Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women
Weight Loss, Gut Microbiome, Anti-Aging
About this trial
This is an interventional treatment trial for Weight Loss
Eligibility Criteria
Inclusion Criteria:
- Non-smoking, healthy, but overweight/obese men and women with no known cardiovascular or metabolic diseases as assessed by a medical history and a comprehensive medical examination by their physicians
- Sedentary or lightly active (<30 min, 2d/wk of structured physical activity) as assessed by a Physical Activity questionnaire
- Overweight or obese (BMI>27.5 kg/m2; % body fat>30%)
- Weight stable (+/-2kg) for at least 6 months prior to beginning the study
Exclusion Criteria:
- Type II Diabetes
- Emphysema
- Significant heart disease (CABG, CHF, VFib, Hypercholesterolemia, Uncontrolled High Blood Pressure, etc.)
- COPD
- Cancer or undergoing treatment for cancer
- Allergies to milk or milk products, sugar alcohols, fructose, or gluten
- Anorexia or Bulimia
- Fasting intolerances/hypoglycemia
- Pregnant or plan to become pregnant during 8-week study
Sites / Locations
- Human Nutrition and Metabolism Laboratory
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Protein pacing and intermittent fasting
Heart Healthy
During the 8-week weight loss (WL) phase, participants assigned to the P-IF will consist of P days, whereby female participants will consume four and male participants will consume five meals/snacks total, two of which (breakfast and lunch) will include a protein powder meal replacement mixed with water (240-400 kcals per meal) along with an evening dinner meal (~500 kcals), an afternoon snack (men only), and an evening snack (250 kcals). Subjects will be calorie restricted to ~1500 and ~1800 calories per day, women and men, respectively during P days. For each IF day, subjects will be provided a variety of supplements/snacks made by Isagenix International LLC. The P-IF group will be further divided into two subgroups for weeks 1-4. One subgroup will consist of five days of P and two days of IF, and the second subgroup will consist of six days of P and one day of IF. For weeks 5-8 both subgroups will follow 6 days of a P diet and 1 day IF.
The HH group will observe the dietary guidelines in compliance with the National Cholesterol Education Program Therapeutic Lifestyle Changes (TLC) diet. This diet consists of consuming <35% of kcal as fat; 50%-60% of kcal as carbohydrates; <200 mg/dL of dietary cholesterol; and 20-30 g/day of fiber. The total calorie intake will be 1200 and 1500 calories per day, women and men, respectively during the weight loss phase (weeks 0-8).