search
Back to results

Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA) (MIRNA)

Primary Purpose

Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis With Liver Fibrosis

Status
Active
Phase
Phase 2
Locations
International
Study Type
Interventional
Intervention
Placebo
PF-06865571
PF-05221304
Sponsored by
Pfizer
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Nonalcoholic Fatty Liver Disease

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Biopsy proven NASH with either F2 or F3 fibrosis, per NASH CRN definition
  • BMI >/= 22.5kg/m2

Exclusion Criteria:

  • Evidence of other causes of liver disease such as Alcoholic steatohepatitis, (de)compensated cirrhosis, active viral hepatitis
  • Any condition possibly affecting drug absorption -Unstable concomitant medical conditions, based on medical history or screening laboratory results including-
  • unstable liver function tests, recent cardiovascular event(s) significant malignancies,

Sites / Locations

  • Institute for Liver Health dba Arizona Liver Health
  • Comprehensive Interventional Care Centers (CICC)
  • The Institute for Liver Health
  • The Institute for Liver Health
  • Comprehensive Interventional Care Centers (CICC)
  • Institute for Liver Health DBA Arizona Liver Health
  • Hope Clinical Research
  • Sharp Coronado Hospital
  • Southern California Research Center
  • Magnolia Surgery Center
  • Encino Hospital Medical Center
  • National Research Institute
  • Altman Clinical and Translational Research Institute (ACTRI)
  • Investigational Drug Service, Altman Clinical and Translational Research Institute (ACTRI)
  • University of California San Diego, Altman Clinical and Translational Research Institute Clinic
  • UCSD Altman Clinical and Transitional Research Institute
  • A V Pediatrics, Allergy & Family Medicine
  • Jatinder S. Pruthi, M.D. FACG CPI
  • Om Research LLC
  • Kaiser Permanente Los Angeles Medical Center
  • Cedars-Sinai Advanced Health Sciences Pavilion (Imaging)
  • Cedars-Sinai Comprehensive Transplant Center
  • Cedars-Sinai Medical Center Investigational Drug Services (Pharmacy)
  • S. Mark Taper Foundation Imaging Center (Liver Biopsy)
  • Providence Facey Medical Foundation
  • Providence Holy Cross Medical Center
  • ART Vascular
  • ART Vascular
  • United Medical Doctors
  • Back Bay Imaging (Liver Biopsy)
  • Advanced Imaging Center
  • Blake Wilbur Outpatient Clinic (MRI)
  • Stanford Hospital and Clinics
  • Huntington-Hill Imaging Center, Cordova
  • California Liver Research Institute
  • HMRI
  • Huntington Medical Research Institute
  • Huntington-Hill Imaging Center, Fair Oaks
  • Stanford Medicine Outpatient Center (Liver clinic/MRI)
  • Inland Empire Clinical Trials, LLC
  • Clinical Trials Research
  • Precision Research Institute
  • WR-MCCR
  • Sharp and Children's MRI Center, LLC
  • Stanford Cancer Center South Bay (MRI)
  • Liberty Pacific Advanced Imaging
  • Orange County Research Center
  • Upland Clinical Research
  • Bristol Hospital
  • Bristol Radiology Center
  • Connecticut Clinical Research Institute, LLC
  • Yale New Haven Hospital
  • Yale New Haven Hospital, Saint Raphael Campus (MRE location)
  • Yale Center for Clinical Investigators, Church Street South Research Unit (CSRU)
  • Yale Digestive Diseases (Fibroscan location)
  • Tower Radiology (MRI-PDFF)
  • Tower Radiology - Parsons
  • Gastro Florida
  • Gastro Florida
  • Integrity Clinical Research, LLC
  • Mayo Clinic Florida
  • FDHS Pathology Lab
  • Florida Research Institute
  • Center for Advanced Gastroenterology
  • Sandlake Imaging
  • San Marcus Research Clinic, Inc.
  • Optimus U Corporation
  • Unique Imaging (Biscayne Imaging Center)
  • Acevedo Clinical Research Associates
  • Ivetmar Medical Group LLC
  • Vascular and Interventional Specialists of Florida (Liver Biopsy)
  • Care Research Center Inc
  • TGH Imaging Powered by Tower Radiology Center (MRI)
  • Clinical Neuroscience Solutions, Inc
  • Omega Research Maitland, LLC
  • Innovation Medical Research Center, Inc
  • GCP, Global Clinical Professionals
  • Gateway (Ultrasound)
  • Partners Imaging Center
  • Radiology Associates
  • Center for Clinical Studies
  • AdventHealth Zephyrhills
  • Florida Medical Clinic, LLC
  • Digestive Healthcare of Georgia
