael & Dianne Bienes Comp Cancer Ctr ( Site 0022)Recruiting
- Mount Sinai Medical Center Comprehensive Cancer Center ( Site 0031)Recruiting
- Moffitt Cancer Center ( Site 0011)Recruiting
- Emory School of Medicine ( Site 0013)
- Northwest Georgia Oncology Centers PC ( Site 0061)Recruiting
- Kaiser Permanente Moanalua Medical Center ( Site 0063)Recruiting
- The University of Chicago ( Site 0020)Recruiting
- University of Iowa Hospital and Clinics ( Site 0026)Recruiting
- James Graham Brown Cancer Center ( Site 0058)Recruiting
- MedStar Franklin Square Medical Center ( Site 0046)Recruiting
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0056)Recruiting
- Massachusetts General Hospital ( Site 0041)Recruiting
- Dana-Farber Cancer Institute ( Site 0006)Recruiting
- Karmanos Cancer Institute ( Site 0047)Recruiting
- Mayo Clinic in Rochester, Minnesota ( Site 0002)Recruiting
- Comprehensive Cancer Centers of Nevada ( Site 0043)Recruiting
- John Theurer Cancer Center at Hackensack University Medical Center ( Site 0038)
- Cancer Institute of New Jersey ( Site 0025)Recruiting
- Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0032)Recruiting
- Memorial Sloan Kettering Cancer Center ( Site 0012)Recruiting
- White Plains Hospital-Center for Cancer Care ( Site 0069)Recruiting
- University of North Carolina at Chapel Hill ( Site 0040)Recruiting
- Levine Cancer Institute ( Site 0034)Recruiting
- Duke Cancer Center ( Site 0028)Recruiting
- Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0065)Recruiting
- University Hospitals ( Site 0044)Recruiting
- Providence Portland Medical Center ( Site 0051)Recruiting
- St. Luke's University Health Network ( Site 0017)Recruiting
- University of Pennsylvania ( Site 0010)Recruiting
- Fox Chase Cancer Center ( Site 0042)Recruiting
- UPMC Hillman Cancer Center ( Site 0008)Recruiting
- Sanford Cancer Center ( Site 0066)Recruiting
- West Cancer Center and Research Institute ( Site 0055)Recruiting
- Vanderbilt Health One Hundred Oaks Diagnostic ( Site 0060)Recruiting
- Vanderbilt Ingram Cancer Center ( Site 0015)Recruiting
- Texas Oncology-Baylor Sammons Cancer Center ( Site 0062)Recruiting
- University of Texas MD Anderson Cancer Center ( Site 0007)Recruiting
- South Texas Accelerated Research Therapeutics, LLC (START) ( Site 0001)Recruiting
- University of Virginia Health System ( Site 0035)Recruiting
- Blue Ridge Cancer Care ( Site 0067)Recruiting
- Seattle Cancer Care Alliance ( Site 0024)Recruiting
- Hospital Aleman-Oncology ( Site 1351)Recruiting
- Clinica Viedma ( Site 1353)Recruiting
- Sanatorio Parque ( Site 1355)Recruiting
- Instituto de Oncologia de Rosario ( Site 1350)Recruiting
- Hospital Privado Universitario de Córdoba ( Site 1354)Recruiting
- Centro Medico San Roque-Oncology ( Site 1352)Recruiting
- Chris OBrien Lifehouse ( Site 3003)Recruiting
- Royal Prince Alfred Hospital-A.W. Morrow Gastroenterology and Liver Centre ( Site 3016)Recruiting
- Liverpool Hospital-Medical Oncology ( Site 3021)Recruiting
- Macquarie University ( Site 3010)Recruiting
- Mater Hospital Sydney ( Site 3007)Recruiting
- Orange Hospital-Clinical Trials Unit ( Site 3027)Recruiting
- Port Macquarie - Mid North Coast Cancer Institute-Medical Oncology ( Site 3020)Recruiting
- Royal North Shore Hospital-Medical Oncology Clinical Trials ( Site 3025)Recruiting
- Calvary Mater Newcastle ( Site 3005)Recruiting
- Westmead Hospital ( Site 3000)Recruiting
- Melanoma Institute Australia ( Site 3001)Recruiting
- Mater Misericordiae Limited-Medical Oncology ( Site 3019)Recruiting
- Gallipoli Medical Research Foundation ( Site 3011)Recruiting
- Royal Brisbane and Women s Hospital ( Site 3009)Recruiting
- Tasman Oncology Research Pty Ltd ( Site 3012)Recruiting
- The Townsville Hospital ( Site 3017)Recruiting
- Princess Alexandra Hospital ( Site 3002)Recruiting
- Royal Adelaide Hospital ( Site 3014)Recruiting
- The Queen Elizabeth Hospital ( Site 3026)Recruiting
- Monash Health ( Site 3015)Recruiting
- Austin Health-Austin Hospital ( Site 3004)Recruiting
- Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3008)Recruiting
- St Vincent's Hospital-Oncology Clinical Trials ( Site 3018)Recruiting
- Western Health-Sunshine & Footscray Hospitals ( Site 3023)Recruiting
- Ballarat Oncology & Haematology Services ( Site 3022)Recruiting
- Sir Charles Gairdner Hospital ( Site 3006)Recruiting
- St John of God Subiaco Hospital ( Site 3013)Recruiting
- Kepler Universitätsklinikum ( Site 2955)Recruiting
- Medical University of Graz ( Site 2952)Recruiting
- Medizinische Universitaet Innsbruck ( Site 2951)Recruiting
- Uniklinikum Salzburg ( Site 2956)Recruiting
- Medizinische Universität Wien ( Site 2953)
- Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2954)Recruiting
- AZ Sint-Maarten ( Site 2904)Recruiting
- Institut Jules Bordet ( Site 2903)Recruiting
- UZ Brussel ( Site 2900)Recruiting
- Cliniques Universitaires de Bruxelles - CUB - Hopital Erasme ( Site 2905)Recruiting
- AZ Maria Middelares ( Site 2908)Recruiting
- UZ Leuven ( Site 2901)Recruiting
- UZ Leuven - Campus Gasthuisberg ( Site 2906)Recruiting
- UZ Leuven Gasthuisberg, Gynaecologie-Verloskunde ( Site 2907)Recruiting
- ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 1008)Recruiting
- Hospital de Clinicas de Porto Alegre ( Site 1000)Recruiting
- Hospital São Lucas da PUCRS-Centro de Pesquisa em Oncologia ( Site 1006)Recruiting
- Hospital Nossa Senhora da Conceição ( Site 1011)Recruiting
- Clinica Viver ( Site 1021)Recruiting
- CEPON ( Site 1012)Recruiting
- Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1010)Recruiting
- Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( SiteRecruiting
- Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA ( Site 1020)Recruiting
- Instituto de de Educação, pesquisa e Gestão em Saúde ( Site 1014)Recruiting
- Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1001)Recruiting
- A. C. Camargo Cancer Center ( Site 1002)Recruiting
- Cross Cancer Institute ( Site 2804)Recruiting
- Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2801)Recruiting
- Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2808)Recruiting
- London Regional Cancer Program - LHSC ( Site 2806)Recruiting
- Sunnybrook Research Institute ( Site 2802)Recruiting
- Mount Sinai Hospital ( Site 2811)Recruiting
- Princess Margaret Cancer Centre ( Site 2803)Recruiting
- Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre-Oncology ( Site 2809)Recruiting
- Centre Intégré de Santé et de Services Sociaux (CISSS) de La-Centre intégré de cancérologie de LavaRecruiting
- Centre Hospitalier de l Universite de Montreal - CHUM ( Site 2807)Recruiting
- Jewish General Hospital ( Site 2800)Recruiting
- Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 2Recruiting
- Orlandi Oncologia-Oncology ( Site 2752)
- Fundacion Arturo Lopez Perez FALP ( Site 2750)Recruiting
- Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 2751)Recruiting
- Instituto Nacional del Cancer-CR Investigación ( Site 2753)Recruiting
- Bradfordhill-Clinical Area ( Site 2756)Recruiting
- Centro de Investigaciones ( Site 2755)Recruiting
- Anhui Provincial Hospital-Cancer Chemotherapy Department ( Site 3480)Recruiting
- Anhui Provincil Hospital South District-Respiratory Medicine Dept ( Site 3487)Recruiting
- Beijing Cancer Hospital ( Site 3451)Recruiting
- Affiliated Hospital of Military Medical Science Academy of the PLA ( Site 3465)Recruiting
- Beijing Cancer hospital-Thoracic Cancer Department A ( Site 3454)Recruiting
- Beijing Peking Union Medical College Hospital-Medical Oncology ( Site 3466)Recruiting
- Army Medical Center of People's Liberation Army-Oncology Department ( Site 3477)Recruiting
- Fujian Provincial Cancer Hospital ( Site 3461)Recruiting
- SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal Medicine ( Site 3452)Recruiting
- Sun Yat-sen University Cancer Center-melanoma ( Site 3482)Recruiting
- Guangdong Provincial People's Hospital-Cancer Center ( Site 3462)Recruiting
- The First Affiliated Hospital, Sun Yat-sen University-pneumology department ( Site 3459)Recruiting
- The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 346Recruiting
