Magnetic Brain Stimulation for the Treatment of Adult Depression
Depression
About this trial
This is an interventional treatment trial for Depression focused on measuring Electric Stimulation, Magnetic Stimulation, Prefrontal Cortex, Brain
Eligibility Criteria
Inclusion Criteria: Diagnosis of major depression with a current episode Hamilton Rating Scale for Depression score higher than 20 No response or intolerance to antidepressant medication in the current depressive episode Exclusion Criteria: Current use of antidepressants Diagnosis of psychosis or anxiety disorder Current substance abuse Seizures or history of head trauma
Sites / Locations
- Emory University
- Columbia University
- Brain Stimulation Laboratory, Medical University of South Carolina
- University of Washington
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Placebo Comparator
Experimental
Experimental
Active prefrontal rTMS phase1
Sham rTMS phase 1
rTMS extension
Open label antidepressant regimen
Phase I participants receiving rTMS
Phase I participants receiving sham stimulation
rTMS. Phase II participants, all of whom did not meet remission requirements after phase 1. They all receive active open label rTMS
All patients who met remission who were then transitioned to medications after the TMS trial was completed.