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MagnetisMM-5: Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (MAGNETISMM-5)

Primary Purpose

Multiple Myeloma

Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Elranatamab
Daratumumab
Pomalidomide
Dexamethasone
Sponsored by
Pfizer
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Multiple Myeloma focused on measuring Elranatamab, PF-06863135, B-Cell Maturation Antigen, BCMA, Bispecific antibody, BCMA-CD3 bispecific antibody, Daratumumab, Pomalidomide, Multiple myeloma, Relapsed multiple myeloma, Refractory multiple myeloma, MagnetisMM-5

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Prior diagnosis of multiple myeloma as defined by IMWG criteria (Rajkumar et al, 2014).

  • Measurable disease based on IMWG criteria as defined by at least 1 of the following:

    • Serum M-protein ≥0.5 g/dL.
    • Urinary M-protein excretion ≥200 mg/24 hours.
    • Serum immunoglobulin FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FLC ratio (<0.26 or >1.65).
  • Prior anti-multiple myeloma therapy including treatment with lenalidomide and a proteasome inhibitor.
  • ECOG performance status ≤2.
  • Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1.
  • Not pregnant and willing to use contraception.

Exclusion Criteria:

  • Smoldering multiple myeloma.
  • Plasma cell leukemia.
  • Amyloidosis.
  • POEMS Syndrome.
  • Stem cell transplant within 12 weeks prior to enrolment, or active graft versus host disease.
  • Active HBV, HCV, SARS-CoV2, HIV, or any active, uncontrolled bacterial, fungal, or viral infection.
  • Any other active malignancy within 3 years prior to enrolment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ.
  • Previous treatment with a BCMA-directed therapy.
  • Anti-CD38-directed therapy within 6 months preceding the first dose of treatment in this study.
  • Live attenuated vaccine within 4 weeks of the first dose of study intervention.
  • Administration with an investigational product (e.g. drug or vaccine) concurrent with study intervention or within 30 days preceding the first dose of study intervention used in this study.