- Harbin Medical University Cancer Hospital-Harbin Medical University Cancer Hospital ( Site 3475)Recruiting
- Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 3476)Recruiting
- Xiangya Hospital Central South University-Respiratory ( Site 3479)Recruiting
- Northern Jiangsu People's Hospital-General Surgery Department ( Site 3474)Recruiting
- The First Hospital of Jilin University-Oncology ( Site 3464)Recruiting
- Jilin Province Tumor Hospital ( Site 3484)Recruiting
- Tangdu Hospital of Fourth Military Medical University of Chi-department of radiotherapy ( Site 3455)Recruiting
- Fudan University Shanghai Cancer Center ( Site 3467)Recruiting
- Shanghai Pulmonary Hospital ( Site 3470)Recruiting
- West China Hospital Sichuan University-respiratory ( Site 3473)Recruiting
- Tianjin Medical University Cancer Institute and Hospital ( Site 3456)Recruiting
- Hangzhou Cancer Hospital-Medical Oncology ( Site 3468)Recruiting
- Zhejiang Cancer Hospital ( Site 3481)Recruiting
- Instituto de Cancerología-Oncology ( Site 2702)
- Oncomédica S.A.S ( Site 2703)Recruiting
- Administradora Country S.A. ( Site 2701)Recruiting
- Fundacion Valle del Lili ( Site 2700)Recruiting
- Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0703)Recruiting
- Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0704)Recruiting
- Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 0702)Recruiting
- Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0705)Recruiting
- Fakultni nemocnice Olomouc ( Site 0701)Recruiting
- Fakultni nemocnice v Motole ( Site 0700)Recruiting
- Odense Universitetshospital ( Site 0650)Recruiting
- Vejle Sygehus ( Site 0653)Recruiting
- Tartu University Hospital-Radiotherapy and oncology ( Site 3800)Recruiting
- Tampere University Hospital [Tampere Finland] ( Site 0600)Recruiting
- Turku University Hospital ( Site 0601)Recruiting
- Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 2539)Recruiting
- Nouvel Hôpital Civil (NHC) ( Site 2529)Recruiting
- CHU Bordeaux Haut-Leveque ( Site 2534)Recruiting
- Centre Hopitalar Leon-Berard ( Site 2519)Recruiting
- Hopital Nord ( Site 2516)Recruiting
- CHU La Timone ( Site 2508)Recruiting
- C.H.U. de Tours - Hopital Bretonneau ( Site 2515)Recruiting
- CHU Jean Minjoz ( Site 2520)
- CHU de Brest -Site Hopital Morvan ( Site 2504)Recruiting
- Institut Bergonie ( Site 2502)Recruiting
- CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 2526)Recruiting
- CHU Toulouse - Hopital Rangueil ( Site 2518)Recruiting
- Ambroise Pare Hopital ( Site 2503)Recruiting
- Hôpital Beaujon ( Site 2524)Recruiting
- Groupe hospitalier Paris saint Joseph-Service de Pneumologie-Allergologie -Oncologie Thoracique ( SiRecruiting
- Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 2525)Recruiting
- Hopital Trousseau ( Site 2512)Recruiting
- Institut de Cancérologie de l'Ouest-Oncologie Médicale ( Site 2522)Recruiting
- Institut de Cancérologie de Lorraine Alexis Vautrin ( Site 2532)Recruiting
- CHRU Lille Hospital Claude Huriez ( Site 2506)Recruiting
- CH Lyon Sud Hospices Civils de Lyon ( Site 2521)Recruiting
- C.H.U. Pontchaillou ( Site 2511)Recruiting
- Centre Hospitalier du Mans-Pneumologie ( Site 2527)Recruiting
- Centre Hopitalier Intercommunal Creteil ( Site 2514)Recruiting
- Institut Gustave Roussy ( Site 2513)Recruiting
- Hopital Cochin ( Site 2509)Recruiting
- Hopital Saint Louis ( Site 2510)Recruiting
- CHU Hopital Saint Antoine ( Site 2517)Recruiting
- Hôpital Tenon ( Site 2530)Recruiting
- Universitaetsklinikum Tuebingen ( Site 2405)Recruiting
- Universitätsklinikum Erlangen ( Site 2408)
- Universitaetsklinik Muenchen ( Site 2406)
- Krankenhaus Nordwest ( Site 2409)Recruiting
- Elbe Klinikum Buxtehude ( Site 2400)Recruiting
- Medizinische Hochschule Hannover ( Site 2402)
- Universitaetsklinikum Essen ( Site 2404)
- Universitaetsklinikum des Saarlandes ( Site 2411)Recruiting
- Universitatsklinikum Carl Gustav Carus ( Site 2407)Recruiting
- LungenClinic Grosshansdorf GmbH ( Site 2412)Recruiting
- SRH Wald-Klinikum Gera GmbH ( Site 2403)Recruiting
- Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 2418)Recruiting
- Facharztzentrum Eppendorf ( Site 2415)Recruiting
- Sotiria Regional Chest Diseases Hospital of Athens ( Site 1850)
- Oncomedica ( Site 3401)Recruiting
- Grupo Medico Angeles-Grupo Medico Angeles ( Site 3402)Recruiting
- MEDI-K CAYALA ( Site 3403)Recruiting
- Queen Mary Hospital ( Site 1902)Recruiting
- Queen Mary Hospital-Department of Medicine (Respiratory) ( Site 1900)Recruiting
- Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Megyei Onkológiai Centrum ( Site 1405)Recruiting
- Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház ( Site 1409)Recruiting
- Fejér Megyei Szent György Egyetemi Oktató Kórház-l.Pulmonologia ( Site 1407)Recruiting
- Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1401)Recruiting
- Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1411)Recruiting
- Markusovszky Egyetemi Oktatokorhaz-Onkológiai Osztály ( Site 1410)Recruiting
- Farkasgyepui Tudogyogyintezet-Pulmonologia ( Site 1414)Recruiting
- Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1406)Recruiting
- Orszagos Koranyi Pulmonologiai Intezet ( Site 1403)Recruiting
- Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 1413)Recruiting
- Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 1415)Recruiting
- Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1412)Recruiting
- Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1402)Recruiting
- Zala Megyei Szent Rafael Korhaz ( Site 1400)Recruiting
- Mater Misercordiae University Hospital ( Site 1800)Recruiting
- Tallaght University Hospital ( Site 1803)Recruiting
- St. James s Hospital ( Site 1801)Recruiting
- Rambam Health Care Campus-Oncology Division ( Site 2053)Recruiting
- Hadassah Ein Kerem Medical Center ( Site 2051)Recruiting
- Rabin Medical Center ( Site 2059)Recruiting
- Chaim Sheba Medical Center ( Site 2055)Recruiting
- Chaim Sheba Medical Center. ( Site 2052)Recruiting
- Sourasky Medical Center ( Site 2054)Recruiting
- Shamir Medical Center Assaf Harofeh ( Site 2058)
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1975)Recruiting
- Policlinico Universitario Agostino Gemelli ( Site 1965)Recruiting
- Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1968)Recruiting
- Ospedale San Luigi Gonzaga ( Site 1956)
- IRCCS CRO Aviano, Hematology/Oncology ( Site 1957)Recruiting
- Istituto di Candiolo - IRCCS ( Site 1960)Recruiting
- AO Santa Maria della Misericordia-Oncology Department ( Site 1971)Recruiting
- Humanitas Gavazzeni ( Site 1954)Recruiting
- Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-UOC Oncologia ( Site 1967)Recruiting
- Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1972)Recruiting
- IRCCS A.O.U. San Martino - IST ( Site 1961)Recruiting
- Istituto Europeo di Oncologia ( Site 1952)Recruiting
- Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1955)
- Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 1964)Recruiting
- Azienda Ospedaliera San Camillo Forlanini ( Site 1958)Recruiting
- ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 1969)Recruiting
- Azienda Ospedaliera Santa Maria ( Site 1962)Recruiting
- Nagoya University Hospital ( Site 3151)Recruiting
- National Hospital Organization Nagoya Medical Center ( Site 3109)Recruiting
- Aichi Cancer Center Hospital ( Site 3101)Recruiting
- National Cancer Center Hospital East ( Site 3121)Recruiting
- National Hospital Organization Shikoku Cancer Center ( Site 3116)Recruiting
- Kurume University Hospital ( Site 3105)Recruiting
- Sapporo Medical University Hospital ( Site 3113)Recruiting
- Hokkaido University Hospital ( Site 3165)Recruiting
- Hyogo Cancer Center ( Site 3131)Recruiting
- National Hospital Organization Himeji Medical Center ( Site 3111)Recruiting
- Kobe City Medical Center General Hospital ( Site 3144)Recruiting
- Hyogo Medical University Hospital ( Site 3100)Recruiting
- Kanazawa University Hospital ( Site 3140)Recruiting
- Kitasato University Hospital ( Site 3142)Recruiting
- Yokohama City University Hospital ( Site 3163)Recruiting
