Maintaining Abstinence in Chronic Cigarette Smokers - 1

Subjects (N=400) will be men and women (50%) over the age of 18 who smoke at least 10 cigarettes per day and answers yes to the question "Do you smoke within 30 minutes of arising?" Inclusion Criteria: -Subjects are age 18 and over, currently smoking 10 or more cigarettes per day, and report a smoking history of at least 5 years in response to the question "How long have you been a regular smoker?" Exclusion Criteria: History of seizure or head injury resulting in unconsciousness Any condition that might predispose to seizures (brain tumor or stroke) A current or history of anorexia nervosa or bulimia Any disease acutely life-threatening or so severe that the patient is judged unable to comply with the protocol Use of a protease inhibitor of MAO inhibitor within the last two week Current use of psychiatric drugs that would interfere with interpretation of study results, including antidepressants Treatment for alcohol dependence during the last year, or evidence of alcohol abuse so severe that the patient is judged potentially unable to comply with the protocol Patients who know they are leaving the Bay Area within the study period and non-English speakers will be excluded Suicidal or homicidal ideation Current major depression History of bipolar disorder Recent (within twelve months) myocardial infarction Any other medical condition that would contraindicate use of NRT or bupropion Physical limitation so severe that participation in a program of moderate exercise is not possible Pregnancy or lactation