Sites / Locations

  • Clovis Community Medical CenterRecruiting
  • Community Cancer InstituteRecruiting
  • University of California San FranciscoRecruiting
  • Community Regional Medical CenterRecruiting
  • Tulane Cancer CenterRecruiting
  • Tulane Medical CenterRecruiting
  • Alexander Fleming S.A (Instituto Medico Especializado Alexander Fleming)Recruiting
  • FUNDALEU - Fundacion para combatir la LeucemiaRecruiting
  • FUNDALEU -Fundación para combatir la leucemiaRecruiting
  • FUNDALEURecruiting
  • Hospital Universitario AustralRecruiting
  • Hospital Italiano de la PlataRecruiting
  • Sanatorio de La MujerRecruiting
  • Pindara Private HospitalRecruiting
  • QScan Radiology ClinicsRecruiting
  • Gallipoli Medical Research FoundationRecruiting
  • Greenslopes Private HospitalRecruiting
  • Princess Alexandra HospitalRecruiting
  • Epworth FreemasonsRecruiting
  • St Vincent's Hospital (Melbourne)Recruiting
  • Barwon HealthRecruiting
  • The Alfred HospitalRecruiting
  • Epworth HealthcareRecruiting
  • Slade PharmacyRecruiting
  • Universitätsklinikum KremsRecruiting
  • Medizinische Universität WienRecruiting
  • Universitaetsklinikum Allgemeines Krankenhaus WienRecruiting
  • Klinik OttakringRecruiting
  • Universitätsklinik für Innere Medizin V InnsbruckRecruiting
  • Uniklinikum SalzburgRecruiting
  • Medizinische Universität WienRecruiting
  • Grand Hôpital de Charleroi
  • CHU UCL Namur (site Godinne)Recruiting
  • Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial SalvadorRecruiting
  • Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E PesquisaRecruiting
  • Centro de Pesquisa Clínica - Área AdministrativaRecruiting
  • Hospital Mae de DeusRecruiting
  • Hospital Santa Cruz / Centro de PesquisaRecruiting
  • BP - A Beneficencia Portuguesa de São PauloRecruiting
  • Hospital Américas Medical CityRecruiting
  • Instituto de Educação, Pesquisa e Gestão e SaúdeRecruiting
  • Instituto de Educação, Pesquisa e Gestão em SaúdeRecruiting
  • ESHO Empresa de Serviços Hospitalares S.A/ Hospital Samaritano de HigienópolisRecruiting
  • HU UNIFESP / SPDM - Hospital São PauloRecruiting
  • Universidade Federal de Sao PauloRecruiting
  • Hospital Japonês Santa CruzRecruiting
  • Clínica Médica São Germano S/S LtdaRecruiting
  • Instituto D'Or de Pesquisa e Ensino (IDOR)Recruiting
  • Instituto D'Or de Pesquisa e Ensino (IDOR)Recruiting
  • Sociedade Beneficente Israelita Brasileira Hospital Albert EinsteinRecruiting
  • Tom Baker Cancer CenterRecruiting
  • Cross Cancer InstituteRecruiting
  • QEII Health Sciences Centre - Victoria General SiteRecruiting
  • Queen Elizabeth II Health Science CentreRecruiting
  • Hamilton Health Sciences-Juravinski Cancer CentreRecruiting
  • Princess Margaret Cancer CentreRecruiting
  • Jewish General HospitalRecruiting
  • CIUSSS de l'Est-de-l'Île-de-MontréalRecruiting
  • Saskatoon Cancer CenterRecruiting
  • Peking University Third HospitalRecruiting
  • Beijing Peking Union Medical College HospitalRecruiting
  • Fujian Medical University Union HospitalRecruiting
  • Guangdong Provincial People's HospitalRecruiting
  • Nanfang Hospital of Southern Medical UniversityRecruiting
  • Sun Yat-sen University Cancer CenterRecruiting
  • Shenzhen Second People's HospitalRecruiting
  • The Second Hospital of Hebei Medical UniversityRecruiting
  • Harbin Medical University Cancer HospitalRecruiting
  • Henan Cancer HospitalRecruiting
  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRecruiting
  • Nanjing Drum Tower Hospital ， The Affiliated Hospital of Nanjing University Medical SchoolRecruiting
  • The Affiliated Hospital of Xuzhou Medical UniversityRecruiting
  • The First Affiliated Hospital of Nanchang UniversityRecruiting
  • Jilin Province Cancer HospitalRecruiting
  • The first hospital of Jilin UniversityRecruiting
  • Jinan Central Hospital
  • Shandong Provincial HospitalRecruiting
  • Jinan Central HospitalRecruiting
  • Institute of hematology&blood disease hospitalRecruiting
  • Tianjin Medical University General HospitalRecruiting
  • The First Affiliated Hospital, Zhejiang UniversityRecruiting
  • The First Affiliated Hospital of Wenzhou Medical UniversityRecruiting
  • Beijing Boren HospitalRecruiting
  • Chongqing University Cancer HospitalRecruiting
  • Jinan Central HospitalRecruiting
  • Fakultní nemocnice Brno BohuniceRecruiting
  • Fakultni Nemocnice PlzenRecruiting
  • Fakultni poliklinikaRecruiting
  • Fakultni nemocnice Hradec KraloveRecruiting
  • Fakultni nemocnice OlomoucRecruiting
  • Fakultni nemocnice OstravaRecruiting
  • Vseobecna fakultni nemocnice v PrazeRecruiting
  • Tampereen yliopistollinen sairaalaRecruiting
  • Oulun yliopistollinen sairaalaRecruiting
  • Kuopion Yliopistollinen SairaalaRecruiting
  • Turku University HospitalRecruiting
  • Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)Recruiting
  • Tampereen yliopistollinen sairaalaRecruiting
  • CHU Bordeaux Haut-Leveque
  • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
  • Hopital Claude Huriez - CHU de LilleRecruiting
  • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-DieuRecruiting
  • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-DieuRecruiting
  • Hôpital Saint AntoineRecruiting
  • Hopital NeckerRecruiting
  • Centre Hospitalier Lyon Sud - Service d'Hematologie CliniqueRecruiting
  • CHU de Poitiers, Hôpital de la Milétrie, Pôle Régional de CancérologieRecruiting
  • Universitaetsklinikum Ulm
  • Universitätsklinikum WürzburgRecruiting
  • Universitaetsklinikum KoelnRecruiting
  • Uniklinik RWTH AachenRecruiting
  • Charité Universitätsmedizin BerlinRecruiting
  • Staedtisches Klinikum Braunschweig gGmbHRecruiting
  • Klinikum Chemnitz gGMbHRecruiting
  • St. Barbara-Klinik Hamm-Heessen
  • Universitätsklinikum rechts der Isar, Technische Universität München (TUM)Recruiting
  • Klinikum rechts der Isar der Technischen Universität MünchenRecruiting
  • Evangelismos General Hospital of AthensRecruiting
  • Evangelismos HospitalRecruiting
  • Alexandra General Hospital of AthensRecruiting
  • Theageneio Cancer Hospital of ThessalonikiRecruiting
  • University General Hospital of IoanninaRecruiting
  • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"Recruiting
  • Ospedale San MartinoRecruiting
  • Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoRecruiting
  • Fondazione IRCCS San Gerardo dei Tintori
  • ASST Santi Paolo e Carlo Ospedale San Carlo Borromeo SSD di Onco-Ematologia (Edificio C-piano terra)Recruiting
  • Policlinico "G. Rodolico"Recruiting
  • Azienda Ospedaliero Universitaria SeneseRecruiting
  • IRCCS - AOU di BolognaRecruiting
  • AOU Policlinico Umberto IRecruiting
  • Fondazione Policlinico Universitario Agostino GemelliRecruiting
  • Nagoya City University HospitalRecruiting
  • Toyohashi Municipal HospitalRecruiting
  • University of Fukui HospitalRecruiting
  • National Hospital Organization Shibukawa Medical CenterRecruiting
  • Iwate Medical University HospitalRecruiting
  • Tohoku University HospitalRecruiting
  • Hamamatsu University HospitalRecruiting
  • Shizuoka Cancer CenterRecruiting
  • Japanese Red Cross Medical CenterRecruiting
  • Akita University HospitalRecruiting
  • National Hospital Organization Kyushu Cancer CenterRecruiting
  • Kyushu University HospitalRecruiting
  • Kagoshima University HospitalRecruiting
  • National Hospital Organization Kumamoto Medical CenterRecruiting
  • Nagasaki University HospitalRecruiting
  • National Hospital Organization Okayama Medical CenterRecruiting
  • Osaka Metropolitan University HospitalRecruiting
  • Tokushima University HospitalRecruiting
  • Yamagata University HospitalRecruiting
  • Seoul National University Bundang HospitalRecruiting
  • Chonnam National University Hwasun HospitalRecruiting
  • Pusan National University HospitalRecruiting
  • Seoul National University HospitalRecruiting
  • Samsung Medical CenterRecruiting
  • The Catholic Univ. of Korea Seoul St. Mary's HospitalRecruiting
  • Kyungpook National University HospitalRecruiting
  • Kyungpook National University HospitalRecruiting
  • Gachon University Gil Medical CenterRecruiting
  • Asan Medical CenterRecruiting
  • Hematológica Alta Especialidad SC, consultorio 830Recruiting
  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
  • Centro de Investigacion Clinica de OaxacaRecruiting
  • Instituto Veracruzano en Investigación Clínica S.C.Recruiting
  • Erasmus Universitair Medisch CentrumRecruiting
  • Maastricht University Medical CenterRecruiting
  • North Shore HospitalRecruiting
  • North Shore HospitalRecruiting
  • Aotearoa Clinical TrialsRecruiting
  • Middlemore Clinical TrialsRecruiting
  • Waikato HospitalRecruiting
  • Palmerston North HospitalRecruiting
  • Capital, Coast and Hutt Valley District - Wellington Regional HospitalRecruiting
  • Haukeland UniversitetssjukehusRecruiting
  • Stavanger UniversitetssykehusRecruiting
  • Oslo Universitetssykehus UllevålRecruiting
  • St Olavs HospitalRecruiting
  • Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy Klinika HematologiiRecruiting
  • Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyRecruiting
  • Uniwersyteckie Centrum KliniczneRecruiting
  • Pratia Onkologia KatowiceRecruiting
  • Szpital Kliniczny im. Heliodora Święcickiego UM w PoznaniuRecruiting
  • Centrum Medyczne Pratia PoznanRecruiting
  • Uniwersyteckie Centrum Kliniczne WUM Centralny Szpital KlinicznyRecruiting
  • Klinika Hematologii, Nowotworow Krwi i Transplantacji SzpikuRecruiting
  • Complejo Hospitalario Universitario de SantiagoRecruiting
  • Institut Català d'Oncologia - L'HospitaletRecruiting
  • Hospital Universitario Mutua TerrassaRecruiting
  • Hospital Universitario Marqués de ValdecillaRecruiting
  • Clinica Universidad de NavarraRecruiting
  • Clinica Universidad de NavarraRecruiting
  • Hospital Universitario de ToledoRecruiting
  • Hospital Universitari Vall d'HebronRecruiting
  • Hospital Clinic BarcelonaRecruiting
  • Hospital Universitario Reina SofíaRecruiting
  • Hospital Universitari De Girona Doctor Josep TruetaRecruiting
  • Hospital Universitario La PrincesaRecruiting
  • Hospital Universitario Madrid SanchinarroRecruiting
  • Hospital Universitario de SalamancaRecruiting
  • Hospital Universitario Virgen Del RocioRecruiting
  • Hospital Universitario y Politecnico La FeRecruiting
  • Helsingborgs LasarettRecruiting
  • Skånes Universitetssjukhus LundRecruiting
  • Södra Älvsborg SjukhusRecruiting
  • Falu LasarettRecruiting
  • Sahlgrenska UniversitetssjukhusetRecruiting
  • Sunderby SjukhusRecruiting
  • Universitetssjukhuset ÖrebroRecruiting
  • Universitetssjukhuset i LinköpingRecruiting
  • Chang Gung Memorial Hospital at KaohsiungRecruiting
  • China Medical University HospitalRecruiting
  • National Cheng Kung University HospitalRecruiting
  • National Taiwan University HospitalRecruiting
  • Taipei Veterans General HospitalRecruiting
  • Sisli Florence Nightingale HastanesiRecruiting
  • Istanbul Universitesi Istanbul Tıp Fakultesi HastanesiRecruiting
  • Medipol Mega Universite HastanesiRecruiting
  • Acibadem Universitesi Atakent HastanesiRecruiting
  • Ege Universitesi HastanesiRecruiting
  • Dokuz Eylul Universitesi HastanesiRecruiting
  • Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma MerkeziRecruiting
  • Ankara Universitesi Tip Fakultesi HastanesiRecruiting
  • Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma HastanesiRecruiting
  • Akdeniz Universitesi HastanesiRecruiting
  • Aydın Adnan Menderes Universitesi HastanesiRecruiting
  • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama HastanesiRecruiting
  • Erciyes Universitesi Tıp Fakultesi HastaneleriRecruiting
  • Özel Anadolu Sağlık MerkeziRecruiting
  • Inonu Universitesi Turgut Ozal Tıp MerkeziRecruiting
  • Royal Bournemouth HospitalRecruiting
  • Churchill HospitalRecruiting
  • Churchill Hospital, Oxford University Hospitals NHS Foundation TrustRecruiting
  • University Hospital of WalesRecruiting
  • Bristol Haematology and Oncology CentreRecruiting
  • Kent and Canterbury HospitalRecruiting
  • The Christie NHS Foundation TrustRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