- Kanagawa cancer center ( Site 3137)Recruiting
- Yokosukakyosai ( Site 3150)Recruiting
- Miyagi Cancer Center ( Site 3122)Recruiting
- Sendai Kousei Hospital ( Site 3115)Recruiting
- Nara Medical University Hospital ( Site 3110)Recruiting
- Kurashiki Central Hospital ( Site 3132)Recruiting
- Osaka Habikino Medical Center ( Site 3138)Recruiting
- Kansai Medical University Hospital ( Site 3126)Recruiting
- Kindai University Hospital- Osakasayama Campus ( Site 3166)Recruiting
- Kindai University Hospital ( Site 3102)Recruiting
- Kindai University Hospital- Osakasayama Campus-Department of Gastroenterology and Hepatology ( SiteRecruiting
- Osaka Rosai Hospital ( Site 3148)Recruiting
- Saitama Medical University International Medical Center ( Site 3118)Recruiting
- Saitama Cancer Center ( Site 3112)Recruiting
- Dokkyo Medical University - Koshigaya Hospital ( Site 3152)Recruiting
- Shizuoka Cancer Center ( Site 3128)Recruiting
- Jichi Medical University Hospital ( Site 3141)Recruiting
- Tokyo Medical and Dental University Hospital ( Site 3149)Recruiting
- Japanese Foundation for Cancer Research ( Site 3146)Recruiting
- Japanese Foundation for Cancer Research ( Site 3164)Recruiting
- Toranomon Hospital ( Site 3134)Recruiting
- Toranomon Hospital ( Site 3153)Recruiting
- Kyorin University Hospital ( Site 3103)Recruiting
- Kyorin University Hospital ( Site 3147)Recruiting
- National Hospital Organization Yamaguchi Ube Medical Center ( Site 3123)Recruiting
- Yamaguchi University Hospital ( Site 3114)Recruiting
- Chiba Cancer Center ( Site 3117)Recruiting
- National Hospital Organization Kyushu Medical Center ( Site 3136)Recruiting
- Kyushu University Hospital ( Site 3143)Recruiting
- Gifu University Hospital ( Site 3161)Recruiting
- Hiroshima City Hiroshima Citizens Hospital ( Site 3119)Recruiting
- Hiroshima University Hospital ( Site 3154)Recruiting
- Kochi Health Sciences Center ( Site 3145)Recruiting
- Okayama University Hospital ( Site 3107)Recruiting
- Osaka City General Hospital ( Site 3125)Recruiting
- National Hospital Organization - Osaka National Hospital - Institute For Clinical Research ( Site 31Recruiting
- Osaka International Cancer Institute-Gynecologic Oncology ( Site 3129)Recruiting
- National Cancer Center Hospital ( Site 3130)Recruiting
- St.Luke's International Hospital ( Site 3120)Recruiting
- Nippon Medical School Hospital ( Site 3139)Recruiting
- Tokyo Metropolitan Komagome Hospital ( Site 3133)Recruiting
- The Cancer Institute Hospital of JFCR ( Site 3108)Recruiting
- Keio University Hospital ( Site 3127)Recruiting
- Teikyo University Hospital ( Site 3104)Recruiting
- Wakayama Medical University Hospital ( Site 3124)Recruiting
- Chonnam National University Hwasun Hospital-Hemato-Oncology ( Site 0959)Recruiting
- National Cancer Center ( Site 0955)Recruiting
- CHA Bundang Medical Center CHA University ( Site 0957)Recruiting
- Seoul National University Bundang Hospital ( Site 0951)Recruiting
- Asan Medical Center ( Site 0952)Recruiting
- Chungnam national university hospital-Department of Internal Medicine ( Site 0958)Recruiting
- Korea University Anam Hospital ( Site 0956)Recruiting
- Seoul National University Hospital ( Site 0953)Recruiting
- Severance Hospital ( Site 0954)Recruiting
- Samsung Medical Center ( Site 0950)Recruiting
- Liepjas reionl slimnca ( Site 3851)Recruiting
- RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of ChRecruiting
- Klaipeda University Hospital-Oncology chemotherapy ( Site 3302)
- National Cancer Institute-Chemotherapy departament with day care unit ( Site 3301)Recruiting
- Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 3300)Recruiting
- Hospital Tengku Ampuan Afzan ( Site 0627)Recruiting
- Gleneagles Penang ( Site 0625)Recruiting
- University Malaya Medical Centre ( Site 0626)Recruiting
- INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1102)Recruiting
- Avix Investigación Clinica, S.C.-Oncology ( Site 1104)Recruiting
- Oaxaca Site Management Organization ( Site 1106)Recruiting
- Medical Care and Research SA de CV ( Site 1103)Recruiting