  • Piedmont Atlanta Hospital/Piedmont Transplant Institute
  • Piedmont Atlanta Hospital
  • Columbus Regional Research Institute
  • WR-Mount Vernon Clinical Research, LLC
  • Tekton Research, Inc.
  • Rush University Medical Center
  • Investigators Research Group, LLC
  • Hendricks Regional Health
  • Heartland Medical Research, Inc. (Administrative Only)
  • Iowa Digestive Disease Center
  • Iowa Radiology
  • MercyOne Des Moines Medical Center (Mercy Medical Center)
  • University of Iowa Hospitals and Clinics
  • University of Iowa Magnetic Resonance Research Facility
  • Kansas Medical Clinic PA
  • Alliance for Multispecialty Research, LLC
  • Cypress Interventional
  • Centex Studies, Inc.
  • Lake Charles Memorial Hospital
  • Metropolitan Gastroenterology Associates
  • Tandem Clinical Research GI, LLC
  • Ochsner Clinic Foundation
  • Louisiana Research Center, LLC
  • Gastro Health Research
  • Gastro Center of Maryland
  • Beth Israel Deaconess Medical Center
  • Michigan Clinical Research Unit (MCRU)
  • University of Michigan
  • Henry Ford Health System
  • Aa Mrc Llc
  • Mercy Health
  • M1 Imaging Center
  • Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
  • Mayo Clinic
  • Jefferson City Medical Group, P.C.
  • Desert Radiology
  • Machuca Family Medicine
  • The Machuca Foundation, Inc.
  • Sierra Clinical Research
  • Las Vegas Medical Research
  • Pueblo Medical Imaging
  • Digestive Healthcare Associates
  • University Radiology
  • Amici Clinical Research
  • Northwell Health Center for Liver Diseases
  • Icahn School of Medicine at Mount Sinai Beth Israel
  • Mount Sinai Downtown Union Square
  • Hess Building- CMS
  • Icahn School of Medicine at Mount Sinai/The Mount Sinai Hospital
  • The Mount Sinai Hospital: Department of Pharmacy
  • M3-Wake Research, Inc.
  • Gastroenterology Associates of the Piedmont, PA
  • Novant Health Medical Center
  • PMG Research of Winston-Salem, LLC
  • Paramount Medical Research & Consulting, LLC
  • Comprehensive Diagnostic Imaging
  • Digestive Disease Specialists, Inc. Endoscopy Lab
  • Digestive Disease Specialists, Inc.
  • Oklahoma Spine Hospital
  • Thomas Jefferson University
  • UPMC - Center for Liver Diseases at the Thomas E. Starzl Institute
  • UPMC - Center for Liver Diseases in the Digestive Disorders Clinic
  • UPMC - Translational Research Center
  • UPMC Presbyterian Shadyside; Presbyterian Campus Pharmacy
  • UPMC
  • University Gastroenterology
  • Roger Williams Hospital
  • Medical University of South Carolina
  • MUSC- Ashley River Tower
  • Chattanooga Imaging Center
  • WR-Clinsearch, LLC
  • Quality Medical Research, PLLC
  • Vanderbilt University Medical Center - GI Research Office
  • Vanderbilt Hepatology and Liver Transplant
  • Vanderbilt University Medical Center - Digestive Disease Center
  • Vanderbilt University Medical Center - Heart Station
  • Vanderbilt University Medical Center - Interventional Radiology
  • Texas Center for Interventional Surgery (Liver Biopsy Facility)
  • Texas Clinical Research Institute
  • Methodist Dallas Medical Center (Liver Biopsy)
  • Methodist Dallas Medical Center (MRI-PDFF)
  • The Liver Institute at Methodist Dallas Medical Center
  • Touchstone Imaging
  • Center For Diagnostic Imaging
  • GI Alliance
  • Therapeutic Concepts, PA
  • Centex Studies, Inc.
  • Biopharma Informatic, LLC
  • Premier Vein and Vascular
  • Centex Studies, Inc
  • HCA Houston Healthcare Pearland
  • American Research Corporation at the Texas Liver Institute
  • Clinical Trials of Texas, Inc.
  • Diabetes and Glandular Disease Clinic, P.A.
  • Reddy Cardiac Wellness
  • Impact Research Institute
  • Gastro Health Research
  • Manassas Clinical Research Center
  • Digestive and Liver Disease Specialists
  • Sentara Leigh Hospital
  • McGuire VA Medical Center
  • VCU Medical Center Investigational Drug Service
  • Virginia Commonwealth University
  • Virginia Gastroenterology Clinical Research
  • Harborview Medical Center Investigational Drug Services
  • Harborview Medical Center
  • Seattle Radiology
  • Liver Institute Northwest
  • Swedish Medical Center
  • University of Washington Medical Center
  • MHAT Dr. Tota Venkova AD
  • MHAT Medline Clinic AD
  • Acibadem City Clinic MHAT Tokuda EAD
  • DCC Alexandrovska EOOD
  • UMHAT Alexandrovska EAD