Experimental

Experimental

Experimental

Active Comparator

Experimental

Experimental

Arm Label

Part 1 Safety Lead-In Dose Escalation: Elranatamab + Daratumumab

Part 2 Randomized Arm A: Elranatamab

Part 2 Randomized Arm B: Elranatamab + Daratumumab

Part 2 Randomized Arm C: Daratumumab + Pomalidomide + Dexamethasone

Part 3 Randomized Arm D: Alternative Elranatamab dosing + Daratumumab

Part 3 Randomized Arm E: Elranatamab + Daratumumab

Arm Description

Outcomes

Primary Outcome Measures

Part 1 Safety Lead-In: Incidence of dose limiting toxicities
Part 2 Randomized: Progression free survival per International Myeloma Working Group criteria
Part 3: Frequency of treatment-emergent adverse events

Secondary Outcome Measures

Part 1 Safety Lead-In: Progression free survival per International Myeloma Working Group criteria
Overall survival
Objective response rate per International Myeloma Working Group criteria
Duration of response per International Myeloma Working Group criteria
Time to response per International Myeloma Working Group criteria
Complete response rate per International Myeloma Working Group criteria
Duration of complete response per International Myeloma Working Group criteria
Minimal residual disease negativity rate per International Myeloma Working Group criteria
Sustained minimal residual disease negativity rate per International Myeloma Working Group criteria
Progression free survival on next-line treatment per International Myeloma Working Group criteria
Frequency of treatment-emergent adverse events
Frequency of abnormal laboratory results
Rate of Grade ≥2 cytokine release syndrome
Elranatamab pharmacokinetics by pre- and post-dose concentrations
Elranatamab immunogenicity by anti-drug antibodies against elranatamab
Daratumumab pharmacokinetics by pre-dose concentrations
Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30
Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Myeloma 20

Full Information

First Posted
August 11, 2021
Last Updated
August 22, 2023
Sponsor
Pfizer
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1. Study Identification

Unique Protocol Identification Number
NCT05020236
Brief Title
MagnetisMM-5: Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma
Acronym
MAGNETISMM-5
Official Title
AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) MONOTHERAPY AND ELRANATAMAB + DARATUMUMAB VERSUS DARATUMUMAB + POMALIDOMIDE + DEXAMETHASONE IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST 1 PRIOR LINE OF THERAPY INCLUDING LENALIDOMIDE AND A PROTEASOME INHIBITOR
Study Type
Interventional

2. Study Status

Record Verification Date
August 2023
Overall Recruitment Status
Recruiting
Study Start Date
October 4, 2021 (Actual)
Primary Completion Date
December 27, 2024 (Anticipated)
Study Completion Date
September 28, 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Pfizer

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to evaluate whether the BCMA-CD3 bispecific antibody elranatamab, alone and/or in combination with the anti-CD38 monoclonal antibody, daratumumab, can provide more benefit to people with multiple myeloma compared to a combination therapy including daratumumab, pomalidomide, and dexamethasone. People with multiple myeloma who have received previous treatment including lenalidomide and a proteasome inhibitor will be enrolled in the study. Part 1 of the study will assess the safety and activity of different doses of elranatamab in combination with daratumumab. People participating in Part 2 of the study will be randomly assigned to receive either elranatamab alone, elranatamab plus daratumumab, or daratumumab, pomalidomide, and dexamethasone. Part 2 will compare the safety and activity of (1) elranatamab alone compared to daratumumab, pomalidomide, and dexamethasone, and (2) elranatamab plus daratumumab compared to daratumumab, pomalidomide, and dexamethasone. Part 3 of the study will evaluate an alternative dosing schedule of elranatamab in combination with daratumumab. Participants in all parts of the study will receive study treatment until their disease progresses, they experience unacceptable side effects, or they choose to no longer participate in the study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Multiple Myeloma
Keywords
Elranatamab, PF-06863135, B-Cell Maturation Antigen, BCMA, Bispecific antibody, BCMA-CD3 bispecific antibody, Daratumumab, Pomalidomide, Multiple myeloma, Relapsed multiple myeloma, Refractory multiple myeloma, MagnetisMM-5