- Oncare Viaducto Napoles ( Site 1107)Recruiting
- Radboud University Medical Center ( Site 1554)Recruiting
- Antoni van Leeuwenhoek Ziekenhuis ( Site 1551)Recruiting
- Amsterdam UMC, locatie VUmc ( Site 1555)Recruiting
- Erasmus MC ( Site 1553)Recruiting
- Universitair Medisch Centrum Groningen ( Site 1550)Recruiting
- Canterbury Regional Cancer & Blood Service ( Site 1500)Recruiting
- Waikato Hospital ( Site 1502)Recruiting
- Auckland City Hospital ( Site 1503)Recruiting
- Capital & Coast District Health Board - Wellington Hospital ( Site 1501)Recruiting
- Helse Bergen Haukeland universitetssykehus ( Site 1451)Recruiting
- Oslo Universitetssykehus Radiumhospitalet ( Site 1450)Recruiting
- Oslo Universitetssykehus Ullevål-Avdeling for kreftbehandling, Ullevål ( Site 1452)Recruiting
- Hospital Cayetano Heredia-Oncology ( Site 0675)Recruiting
- Makati Medical Center ( Site 1702)Recruiting
- Lung Center of the Philippines ( Site 1705)Recruiting
- St. Luke s Medical Center ( Site 1700)Recruiting
- Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1612)Recruiting
- Powiatowe Centrum Zdrowia w Brzezinach Sp. z o. o. Oddział Dziennej Chemioterapii ( Site 1611)Recruiting
- Instytut Centrum Zdrowia Matki Polki-Klinika Onkologii ( Site 1609)Recruiting
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Oddzial w Krakowie ( Site 1608)Recruiting
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (Recruiting
- Wojskowy Instytut Medyczny-Klinika Onkologii ( Site 1606)Recruiting
- Bialostockie Centrum Onkologii ( Site 1610)Recruiting
- Przychodnia Lekarska KOMED ( Site 1603)Recruiting
- Med-Polonia Sp. z o. o. ( Site 1605)Recruiting
- Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w PoznaRecruiting
- Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1614)Recruiting
- Champalimaud Foundation ( Site 1751)
- Centro Hospitalar Lisboa Norte E.P.E. - Hospital Pulido Valente ( Site 1750)
- Instituto Português de Oncologia do Porto Francisco Gentil, EPE-Oncologia Médica ( Site 1753)
- Centro Hospitalar de Sao Joao - Hospital de Sao Joao ( Site 1752)
- Ad-Vance Medical Research-Research ( Site 1151)Recruiting
- FDI Clinical Research ( Site 1152)Recruiting
- UPR Comprehensive Cancer Center ( Site 1150)
- Spitalul Județean Sfântul Ioan cel Nou Suceava-Oncology ( Site 3550)Recruiting
- Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1204)
- Bashkir State Medical University ( Site 1221)Recruiting
- Belgorod Oncology Dispensary ( Site 1213)
- Regional Budgetary Healthcare Institution 'Ivanovo Regional Oncology Dispensary'-Urology ( Site 1219Recruiting
- GBUZ LOKB ( Site 1218)Recruiting
- GBUZ LOKB-Oncology department #1 ( Site 1222)Recruiting
- Ogarev Mordovia State University ( Site 1206)
- The National Medico-Surgical Center N.I. Pirogov ( Site 1225)Recruiting
- N.N. Blokhin NMRCO ( Site 1209)
- Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1201)
- Russian Scientific Center of Roentgenoradiology ( Site 1215)
- P. A. Hertsen Moscow Oncology Research Center ( Site 1214)Recruiting
- FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 1208)
- N.N.Petrov Research Institute of Oncology-Department of Preclinical and Clinical Research ( Site 121
- Clinical Research Center of specialized types medical care-Oncology ( Site 1205)
- GBUZ SK Pyatigorsk Interdistrict Oncology dispensary ( Site 1223)Recruiting
- Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1203)
- SAIH of the Tyumen region, Multidisciplinary Clinical Medical Center "Medical town" ( Site 1220)Recruiting
- Udmurtian Republican Clinical Oncology Center ( Site 1212)Recruiting
- National Cancer Centre Singapore ( Site 2200)Recruiting
- National University Hospital-Haematology -Oncology Research Group ( Site 2201)Recruiting
- Wits Clinical Research ( Site 2002)Recruiting
- LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2005)Recruiting
- Wilgers Oncology Centre ( Site 2006)Recruiting
- Sandton Oncology Medical Group (Pty) Ltd-Research ( Site 2004)Recruiting
- The Oncology Centre ( Site 2000)Recruiting