  • UMHAT Sv. Ivan Rilski EAD
  • UMHAT Sofiamed OOD
  • MC New Rehabilitation Center EOOD
  • DCC Mladost-M Varna OOD
  • MC VIP Clinic OOD
  • University of Calgary - Heritage Medical Research Clinic (HMRC)
  • University of Alberta Hospital
  • University of Alberta
  • Gordon and Leslie Diamond Health Care Centre
  • (G.I.R.I.) GI Research Institute
  • Nova Scotia Health Authority QEII (Queen Elizabeth II) Health Sciences Centre
  • Manna Research (London)
  • Toronto Liver Centre
  • Resonance Magnetique du Saguenay-Lac-Saint-Jean
  • Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean
  • Ecogene-21
  • McGill University Health Centre (MUHC)
  • Philips Radiation Oncology
  • Research Institute of the MUHC
  • Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM)
  • Diex Recherche Quebec Inc.
  • Beijing Friendship Hospital, Capital Medical University
  • The First Affiliated Hospital, Sun Yat-sen University
  • The Third Hospital of Hebei Medical University
  • Hunan Provincial People's Hospital
  • The First Bethune Hospital of Jilin University
  • General Hospital of Ningxia Medical University
  • Qingdao Central Hospital
  • The Affiliated Hospital of Hangzhou Normal University
  • The First Affiliated Hospital of Wenzhou Medical University
  • Peking University People's Hospital
  • Beijing YouAn Hosptial,Capital Medical University
  • Beijing Tsinghua Changgung Hospital
  • Tianjin Third Central Hospital
  • Tianjin Second People's Hospital
  • Queen Mary Hospital
  • Prince of Wales Hospital
  • Alice Ho Miu Ling Nethersole Hospital
  • Surat Institute of Digestive Sciences
  • Gujarat Hospital - Gastro and Vascular Centre
  • Global Hospital - Super Speciality & Transplant Centre
  • Max Smart Super Speciality Hospital
  • S.M.S. Medical College & Hospital
  • Institute of Post Graduate Medical Education and Research & SSKM Hospital
  • Medanta - The Medicity
  • Institute of Liver and Biliary Sciences (ILBS)
  • All India Institute of Medical Sciences (AIIMS)
  • Aichi Medical University Hospital
  • Ehime University Hospital
  • Ogaki Municipal Hospital
  • Tokyo Medical University Ibaraki Medical Center
  • Kagawa Prefectural Central Hospital
  • Yokohama City University Hospital
  • Shinshu University Hospital
  • National Hospital Organization Nagasaki Medical Center
  • Osaka Rosai Hospital
  • Saiseikai Suita Hospital
  • Juntendo University Shizuoka Hospital
  • Chiba University Hospital
  • Fukui-Ken Saiseikai Hospital
  • Gifu Municipal Hospital
  • Kagoshima University Hospital
  • University Hospital, Kyoto Prefectural University of Medicine
  • Miyazaki Medical Center Hospital
  • Saga University Hospital
  • Yamagata University Hospital
  • SMG-SNU Boramae Medical Center
  • Pusan National University Hospital
  • Kyungpook National University Hospital
  • Yeungnam University Hospital
  • Severance Hospital Yonsei University Health System
  • Szpital Zakonu Bonifratrow
  • NZOZ Vita Longa Sp. z o.o.
  • Uniwersyteckie Centrum Kliniczne im. prof. K. Gibinskiego Slaskiego Uniwersytetu Medycznego
  • Orthos Szpital Wielospecjalistyczny Sp. z o.o. (Liver Biopsy)
  • SPZOZ Szpital Uniwersytecki w Krakowie
  • Szpital Zakonu Bonifratrów św. Jana Grandego w Krakowie sp. z o.o. (Liver Biopsy)
  • Krakowskie Centrum Medyczne
  • Wojewodzki Specjalistyczny Szpital im. Dr. Wl. Bieganskiego w Lodzi
  • ID Clinic
  • WIP Warsaw IBD Point Profesor Kierkus
  • Futuremeds Sp. z o.o.
  • ETG Zamo??
  • ETG Zamosc
  • Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
  • Clinical Research Puerto Rico
  • Latin Clinical Trial Center
  • GCM Medical Group PSC
  • FDI Clinical Research
  • Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica
  • SUMMIT CLINICAL RESEARCH, s.r.o.
  • Lama Medical Care s.r.o.
  • Medispektrum, s.r.o
  • Univerzitna nemocnica L. Pasteura Kosice
  • KM Management spol. s.r.o., Gastroenterologicke a hepatologicke centrum Nitra
  • Fakultna nemocnica Nitra
  • JAL, s.r.o.
  • Changhua Christian Hospital
  • Ditmanson Medical Foundation Chia-Yi Christian Hospital
  • Kaohsiung Medical University Chung-Ho Memorial Hospital
  • National Cheng Kung University (NCKU) Hospital
  • National Taiwan University Hospital
  • Taipei Veterans General Hospital
  • Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm 7

