Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients
Cancer
About this trial
This is an interventional supportive care trial for Cancer focused on measuring Pneumonia
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of cancer
- Renal and hepatic function (creatinine </= 2 x the institutional upper limit of normal; bilirubin </= 2 x the institutional upper limit of normal)
- No contraindication to receive either of the planned interventions of inspiratory resistance training or 1,25(OH)2D3 in the opinion of the healthcare provider
- No difficulties with swallowing oral medications in the opinion of the enrolling physician
Exclusion Criteria:
- Patient is taking calcium or Vitamin D supplements and is unwilling to stop for 8 weeks
- Severe chronic obstructive pulmonary disease (oxygen dependent or patient self-reports unable to walk one block without difficulty)
- Calcium or phosphorus level above the institutional upper limit of normal
Sites / Locations
- Mayo Clinic in Rochester
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
Training and Placebo
Sham Training and Vitamin D3 Metabolite
Training and Vitamin D3 Metabolite
Sham Training and Placebo
Inspiratory isometric resistance training with the Threshold Inspiratory Muscle Trainer (IMT) plus oral placebo for eight weeks
Sham inspiratory isometric resistance training with the Threshold Inspiratory Muscle Trainer (IMT) plus 1,25 (OH)2 D3 orally for eight weeks
Inspiratory isometric resistance training with the Threshold Inspiratory Muscle Trainer (IMT) plus 1,25(OH)2 D3 orally for eight weeks
Sham inspiratory isometric resistance training with the Threshold Inspiratory Muscle Trainer (IMT) plus oral placebo orally for eight weeks