- Cape Town Oncology Trials ( Site 2007)Recruiting
- GVI Oncology ( Site 2008)Recruiting
- Hospital Universitario Virgen de la Victoria ( Site 0878)Recruiting
- Hospital Universitario Central de Asturias-Medical Oncology ( Site 0870)Recruiting
- Hospital Universitari Son Espases-Oncologia ( Site 0883)Recruiting
- Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0860)Recruiting
- H. Marques de Valdecilla ( Site 0865)Recruiting
- Hospital Clinic de Barcelona ( Site 0852)Recruiting
- Hospital de la Santa Creu i Sant Pau-Oncología Médica ( Site 0862)Recruiting
- CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 0876)Recruiting
- Hospital Universitario Insular de Gran Canaria ( Site 0867)Recruiting
- Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 0877)Recruiting
- Hospital Universitario Puerta de Hierro-Majadahonda ( Site 0861)Recruiting
- Hospital Universitario Quiron Madrid ( Site 0868)Recruiting
- H.R.U Málaga - Hospital General ( Site 0884)Recruiting
- Hospital Universitari Sant Joan de Reus-Oncology ( Site 0874)Recruiting
- Instituto Valenciano de Oncologia - IVO ( Site 0863)Recruiting
- Hospital Clinico de Valencia ( Site 0858)Recruiting
- Hospital General Universitario de Valencia ( Site 0854)Recruiting
- Hospital Arnau de Vilanova ( Site 0866)
- Hospital Universitari i Politecnic La Fe ( Site 0875)Recruiting
- Hospital General Universitario de Alicante-Oncologia ( Site 0881)Recruiting
- Parc de Salut Mar - Hospital del Mar-Oncologia ( Site 0873)Recruiting
- H.U. Vall de Hebron ( Site 0850)Recruiting
- Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0851)Recruiting
- Complejo Hospitalario de Jaén-Servicio de Oncología Médica ( Site 0879)Recruiting
- Hospital Universitario Gregorio Maranon ( Site 0864)Recruiting
- Clinica Universitaria de Navarra ( Site 0855)Recruiting
- Hospital Clinico San Carlos ( Site 0857)Recruiting
- Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 0871)Recruiting
- Hospital General Universitario 12 de Octubre ( Site 0856)Recruiting
- Hospital Universitario La Paz ( Site 0853)Recruiting
- Centro Integral Oncologico Clara Campal-Hospital HM Universitario Sanchinarro-START Madrid, ( Site 0Recruiting
- Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 0880)Recruiting
- HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 0872)Recruiting
- Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 0882)Recruiting
- Hospital Clinico Universitario Lozano Blesa ( Site 0859)Recruiting
- Karolinska Universitetssjukhuset Solna ( Site 0802)Recruiting
- Blod och Tumorssjukdomar. Akademiska sjukhuset ( Site 0801)Recruiting
- Norrlands Universitetssjukhus ( Site 0800)Recruiting
- University Hospital Basel ( Site 0752)Recruiting
- Hôpitaux Universitaires de Genève (HUG) ( Site 0753)Recruiting
- Universitaetsspital Zuerich ( Site 0750)Recruiting
- Kaohsiung Chang Gung Memorial Hospital ( Site 3203)Recruiting
- China Medical University Hospital ( Site 3204)Recruiting
- National Cheng Kung University Hospital ( Site 3201)Recruiting
- National Taiwan University Hospital ( Site 3200)Recruiting
- Mackay Memorial Hospital ( Site 3205)Recruiting
- Taipei Veterans General Hospital ( Site 3202)Recruiting
- Chang Gung Medical Foundation-Linkou Branch ( Site 3206)Recruiting
- Chulalongkorn University ( Site 2363)Recruiting
- Ramathibodi Hospital ( Site 2364)Recruiting
- Faculty of Medicine Siriraj Hospital ( Site 2365)Recruiting
- Acibadem Altunizade Hospital-Oncology ( Site 1317)Recruiting
- Acibadem Adana Hospital-Pediatric Hematology-Oncology ( Site 1312)Recruiting
- Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1307)Recruiting
- Ankara University Hospital Cebeci ( Site 1306)Recruiting
- Hacettepe Universitesi-oncology hospital ( Site 1304)Recruiting
- Baskent Universitesi Ankara Hastanesi ( Site 1303)Recruiting
- Ankara City Hospital-Medical Oncology ( Site 1311)Recruiting
- Memorial Antalya Hospital-Oncology ( Site 1315)Recruiting
- Trakya Universitesi Tip Fakultesi ( Site 1301)Recruiting
- Bezmialem Vakf Üniversitesi-Oncology ( Site 1308)Recruiting