Arm Type

Placebo Comparator

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Arm Label

Placebo

PF-06865571 25 milligrams (mg) twice daily (BID)

PF-06865571 75 mg BID

PF-06865571 150 mg BID

PF-06865571 300 mg BID

PF-06865571 (150 mg BID) + PF-05221304 (5 mg BID)

PF-06865771 (300 mg BID) + PF-05221304 (10 mg BID)

Arm Description

participants will receive medication for 48 weeks

participants will receive medication for 48 weeks

participants will receive medication for 48 weeks

participants will receive medication for 48 weeks

participants will receive medication for 48 weeks

participants will receive medication for 48 weeks

participants will receive medication for 48 weeks

Outcomes

Primary Outcome Measures

Resolution of NASH without worsening of fibrosis or improvement in fibrosis by 1>/= or both
Proportion of participants achieving resolution of NASH without worsening of fibrosis or improvement in fibrosis by ≥1 stage without worsening of NASH or both

Secondary Outcome Measures

Percent change in liver fat
Percent change in liver fat (assessed via MRI-PDFF)
Proportion of participants achieving Resolution of NASH, without worsening of fibrosis
Proportion of participants achieving improvement in fibrosis by ≥1stage, without worsening of NASH
Proportion of participants with Improvement in fibrosis by ≥2 stages, without worsening of NASH
Proportion of participants with Improvement of ≥2 points in Total NASH
Proportion of participants with a clinically significant change from baseline in vital signs
Proportion of participants with a clinically significant change from baseline in laboratory values
Proportion of participants with a clinically significant change from baseline in electrocardiograms (ECG) parameters
Proportion of participants with treatment-emergent adverse events (TEAE)

Full Information

First Posted
March 23, 2020
Last Updated
September 15, 2023
Sponsor
Pfizer
search

1. Study Identification

Unique Protocol Identification Number
NCT04321031
Brief Title
Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)
Acronym
MIRNA
Official Title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO-CONTROLLED, DOSE-RANGING, DOSE-FINDING, PARALLEL GROUP STUDY TO ASSESS EFFICACY AND SAFETY OF PF-06865571 (DGAT2I) ALONE AND WHEN COADMINISTERED WITH PF-05221304 (ACCI) IN ADULT PARTICIPANTS WITH BIOPSY-CONFIRMED NONALCOHOLIC STEATOHEPATITIS AND FIBROSIS STAGE 2 OR 3
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
June 15, 2020 (Actual)
Primary Completion Date
January 24, 2024 (Anticipated)
Study Completion Date
February 22, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Pfizer

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The study aims to evaluate two, orally administered, investigational agents - PF-06865571 (DGAT2 inhibitor) and the coadministration of PF-06865571 with PF-05221304 (ACC inhibitor). This study is specifically designed to evaluate the effect of a range of doses of DGAT2i alone, and DGAT2i + ACCi, on resolution of NASH or improvement in liver fibrosis, as assessed histologically (via liver biopsy).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis With Liver Fibrosis