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Factorial Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
854 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Part 1 Safety Lead-In Dose Escalation: Elranatamab + Daratumumab
Arm Type
Experimental
Arm Title
Part 2 Randomized Arm A: Elranatamab
Arm Type
Experimental
Arm Title
Part 2 Randomized Arm B: Elranatamab + Daratumumab
Arm Type
Experimental
Arm Title
Part 2 Randomized Arm C: Daratumumab + Pomalidomide + Dexamethasone
Arm Type
Active Comparator
Arm Title
Part 3 Randomized Arm D: Alternative Elranatamab dosing + Daratumumab
Arm Type
Experimental
Arm Title
Part 3 Randomized Arm E: Elranatamab + Daratumumab
Arm Type
Experimental
Intervention Type
Drug
Intervention Name(s)
Elranatamab
Other Intervention Name(s)
PF-06863135
Intervention Description
subcutaneous
Intervention Type
Drug
Intervention Name(s)
Daratumumab
Other Intervention Name(s)
Darzalex Faspro; Darzalex solution for injection
Intervention Description
Daratumumab / hyaluronidase, subcutaneous
Intervention Type
Drug
Intervention Name(s)
Pomalidomide
Other Intervention Name(s)
Pomalyst, Imnovid
Intervention Description
oral
Intervention Type
Drug
Intervention Name(s)
Dexamethasone
Intervention Description
oral
Primary Outcome Measure Information:
Title
Part 1 Safety Lead-In: Incidence of dose limiting toxicities
Time Frame
First 42 days after first elranatamab dose
Title
Part 2 Randomized: Progression free survival per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of progressive disease, discontinuation from the study, death, or censoring, whichever occurs first, assessed up to 51 months
Title
Part 3: Frequency of treatment-emergent adverse events
Time Frame
From date of first dose of study intervention through minimum of 90 days after last study intervention administration. Reporting of non-serious AEs ends at start of new anti-cancer therapy.
Secondary Outcome Measure Information:
Title
Part 1 Safety Lead-In: Progression free survival per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of progressive disease, discontinuation from study, death, or censoring, whichever occurs first, assessed up to 51 months
Title
Overall survival
Time Frame
From date of randomization to date of discontinuation from study, death, or censoring, whichever occurs first, assessed up to 51 months
Title
Objective response rate per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of progressive disease, discontinuation from study, death, or start of new anticancer therapy, whichever occurs first, assessed up to 51 months
Title
Duration of response per International Myeloma Working Group criteria
Time Frame
From date of confirmed objective response to date of progressive disease, discontinuation from study, death, or censoring, whichever occurs first, assessed up to 51 months
Title
Time to response per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of confirmed objective response, assessed up to 51 months
Title
Complete response rate per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of progressive disease, discontinuation from study, death, or start of new anticancer therapy, whichever occurs first, assessed up to 51 months
Title
Duration of complete response per International Myeloma Working Group criteria
Time Frame
From date of confirmed complete response to date of progressive disease, discontinuation from study, death, or censoring, whichever occurs first, assessed up to 51 months
Title
Minimal residual disease negativity rate per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of progressive disease, discontinuation from study, death, or start of new anticancer therapy, whichever occurs first, assessed up to 51 months
Title
Sustained minimal residual disease negativity rate per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of progressive disease, discontinuation from study, death, or start of new anticancer therapy, whichever occurs first, assessed up to 51 months
Title
Progression free survival on next-line treatment per International Myeloma Working Group criteria
Time Frame
From date of randomization to date of second objective disease progression, discontinuation from the study, death, or censoring, whichever occurs first, assessed up to 51 months
Title
Frequency of treatment-emergent adverse events
Time Frame
From date of first dose of study intervention through minimum of 90 days after last study intervention administration. Reporting of non-serious AEs ends at start of new anti-cancer therapy.
Title
Frequency of abnormal laboratory results
Time Frame
From date of first dose of study intervention through minimum of 90 days after last study intervention administration. Reporting of non-serious AEs ends at start of new anti-cancer therapy.
Title
Rate of Grade ≥2 cytokine release syndrome
Time Frame
First 28 days after first elranatamab dose
Title
Elranatamab pharmacokinetics by pre- and post-dose concentrations
Time Frame
From date of first dose through up to 14 days after date of last dose of elranatamab
Title
Elranatamab immunogenicity by anti-drug antibodies against elranatamab
Time Frame
From date of first dose through up to 14 days after date of last dose of elranatamab
Title
Daratumumab pharmacokinetics by pre-dose concentrations
Time Frame
From date of first dose through up to 14 days after date of last dose of daratumumab
Title
Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30
Time Frame
From date of informed consent through up to 35 days after date of last dose of study intervention
Title
Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Myeloma 20
Time Frame
From date of informed consent through up to 35 days after date of last dose of study intervention

