Melatonin vs Sleep Deprivation for Nap EEG
Epilepsy
About this trial
This is an interventional treatment trial for Epilepsy focused on measuring Oral melatonin, Sleep deprivation, Nap EEG recordings, Time to fall asleep
Eligibility Criteria
Inclusion Criteria: pediatric patients with epilepsy aged between 4 and 10 years with normal psychomotor development and IQ> 70; stable seizure frequency in the 3 months preceding the enrollment ; stable anti-seizure medications in the 3 months preceding the enrollment; written informed consent from the legal representative. Exclusion Criteria: subjects diagnosed with obstructive sleep apnea or other sleep disorders; history of neurodevelopmental disorders; concomitant use of hypnotics, stimulants, systemic corticosteroids or other immunosuppressants; concomitant daily use of melatonin; any conditions which, in the investigator's judgment, would compromise the achievement of the study objectives; refusal to sign the informed consent from the legal representative.
Sites / Locations
- Child and Adolescent Epileptology Center
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Deprivation group
Melatonin group
Sleep deprivation of 50% of physiological sleep
Melatonin oral solution 5 mg 30 minutes before EEG performing