- Istanbul University Capa Campus ( Site 1314)Recruiting
- Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1302)Recruiting
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1316)Recruiting
- Marmara Universitesi Pendik Egitim Arastirma Hastanesi-Medical Oncology ( Site 1305)Recruiting
- Ege Universitesi Tip Fakultesi Hastanesi ( Site 1300)Recruiting
- I.E.U. Medical Point Hastanesi-Oncology ( Site 1310)
- Kocaeli Üniversitesi ( Site 1313)Recruiting
- Inonu Universitesi ( Site 1309)Recruiting
- Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council ( Site 3650)Recruiting
- MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional-Chemotherapy department ( Site 3657)Recruiting
- Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk RegRecruiting
- CNPE "Regional Center of Oncology" ( Site 3665)Recruiting
- Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 3656)
- National Cancer Institute-Department of Minimally Invasive and Endoscopic Surgery, Interventional RRecruiting
- Municipal non-profit enterprise "Kyiv City Clinical Oncology Center" of executive body of Kyiv City
- Municipal institution of Lviv regional council Lviv Oncology-Chemotherapy ( Site 3653)Recruiting
- Odessa Regional Oncology Center ( Site 3655)Recruiting
- Transcarpathian Regional Clinical Oncology Center-Chemotherapy dept. ( Site 3652)
- Western General Hospital ( Site 0502)Recruiting
- The Christie ( Site 0516)Recruiting
- Weston Park Hospital ( Site 0519)Recruiting
- Mid Essex Hospitals Service Trust. Broomfield Hospital ( Site 0503)
- The Beatson West of Scotland Cancer Centre ( Site 0506)Recruiting
- Royal Preston Hospital ( Site 0518)Recruiting
- Barts Health NHS Trust ( Site 0512)Recruiting
- University College London Hospital-Cancer Clinical Trials Unit ( Site 0520)Recruiting
- Royal Free Hospital ( Site 0507)
- Royal Marsden Hospital ( Site 0505)
- Sarah Cannon Research UK ( Site 0504)
- Belfast City Hospital ( Site 0508)Recruiting
- Nottingham University Hospitals NHS Trust ( Site 0510)Recruiting
- St James University Hospital ( Site 0509)Recruiting
- The Royal Marsden NHS Foundation Trust. ( Site 0513)Recruiting
- New Cross Hospital-Department of Oncology ( Site 0517)Recruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Active Comparator
Pembrolizumab 200 mg
Pembrolizumab 400 mg
Pembrolizumab 200 mg + SOC: Per Parent Study)
Pembrolizumab 400 mg + SOC (Per Parent Study)
SOC (Per Parent Study)
Participants receive pembrolizumab 200 mg via intravenous (IV) infusion on Day 1 of each 3-week cycle for up to 35 administrations or more for First Course participants and up to 17 administrations for Second Course participants.
Participants receive pembrolizumab 400 mg via intravenous (IV) infusion on Day 1 of each 6-week cycle for up to 17 administrations or more for First Course participants and up to 8 administrations for Second Course participants.
Participants receive pembrolizumab 200 mg via IV infusion on Day 1 of each 3-week cycle PLUS standard of care (SOC) treatment (or per parent study if there is no SOC) for up to 35 administrations or more for First Course participants and up to 17 administrations for Second Course participants. Participants receiving a pembrolizumab-based combination treatment will receive the dose regimen of the combination drug(s) which is recommended per SOC or was used in the parent study protocol if there is no SOC recommendation.
Participants receive pembrolizumab 400 mg via IV infusion on Day 1 of each 6-week cycle PLUS SOC treatment (or per parent study if there is no SOC) for up to 17 administrations or more for First Course participants and up to 8 administrations for Second Course participants. Participants receiving a pembrolizumab-based combination treatment will receive the dose regimen of the combination drug(s) which is recommended per SOC or was used in the parent study protocol if there is no SOC recommendation.
Participants receive the dose matched non-pembrolizumab SOC treatment (e.g. chemotherapy) they were receiving as per parent study protocol.