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Prior diagnosis of multiple myeloma as defined by IMWG criteria (Rajkumar et al, 2014). Measurable disease based on IMWG criteria as defined by at least 1 of the following: Serum M-protein ≥0.5 g/dL. Urinary M-protein excretion ≥200 mg/24 hours. Serum immunoglobulin FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FLC ratio (<0.26 or >1.65). Prior anti-multiple myeloma therapy including treatment with lenalidomide and a proteasome inhibitor. ECOG performance status ≤2. Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1. Not pregnant and willing to use contraception. Exclusion Criteria: Smoldering multiple myeloma. Plasma cell leukemia. Amyloidosis. POEMS Syndrome. Stem cell transplant within 12 weeks prior to enrolment, or active graft versus host disease. Active HBV, HCV, SARS-CoV2, HIV, or any active, uncontrolled bacterial, fungal, or viral infection. Any other active malignancy within 3 years prior to enrolment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ. Previous treatment with a BCMA-directed therapy. Anti-CD38-directed therapy within 6 months preceding the first dose of treatment in this study. Live attenuated vaccine within 4 weeks of the first dose of study intervention. Administration with an investigational product (e.g. drug or vaccine) concurrent with study intervention or within 30 days preceding the first dose of study intervention used in this study.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Pfizer CT.gov Call Center
Phone
1-800-718-1021
Email
ClinicalTrials.gov_Inquiries@pfizer.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Pfizer CT.gov Call Center
Organizational Affiliation
Pfizer
Official's Role
Study Director
Facility Information:
Facility Name
Clovis Community Medical Center
City
Clovis
State/Province
California
ZIP/Postal Code
93611
Country
United States
Individual Site Status
Recruiting
Facility Name
Community Cancer Institute
City
Clovis
State/Province
California
ZIP/Postal Code
93611
Country
United States
Individual Site Status
Recruiting
Facility Name
University of California San Francisco
City
Fresno
State/Province
California
ZIP/Postal Code
93701
Country
United States
Individual Site Status
Recruiting
Facility Name
Community Regional Medical Center
City
Fresno
State/Province
California
ZIP/Postal Code
93721
Country
United States
Individual Site Status
Recruiting
Facility Name
Tulane Cancer Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Individual Site Status
Recruiting
Facility Name
Tulane Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Individual Site Status
Recruiting
Facility Name
Alexander Fleming S.A (Instituto Medico Especializado Alexander Fleming)
City
Ciudad Autonoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
1426
Country
Argentina
Individual Site Status
Recruiting
Facility Name
FUNDALEU - Fundacion para combatir la Leucemia
City
Ciudad Autonoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1114AAN
Country
Argentina
Individual Site Status
Recruiting
Facility Name
FUNDALEU -Fundación para combatir la leucemia
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1114AAP
Country
Argentina
Individual Site Status
Recruiting
Facility Name
FUNDALEU
City
Ciudad Autónoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1114AAP
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Austral
City
Derqui, Pilar
State/Province
Buenos Aires
ZIP/Postal Code
B1629AHJ
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Hospital Italiano de la Plata
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1900XI
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Sanatorio de La Mujer
City
Rosario
State/Province
Santa FE
ZIP/Postal Code
S2000ORE
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Pindara Private Hospital
City
Benowa
State/Province
Queensland
ZIP/Postal Code
4217
Country
Australia
Individual Site Status
Recruiting
Facility Name
QScan Radiology Clinics
City
Clayfield
State/Province
Queensland
ZIP/Postal Code
4011
Country
Australia
Individual Site Status
Recruiting
Facility Name
Gallipoli Medical Research Foundation
City
Greenslopes
State/Province
Queensland
ZIP/Postal Code
4120
Country
Australia
Individual Site Status
Recruiting
Facility Name
Greenslopes Private Hospital
City
Greenslopes
State/Province
Queensland
ZIP/Postal Code
4120
Country
Australia
Individual Site Status
Recruiting
Facility Name
Princess Alexandra Hospital
City
Woolloongabba
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Individual Site Status
Recruiting
Facility Name
Epworth Freemasons
City
East Melbourne
State/Province
Victoria
ZIP/Postal Code
3002
Country
Australia
Individual Site Status
Recruiting
Facility Name
St Vincent's Hospital (Melbourne)
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Individual Site Status
Recruiting
Facility Name
Barwon Health
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
Individual Site Status
Recruiting
Facility Name
The Alfred Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Individual Site Status
Recruiting
Facility Name
Epworth Healthcare
City
Richmond
State/Province
Victoria
ZIP/Postal Code
3121
Country
Australia
Individual Site Status
Recruiting
Facility Name
Slade Pharmacy
City
Richmond
State/Province
Victoria
ZIP/Postal Code
3121
Country
Australia
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Krems
City
Krems
State/Province
Niederösterreich
ZIP/Postal Code
3500
Country
Austria
Individual Site Status
Recruiting
Facility Name
Medizinische Universität Wien
City
Vienna
State/Province
Wien
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Recruiting
Facility Name
Universitaetsklinikum Allgemeines Krankenhaus Wien
City
Vienna
State/Province
Wien
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Recruiting
Facility Name
Klinik Ottakring
City
Vienna
State/Province
Wien
ZIP/Postal Code
1160
Country
Austria
Individual Site Status
Recruiting
Facility Name
Universitätsklinik für Innere Medizin V Innsbruck
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Individual Site Status
Recruiting
Facility Name
Uniklinikum Salzburg
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Individual Site Status
Recruiting
Facility Name
Medizinische Universität Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Recruiting
Facility Name
Grand Hôpital de Charleroi
City
Charleroi
State/Province
Hainaut
ZIP/Postal Code
6000
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Name
CHU UCL Namur (site Godinne)
City
Yvoir
State/Province
Namur
ZIP/Postal Code
5530
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
City
Salvador,
State/Province
Bahia
ZIP/Postal Code
41253-190
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
City
Porto Alegre
State/Province
RIO Grande DO SUL
ZIP/Postal Code
90110-270
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Centro de Pesquisa Clínica - Área Administrativa
City
Porto Alegre
State/Province
RIO Grande DO SUL
ZIP/Postal Code
90850-170
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Mae de Deus
City
Porto Alegre
State/Province
RIO Grande DO SUL
ZIP/Postal Code
90880-480
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Santa Cruz / Centro de Pesquisa
City
São Paulo
State/Province
SP
ZIP/Postal Code
04122-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
BP - A Beneficencia Portuguesa de São Paulo
City
Sao Paulo
State/Province
SÃO Paulo
ZIP/Postal Code
01321-001
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Américas Medical City
City
Rio de Janeiro
ZIP/Postal Code
22775001
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto de Educação, Pesquisa e Gestão e Saúde
City
Rio de janeiro
ZIP/Postal Code
22793-080
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto de Educação, Pesquisa e Gestão em Saúde
City
Rio de Janeiro
ZIP/Postal Code
22793-080
Country
Brazil
Individual Site Status
Recruiting
Facility Name
ESHO Empresa de Serviços Hospitalares S.A/ Hospital Samaritano de Higienópolis
City
São Paulo
ZIP/Postal Code
01232-010
Country
Brazil
Individual Site Status
Recruiting
Facility Name
HU UNIFESP / SPDM - Hospital São Paulo
City
São Paulo
ZIP/Postal Code
04024-002
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Universidade Federal de Sao Paulo
City
São Paulo
ZIP/Postal Code
04024-002
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Japonês Santa Cruz
City
São Paulo
ZIP/Postal Code
04122-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Clínica Médica São Germano S/S Ltda
City
São Paulo
ZIP/Postal Code
04537-080
