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Low Versus High-glycemic Index Post-exercise Diets for Improving Metabolism and Body Composition

Primary Purpose

Hypercholesterolemia

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Low glycemic index post-exercise diet
High glycemic index post-exercise diet
Sponsored by
University of Saskatchewan
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Hypercholesterolemia

Eligibility Criteria

18 Years - 44 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Overweight or obese (BMI 25 or greater)

Exclusion Criteria:

  • Smokers
  • Diabetic
  • Taking medications that affect carbohydrate or lipid metabolism

Sites / Locations

  • University of Saskatchewan

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Low glycemic index post-exercise diet

High glycemic index post-exercise diet

Arm Description

Lentil-based post-exercise meal

Instant potato, white bread, and egg white post-exercise meal

Outcomes

Primary Outcome Measures

Postprandial triglycerides
Triglyceride from serum

Secondary Outcome Measures

Postprandial cholesterol
Cholesterol from serum
Postprandial low density lipoprotein
Low density lipoprotein from serum
Postprandial high density lipoprotein
High density lipoprotein from serum
Postprandial glucose
Glucose from serum
Postprandial insulin
Insulin from serum
Fasting Triglyceride
Triglyceride from serum
Fasting cholesterol
Cholesterol from serum
Fasting LDL-cholesterol
LDL from serum
Fasting HDL-cholesterol
HDL from serum
Fasting glucose
Glucose from serum
Fasting Insulin
Insulin from serum
Postprandial fat oxidation
Fat oxidation assessed by expiratory gases
Fat mass
Fat mass assessed by dual energy x-ray absorptiometry
Waist Girth
Waist girth assessed by a measurement tape

Full Information

First Posted
June 27, 2018
Last Updated
June 10, 2020
Sponsor
University of Saskatchewan
Collaborators
Heart and Stroke Foundation of Canada
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1. Study Identification

Unique Protocol Identification Number
NCT03587051
Brief Title
Low Versus High-glycemic Index Post-exercise Diets for Improving Metabolism and Body Composition
Official Title
Endurance Training and Post-exercise Low Glycemic Index Recovery Diet for Improving Postprandial Triglycerides
Study Type
Interventional

2. Study Status

Record Verification Date
June 2020
Overall Recruitment Status
Completed
Study Start Date
July 15, 2018 (Actual)
Primary Completion Date
September 30, 2019 (Actual)
Study Completion Date
December 30, 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Saskatchewan
Collaborators
Heart and Stroke Foundation of Canada

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Postprandial triglycerides are a strong risk factor for heart disease. The purpose is to assess the effects of a low-glycemic versus high-glycemic meal after 90 minute exercise sessions that are done 4 times a week for 6 weeks on postprandial triglyceride level. Secondary measurements include other lipids and body composition.
Detailed Description
The increase in triglycerides after a meal (i.e. postprandial triglycerides) is a strong risk factor for cardiovascular disease. Overweight/obese individuals have a greater triglyceride response to the same meal compared to lean individuals; therefore they are at greater risk. If exercise is performed the evening before a high-fat breakfast, the postprandial levels of triglycerides after the breakfast are reduced; however, if high glycemic index (GI) foods are consumed after the exercise session, the benefits of exercise on next-day postprandial triglycerides is negated. The investigators recently showed (HSFC funded) that consuming low GI foods after exercise is similar to fasting after exercise and superior to consumption of high GI foods for lowering next-day postprandial triglycerides. Low GI food was also superior for increasing fat oxidation, and lowering insulin, and low and very low density lipoproteins and preventing a decrease in high density lipoproteins. The benefits of an acute exercise session followed by low GI food consumption is now clear; however, it is not known whether this practice over weeks of exercise training results in accumulated and sustained benefits. The purpose of this study is to determine the chronic effects of consuming low compared to high GI foods after exercise sessions over six weeks in overweight and obese individuals. Twenty-four overweight and obese males and females will be randomized to consume either high or low GI foods immediately after exercise sessions (four sessions per week, 90 minutes per session, six weeks). At all other times of the day over the six weeks, they will be supplied a moderate GI diet, with calories and macronutrients based on four-day food diaries completed before the study. Two weeks before the intervention, participants will be required to go on the moderate GI diet, as a lead-in. One week into the lead-in, a baseline test will be done to determine postprandial metabolic responses (i.e. triglycerides, low and very low density lipoproteins, high density lipoproteins, insulin, and fat oxidation) after a morning high-fat breakfast. A week later, the same postprandial testing will be carried out the morning after the first exercise and post-exercise consumption of a low or high GI recovery meal. Participants will continue the training and post-exercise food consumption for the next six weeks, with postprandial measures taken again following the final exercise and feeding session. Body composition and aerobic fitness will be determined before and after the six week intervention. The investigators hypothesize that the low GI post-exercise feeding will be superior to the high GI post-exercise feeding for reducing body fat, improving fat oxidation, and reducing postprandial triglycerides, insulin and other harmful lipids. The results of the study will provide clinicians, exercise professionals and dietitians unique and experimentally tested strategies for their clients to lose body fat and improve metabolic profiles, to reduce the risk of heart disease.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hypercholesterolemia

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
25 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Low glycemic index post-exercise diet
Arm Type
Experimental
Arm Description
Lentil-based post-exercise meal
Arm Title
High glycemic index post-exercise diet
Arm Type
Active Comparator
Arm Description
Instant potato, white bread, and egg white post-exercise meal
Intervention Type
Dietary Supplement
Intervention Name(s)
Low glycemic index post-exercise diet
Intervention Description
Feeding of a low-glycemic index, lentil meal after 90 minutes of walking exercise
Intervention Type
Dietary Supplement
Intervention Name(s)
High glycemic index post-exercise diet
Intervention Description
Feeding of a high-glycemic index meal (i.e. instant mashed potatoes, white bread, egg whites) after 90 minutes of walking exercise
Primary Outcome Measure Information:
Title
Postprandial triglycerides
Description
Triglyceride from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Secondary Outcome Measure Information:
Title
Postprandial cholesterol
Description
Cholesterol from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Postprandial low density lipoprotein
Description
Low density lipoprotein from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Postprandial high density lipoprotein
Description
High density lipoprotein from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Postprandial glucose
Description
Glucose from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Postprandial insulin
Description
Insulin from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fasting Triglyceride
Description
Triglyceride from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fasting cholesterol
Description
Cholesterol from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fasting LDL-cholesterol
Description
LDL from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fasting HDL-cholesterol
Description
HDL from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fasting glucose
Description
Glucose from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fasting Insulin
Description
Insulin from serum
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Postprandial fat oxidation
Description
Fat oxidation assessed by expiratory gases
Time Frame
Change from baseline to 1 week and 6 weeks
Title
Fat mass
Description
Fat mass assessed by dual energy x-ray absorptiometry
Time Frame
Change from baseline to 6 weeks
Title
Waist Girth
Description
Waist girth assessed by a measurement tape
Time Frame
Change from baseline to 6 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
44 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Overweight or obese (BMI 25 or greater) Exclusion Criteria: Smokers Diabetic Taking medications that affect carbohydrate or lipid metabolism
Facility Information:
Facility Name
University of Saskatchewan
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 5B2
Country
Canada

12. IPD Sharing Statement

Plan to Share IPD
No

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Low Versus High-glycemic Index Post-exercise Diets for Improving Metabolism and Body Composition

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