Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer (MeaTIc)
Nutrition Aspect of Cancer, Diet Modification, Cancer of Colon
About this trial
This is an interventional prevention trial for Nutrition Aspect of Cancer focused on measuring vegetarian, meat, fish
Eligibility Criteria
Inclusion Criteria:
- clinically healthy (both sexes)
- age >18 years and ≤ 50 years.
The study population will be selected with an age ranging from 18 to 50 years because after 50 years the risk for CRC shows a significant increase in incidence. In fact, more than 90% of the people diagnosed with the disease are older than 50, with the average age at the time of diagnosis being 64 (Amersi et al., 2005). With respect to gender, its role in the development of colorectal cancer remains unclear (Amersi et al., 2005).
Exclusion Criteria:
- Presence of current illness or unstable conditions
- Current or recent (past 2 months) use of antibiotics or probiotics
- Pregnancy or intention to become pregnant in the next 12 months or lactation
- Current smoking habit
- Current or recent (past 2 months) adoption of a vegetarian diet
Sites / Locations
- Unit of Clinical Nutrition, University Hospital of Careggi
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Meat-based diet (MBD)
Meat-based alpha-tocopherol (MBD-T)
Pesco-vegetarian (PVD)
Behavioral intervention with diet including 4 servings per week of red meat, 3 servings per week of processed meat, and 1 servings per week of poultry, for a total amount of 900 g per week of meat.
Behavioral intervention including diet with 4 servings per week of red meat, 3 servings per week of processed meat, and 1 servings per week of poultry, for a total amount of 900 g per week of meat with a dietary supplement of 100 mg/day of alpha-tocopherol in the form of tablet
Behavioral intervention with diet excluding fresh and processed meat, poultry but including 3 servings per week of any type of fish, excluding shellfish