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto D'Or de Pesquisa e Ensino (IDOR)
City
São Paulo
ZIP/Postal Code
04543-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto D'Or de Pesquisa e Ensino (IDOR)
City
São Paulo
ZIP/Postal Code
04544-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
City
São Paulo
ZIP/Postal Code
05652-900
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Tom Baker Cancer Center
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Individual Site Status
Recruiting
Facility Name
Cross Cancer Institute
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Individual Site Status
Recruiting
Facility Name
QEII Health Sciences Centre - Victoria General Site
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Individual Site Status
Recruiting
Facility Name
Queen Elizabeth II Health Science Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Individual Site Status
Recruiting
Facility Name
Hamilton Health Sciences-Juravinski Cancer Centre
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8V5C2
Country
Canada
Individual Site Status
Recruiting
Facility Name
Princess Margaret Cancer Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2M9
Country
Canada
Individual Site Status
Recruiting
Facility Name
Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Individual Site Status
Recruiting
Facility Name
CIUSSS de l'Est-de-l'Île-de-Montréal
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H1T2M4
Country
Canada
Individual Site Status
Recruiting
Facility Name
Saskatoon Cancer Center
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N4H4
Country
Canada
Individual Site Status
Recruiting
Facility Name
Peking University Third Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100191
Country
China
Individual Site Status
Recruiting
Facility Name
Beijing Peking Union Medical College Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100730
Country
China
Individual Site Status
Recruiting
Facility Name
Fujian Medical University Union Hospital
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350001
Country
China
Individual Site Status
Recruiting
Facility Name
Guangdong Provincial People's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Individual Site Status
Recruiting
Facility Name
Nanfang Hospital of Southern Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510515
Country
China
Individual Site Status
Recruiting
Facility Name
Sun Yat-sen University Cancer Center
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510555
Country
China
Individual Site Status
Recruiting
Facility Name
Shenzhen Second People's Hospital
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518035
Country
China
Individual Site Status
Recruiting
Facility Name
The Second Hospital of Hebei Medical University
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050000
Country
China
Individual Site Status
Recruiting
Facility Name
Harbin Medical University Cancer Hospital
City
Harbin
State/Province
Heilongjiang
ZIP/Postal Code
150081
Country
China
Individual Site Status
Recruiting
Facility Name
Henan Cancer Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450008
Country
China
Individual Site Status
Recruiting
Facility Name
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430030
Country
China
Individual Site Status
Recruiting
Facility Name
Nanjing Drum Tower Hospital ， The Affiliated Hospital of Nanjing University Medical School
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210008
Country
China
Individual Site Status
Recruiting
Facility Name
The Affiliated Hospital of Xuzhou Medical University
City
Xuzhou
State/Province
Jiangsu
ZIP/Postal Code
221006
Country
China
Individual Site Status
Recruiting
Facility Name
The First Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Individual Site Status
Recruiting
Facility Name
Jilin Province Cancer Hospital
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130000
Country
China
Individual Site Status
Recruiting
Facility Name
The first hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Individual Site Status
Recruiting
Facility Name
Jinan Central Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250013
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Shandong Provincial Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250021
Country
China
Individual Site Status
Recruiting
Facility Name
Jinan Central Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250100
Country
China
Individual Site Status
Recruiting
Facility Name
Institute of hematology&blood disease hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300020
Country
China
Individual Site Status
Recruiting
Facility Name
Tianjin Medical University General Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300052
Country
China
Individual Site Status
Recruiting
Facility Name
The First Affiliated Hospital, Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310003
Country
China
Individual Site Status
Recruiting
Facility Name
The First Affiliated Hospital of Wenzhou Medical University
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China
Individual Site Status
Recruiting
Facility Name
Beijing Boren Hospital
City
Beijing
ZIP/Postal Code
100070
Country
China
Individual Site Status
Recruiting
Facility Name
Chongqing University Cancer Hospital
City
Chongqing
ZIP/Postal Code
400030
Country
China
Individual Site Status
Recruiting
Facility Name
Jinan Central Hospital
City
Jinan
ZIP/Postal Code
250100
Country
China
Individual Site Status
Recruiting
Facility Name
Fakultní nemocnice Brno Bohunice
City
Brno
State/Province
Brno-m?sto
ZIP/Postal Code
625 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni Nemocnice Plzen
City
Plzen - Lochotin
State/Province
Plzeňský KRAJ
ZIP/Postal Code
304 60
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni poliklinika
City
Praha
State/Province
Praha 2
ZIP/Postal Code
120 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Hradec Kralove
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Olomouc
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Ostrava
City
Ostrava-Poruba
ZIP/Postal Code
708 52
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Vseobecna fakultni nemocnice v Praze
City
Praha 2
ZIP/Postal Code
12808
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Tampereen yliopistollinen sairaala
City
Tampere
State/Province
Pirkanmaa
ZIP/Postal Code
33520
Country
Finland
Individual Site Status
Recruiting
Facility Name
Oulun yliopistollinen sairaala
City
Oulu
State/Province
Pohjois-pohjanmaa
ZIP/Postal Code
90220
Country
Finland
Individual Site Status
Recruiting
Facility Name
Kuopion Yliopistollinen Sairaala
City
Kuopio
State/Province
Pohjois-savo
ZIP/Postal Code
70210
Country
Finland
Individual Site Status
Recruiting
Facility Name
Turku University Hospital
City
Turku
State/Province
Varsinais-suomi
ZIP/Postal Code
20520
Country
Finland
Individual Site Status
Recruiting
Facility Name
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
City
Helsinki
ZIP/Postal Code
00029
Country
Finland
Individual Site Status
Recruiting
Facility Name
Tampereen yliopistollinen sairaala
City
Tampere
ZIP/Postal Code
33520
Country
Finland
Individual Site Status
Recruiting
Facility Name
CHU Bordeaux Haut-Leveque
City
Pessac
State/Province
Aquitaine
ZIP/Postal Code
33600
Country
France
Individual Site Status
Not yet recruiting
Facility Name
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
City
Limoges
State/Province
Limousin
ZIP/Postal Code
87042
Country
France
Individual Site Status
Not yet recruiting
Facility Name
Hopital Claude Huriez - CHU de Lille
City
Lille
State/Province
Nord
ZIP/Postal Code
59000
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
City
Nantes Cedex 1
ZIP/Postal Code
44093
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
City
Nantes
ZIP/Postal Code
44093
Country
France
Individual Site Status
Recruiting
Facility Name
Hôpital Saint Antoine
City
Paris Cedex 12
ZIP/Postal Code
75571
Country
France
Individual Site Status
Recruiting
Facility Name
Hopital Necker
City
Paris
ZIP/Postal Code
75015
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Lyon Sud - Service d'Hematologie Clinique
City
Pierre Benite Cedex
ZIP/Postal Code
69495
Country
France
Individual Site Status
Recruiting
Facility Name
CHU de Poitiers, Hôpital de la Milétrie, Pôle Régional de Cancérologie
City
Poitiers Cedex
ZIP/Postal Code
86021
Country
France
Individual Site Status
Recruiting
Facility Name
Universitaetsklinikum Ulm
City
Ulm
State/Province
Baden-württemberg
ZIP/Postal Code
89081
Country
Germany
Individual Site Status
Not yet recruiting
Facility Name
Universitätsklinikum Würzburg
City
Würzburg
State/Province
Bayern
ZIP/Postal Code
97080
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitaetsklinikum Koeln
City
Köln
State/Province
Nordrhein-westfalen
ZIP/Postal Code
50937
Country
Germany
Individual Site Status
Recruiting
Facility Name
Uniklinik RWTH Aachen
City
Aachen
ZIP/Postal Code
52074
Country
Germany
Individual Site Status
Recruiting
Facility Name
Charité Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
12200
Country
Germany
Individual Site Status
Recruiting
Facility Name
Staedtisches Klinikum Braunschweig gGmbH
City
Braunschweig
ZIP/Postal Code
38114
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinikum Chemnitz gGMbH
City
Chemnitz
ZIP/Postal Code
09116
Country
Germany
Individual Site Status
Recruiting
Facility Name
St. Barbara-Klinik Hamm-Heessen
City
Hamm
ZIP/Postal Code
59073
Country
Germany
Individual Site Status
Not yet recruiting
Facility Name
Universitätsklinikum rechts der Isar, Technische Universität München (TUM)
City
Muenchen
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinikum rechts der Isar der Technischen Universität München
City
München
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Recruiting
Facility Name
Evangelismos General Hospital of Athens
City
Athens
State/Province
Attikí
ZIP/Postal Code
106 76
Country
Greece
Individual Site Status
Recruiting
Facility Name
Evangelismos Hospital
City
Athens
State/Province
Attikí
ZIP/Postal Code
106 76
Country
Greece
Individual Site Status
Recruiting
Facility Name
Alexandra General Hospital of Athens
City
Athens
State/Province
Attikí
ZIP/Postal Code
115 28
Country
Greece
Individual Site Status
Recruiting
Facility Name
Theageneio Cancer Hospital of Thessaloniki
City
Thessaloniki
State/Province
Kentrikí Makedonía
ZIP/Postal Code
546 39
Country
Greece
Individual Site Status
Recruiting
Facility Name
University General Hospital of Ioannina
City
Ioannina
Country
Greece
Individual Site Status
Recruiting
Facility Name
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
City
Meldola
State/Province
Emilia-romagna
ZIP/Postal Code
47014
Country
Italy
Individual Site Status
Recruiting
Facility Name
Ospedale San Martino
City
Genova
State/Province
Liguria
ZIP/Postal Code
16132
Country
Italy
Individual Site Status
Recruiting
Facility Name
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20122
Country
Italy
Individual Site Status
Recruiting
Facility Name
Fondazione IRCCS San Gerardo dei Tintori
City
Monza
State/Province
Lombardia
ZIP/Postal Code
20900
Country
Italy
Individual Site Status
Not yet recruiting
Facility Name
ASST Santi Paolo e Carlo Ospedale San Carlo Borromeo SSD di Onco-Ematologia (Edificio C-piano terra)
City
Milano
State/Province
Milan
ZIP/Postal Code
20153
Country
Italy
Individual Site Status
Recruiting
Facility Name
Policlinico "G. Rodolico"
City
Catania
State/Province
Sicilia
ZIP/Postal Code
95123
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azienda Ospedaliero Universitaria Senese
City
Siena
State/Province
Toscana
ZIP/Postal Code
53100
Country
Italy
Individual Site Status
Recruiting
Facility Name
IRCCS - AOU di Bologna
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Recruiting
Facility Name
AOU Policlinico Umberto I
City
Roma
ZIP/Postal Code
00161
Country
Italy
Individual Site Status
Recruiting
Facility Name
Fondazione Policlinico Universitario Agostino Gemelli
City
Roma
ZIP/Postal Code
00168
Country
Italy
Individual Site Status
Recruiting
Facility Name
Nagoya City University Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
467-8602
Country
Japan
Individual Site Status
Recruiting
Facility Name
Toyohashi Municipal Hospital
City
Toyohashi
State/Province
Aichi
ZIP/Postal Code
441-8570
Country
Japan
Individual Site Status
Recruiting
Facility Name
University of Fukui Hospital
City
Yoshida-gun
State/Province
Fukui
ZIP/Postal Code
910-1193
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization Shibukawa Medical Center
City
Shibukawa
State/Province
Gunma
ZIP/Postal Code
377-0280
Country
Japan
Individual Site Status
Recruiting
Facility Name
Iwate Medical University Hospital
City
Yahaba-cho, Shiwa-gun
State/Province
Iwate
ZIP/Postal Code
028-3695
Country
Japan
Individual Site Status
Recruiting
Facility Name
Tohoku University Hospital
City
Sendai
State/Province
Miyagi
ZIP/Postal Code
980-8574
Country
Japan
Individual Site Status
Recruiting
Facility Name
Hamamatsu University Hospital
City
Hamamatsu
State/Province
Shizuoka
ZIP/Postal Code
431-3192
Country
Japan
Individual Site Status
Recruiting
Facility Name
Shizuoka Cancer Center
City
Sunto-gun
State/Province
Shizuoka
ZIP/Postal Code
411-8777
Country
Japan
Individual Site Status
Recruiting
Facility Name
Japanese Red Cross Medical Center
City
Shibuya-ku
State/Province
Tokyo
ZIP/Postal Code
150-8935
Country
Japan
Individual Site Status
Recruiting
Facility Name
Akita University Hospital
City
Akita
ZIP/Postal Code
010-8543
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization Kyushu Cancer Center
City
Fukuoka
ZIP/Postal Code
811-1395
Country
Japan
Individual Site Status
Recruiting
Facility Name
Kyushu University Hospital
City
Fukuoka
ZIP/Postal Code
812-8582
Country
Japan
Individual Site Status
Recruiting
Facility Name
Kagoshima University Hospital
City
Kagoshima
ZIP/Postal Code
890-8520
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization Kumamoto Medical Center
City
Kumamoto
ZIP/Postal Code
860-0008
Country
Japan
Individual Site Status
Recruiting
Facility Name
Nagasaki University Hospital
City
Nagasaki
ZIP/Postal Code
852-8501
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization Okayama Medical Center
City
Okayama
ZIP/Postal Code
701-1192
Country
Japan
Individual Site Status
Recruiting
Facility Name
Osaka Metropolitan University Hospital
City
Osaka
ZIP/Postal Code
545-8586
Country
Japan
Individual Site Status
Recruiting
Facility Name
Tokushima University Hospital
City
Tokushima
ZIP/Postal Code
770-8503
Country
Japan
Individual Site Status
Recruiting
Facility Name
Yamagata University Hospital
City
Yamagata
ZIP/Postal Code
990-9585
Country
Japan
Individual Site Status
Recruiting
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
State/Province
Gyeonggi-do
ZIP/Postal Code
13620
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Chonnam National University Hwasun Hospital
City
Hwasun-gun
State/Province
Jeonranamdo
ZIP/Postal Code
58128
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Pusan National University Hospital
City
Busan
State/Province
Pusan-kwangyǒkshi
ZIP/Postal Code
49241
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Seoul National University Hospital
City
Seoul
State/Province
Seoul-teukbyeolsi [seoul]
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Samsung Medical Center
City
Seoul
State/Province
Seoul-teukbyeolsi [seoul]
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
The Catholic Univ. of Korea Seoul St. Mary's Hospital
City
Seoul
State/Province
Seoul-teukbyeolsi [seoul]
ZIP/Postal Code
06591
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Kyungpook National University Hospital
City
Daegu
State/Province
Taegu-kwangyǒkshi
ZIP/Postal Code
41944
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Kyungpook National University Hospital
City
Daegu
ZIP/Postal Code
41944
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
21565
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Hematológica Alta Especialidad SC, consultorio 830
City
Colonia Valle De Las Palmas, Huixquilucan
State/Province
México
ZIP/Postal Code
52787
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
City
Monterrey
State/Province
Nuevo LEÓN
ZIP/Postal Code
66460
Country
Mexico
Individual Site Status
Not yet recruiting
Facility Name
Centro de Investigacion Clinica de Oaxaca
City
Oaxaca
ZIP/Postal Code
68020
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Instituto Veracruzano en Investigación Clínica S.C.
City
Veracruz
ZIP/Postal Code
91851
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Erasmus Universitair Medisch Centrum
City
Rotterdam
State/Province
Zuid-holland
ZIP/Postal Code
3015 GD
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Maastricht University Medical Center
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
North Shore Hospital
City
Auckland
ZIP/Postal Code
0620
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
North Shore Hospital
City
Auckland
ZIP/Postal Code
0622
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Aotearoa Clinical Trials
City
Auckland
ZIP/Postal Code
2025
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Middlemore Clinical Trials
City
Auckland
ZIP/Postal Code
2025
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Waikato Hospital
City
Hamilton
ZIP/Postal Code
3204
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Palmerston North Hospital
City
Roslyn
ZIP/Postal Code
4414
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Capital, Coast and Hutt Valley District - Wellington Regional Hospital
City
Wellington
ZIP/Postal Code
6021
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Haukeland Universitetssjukehus
City
Bergen
State/Province
Hordaland
ZIP/Postal Code
5021
Country
Norway
Individual Site Status
Recruiting
Facility Name
Stavanger Universitetssykehus
City
Stavanger
State/Province
Rogaland
ZIP/Postal Code
4011
Country
Norway
Individual Site Status
Recruiting
Facility Name
Oslo Universitetssykehus Ullevål
City
Oslo
ZIP/Postal Code
0450
Country
Norway
Individual Site Status
Recruiting
Facility Name
St Olavs Hospital
City
Trondheim
ZIP/Postal Code
7030
Country
Norway
Individual Site Status
Recruiting
Facility Name
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy Klinika Hematologii
City
Bydgoszcz
ZIP/Postal Code
85-168
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy
City
Bydgoszcz
ZIP/Postal Code
85-168
Country
Poland
Individual Site Status
Recruiting
Facility Name
Uniwersyteckie Centrum Kliniczne
City
Gdansk
ZIP/Postal Code
80-214
Country
Poland
Individual Site Status
Recruiting
Facility Name
Pratia Onkologia Katowice
City
Katowice
ZIP/Postal Code
40-519
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu
City
Poznan
ZIP/Postal Code
60-569
Country
Poland
Individual Site Status
Recruiting
Facility Name
Centrum Medyczne Pratia Poznan
City
Skorzewo
ZIP/Postal Code
60-185
Country
Poland
Individual Site Status
Recruiting
Facility Name
Uniwersyteckie Centrum Kliniczne WUM Centralny Szpital Kliniczny
City
Warszawa
ZIP/Postal Code
02-097
Country
Poland
Individual Site Status
Recruiting
Facility Name
Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku
City
Wroclaw
ZIP/Postal Code
50-367
Country
Poland
Individual Site Status
Recruiting
Facility Name
Complejo Hospitalario Universitario de Santiago
City
Santiago de Compostela
State/Province
A Coruna
ZIP/Postal Code
15706
Country
Spain
Individual Site Status
Recruiting
Facility Name
Institut Català d'Oncologia - L'Hospitalet
City
L'Hospitalet Del Llobregat
State/Province
Barcelona [barcelona]
ZIP/Postal Code
08908
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Mutua Terrassa
City
Terrassa
State/Province
Barcelona
ZIP/Postal Code
08221
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Marqués de Valdecilla
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
Individual Site Status
Recruiting
Facility Name
Clinica Universidad de Navarra
City
Madrid
State/Province
Madrid, Comunidad DE
ZIP/Postal Code
28027
Country
Spain
Individual Site Status
Recruiting
Facility Name
Clinica Universidad de Navarra
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario de Toledo
City
Toledo
State/Province
Other
ZIP/Postal Code
45007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitari Vall d'Hebron
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Clinic Barcelona
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Reina Sofía
City
Cordoba
ZIP/Postal Code
14004
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitari De Girona Doctor Josep Trueta
City
Girona
ZIP/Postal Code
17007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario La Princesa
City
Madrid
ZIP/Postal Code
28006
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Madrid Sanchinarro
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario de Salamanca
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Virgen Del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario y Politecnico La Fe
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Individual Site Status
Recruiting
Facility Name
Helsingborgs Lasarett
City
Helsingborg
State/Province
Skåne LÄN [se-12]
ZIP/Postal Code
251 87
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Skånes Universitetssjukhus Lund
City
Lund
State/Province
Skåne LÄN [se-12]
ZIP/Postal Code
22185
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Södra Älvsborg Sjukhus
City
Borås
ZIP/Postal Code
501 82
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Falu Lasarett
City
Falun
ZIP/Postal Code
791 82
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Sahlgrenska Universitetssjukhuset
City
Göteborg
ZIP/Postal Code
41345
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Sunderby Sjukhus
City
Luleå
ZIP/Postal Code
971 80
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Universitetssjukhuset Örebro
City
Örebro
State/Province
Örebro LÄN [se-18]
ZIP/Postal Code
701 85
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Universitetssjukhuset i Linköping
City
Linköping
State/Province
Östergötlands LÄN [se-05]
ZIP/Postal Code
581 85
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Chang Gung Memorial Hospital at Kaohsiung
City
Kaohsiung
ZIP/Postal Code
83301
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Cheng Kung University Hospital
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Sisli Florence Nightingale Hastanesi
City
İstanbul / Şişli
State/Province
İ̇stanbul
ZIP/Postal Code
34381
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Istanbul Universitesi Istanbul Tıp Fakultesi Hastanesi
City
Istanbul
State/Province
İ̇stanbul
ZIP/Postal Code
34093
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Medipol Mega Universite Hastanesi
City
İstanbul
State/Province
İ̇stanbul
ZIP/Postal Code
34214
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Acibadem Universitesi Atakent Hastanesi
City
Istanbul
State/Province
İ̇stanbul
ZIP/Postal Code
34303
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Ege Universitesi Hastanesi
City
İzmir
State/Province
İ̇zmir
ZIP/Postal Code
35100
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Dokuz Eylul Universitesi Hastanesi
City
İzmir
State/Province
İ̇zmir
ZIP/Postal Code
35340
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi
City
Adana
ZIP/Postal Code
01240
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Ankara Universitesi Tip Fakultesi Hastanesi
City
Ankara
ZIP/Postal Code
06100
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
City
Ankara
ZIP/Postal Code
06200
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Akdeniz Universitesi Hastanesi
City
Antalya
ZIP/Postal Code
07070
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Aydın Adnan Menderes Universitesi Hastanesi
City
Aydin
ZIP/Postal Code
09100
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
City
Gaziantep
ZIP/Postal Code
27310
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Erciyes Universitesi Tıp Fakultesi Hastaneleri
City
Kayseri
ZIP/Postal Code
38030
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Özel Anadolu Sağlık Merkezi
City
Kocaeli
ZIP/Postal Code
41400
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Inonu Universitesi Turgut Ozal Tıp Merkezi
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Royal Bournemouth Hospital
City
Bournemouth
State/Province
Dorset
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Churchill Hospital
City
Oxford
State/Province
Oxfordshire
ZIP/Postal Code
OX3 7LE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Churchill Hospital, Oxford University Hospitals NHS Foundation Trust
City
Headington
State/Province
Oxford
ZIP/Postal Code
OX3 7LE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
University Hospital of Wales
City
Cardiff
State/Province
South Glamorgan
ZIP/Postal Code
CF14 4XW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Bristol Haematology and Oncology Centre
City
Bristol
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Kent and Canterbury Hospital
City
Canterbury
ZIP/Postal Code
CT1 3NG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
The Christie NHS Foundation Trust
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Recruiting

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
IPD Sharing URL
https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests
Links:
URL
https://pmiform.com/clinical-trial-info-request?StudyID=C1071005
Description
To obtain contact information for a study center near you, click here.

Learn more about this trial

MagnetisMM-5: Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

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