7. Study Design

Primary Purpose
Basic Science
Study Phase
Phase 2
Interventional Study Model
Parallel Assignment
Model Description
dose ranging, dose finding
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Double blind, double dummy, placebo controlled
Allocation
Randomized
Enrollment
258 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
participants will receive medication for 48 weeks
Arm Title
PF-06865571 25 milligrams (mg) twice daily (BID)
Arm Type
Experimental
Arm Description
participants will receive medication for 48 weeks
Arm Title
PF-06865571 75 mg BID
Arm Type
Experimental
Arm Description
participants will receive medication for 48 weeks
Arm Title
PF-06865571 150 mg BID
Arm Type
Experimental
Arm Description
participants will receive medication for 48 weeks
Arm Title
PF-06865571 300 mg BID
Arm Type
Experimental
Arm Description
participants will receive medication for 48 weeks
Arm Title
PF-06865571 (150 mg BID) + PF-05221304 (5 mg BID)
Arm Type
Experimental
Arm Description
participants will receive medication for 48 weeks
Arm Title
PF-06865771 (300 mg BID) + PF-05221304 (10 mg BID)
Arm Type
Experimental
Arm Description
participants will receive medication for 48 weeks
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Tablet
Intervention Type
Drug
Intervention Name(s)
PF-06865571
Intervention Description
Tablet
Intervention Type
Drug
Intervention Name(s)
PF-05221304
Intervention Description
Tablet
Primary Outcome Measure Information:
Title
Resolution of NASH without worsening of fibrosis or improvement in fibrosis by 1>/= or both
Description
Proportion of participants achieving resolution of NASH without worsening of fibrosis or improvement in fibrosis by ≥1 stage without worsening of NASH or both
Time Frame
Week 48
Secondary Outcome Measure Information:
Title
Percent change in liver fat
Description
Percent change in liver fat (assessed via MRI-PDFF)
Time Frame
Week 48
Title
Proportion of participants achieving Resolution of NASH, without worsening of fibrosis
Time Frame
Week 48
Title
Proportion of participants achieving improvement in fibrosis by ≥1stage, without worsening of NASH
Time Frame
Week 48
Title
Proportion of participants with Improvement in fibrosis by ≥2 stages, without worsening of NASH
Time Frame
Week 48
Title
Proportion of participants with Improvement of ≥2 points in Total NASH
Time Frame
Week 48
Title
Proportion of participants with a clinically significant change from baseline in vital signs
Time Frame
Baseline to Week 50
Title
Proportion of participants with a clinically significant change from baseline in laboratory values
Time Frame
Baseline to Week 50
Title
Proportion of participants with a clinically significant change from baseline in electrocardiograms (ECG) parameters
Time Frame
Baseline to Week 50
Title
Proportion of participants with treatment-emergent adverse events (TEAE)
Time Frame
Baseline to Week 52

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Biopsy proven NASH with either F2 or F3 fibrosis, per NASH CRN definition BMI >/= 22.5kg/m2 Exclusion Criteria: Evidence of other causes of liver disease such as Alcoholic steatohepatitis, (de)compensated cirrhosis, active viral hepatitis Any condition possibly affecting drug absorption -Unstable concomitant medical conditions, based on medical history or screening laboratory results including- unstable liver function tests, recent cardiovascular event(s) significant malignancies,
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Pfizer CT.gov Call Center
Organizational Affiliation
Pfizer
Official's Role
Study Director
Facility Information:
Facility Name
Institute for Liver Health dba Arizona Liver Health
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Facility Name
Comprehensive Interventional Care Centers (CICC)
City
Gilbert
State/Province
Arizona
ZIP/Postal Code
85233
Country
United States
Facility Name
The Institute for Liver Health
City
Glendale
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
The Institute for Liver Health
City
Peoria
State/Province
Arizona
ZIP/Postal Code
85381
Country
United States
Facility Name
Comprehensive Interventional Care Centers (CICC)
City
Sun City
State/Province
Arizona
ZIP/Postal Code
85351
Country
United States
Facility Name
Institute for Liver Health DBA Arizona Liver Health
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85712
Country
United States
Facility Name
Hope Clinical Research
City
Canoga Park
State/Province
California
ZIP/Postal Code
91303
Country
United States
Facility Name
Sharp Coronado Hospital
City
Coronado
State/Province
California
ZIP/Postal Code
92118
Country
United States
Facility Name
Southern California Research Center
City
Coronado
State/Province
California
ZIP/Postal Code
92118
Country
United States
Facility Name
Magnolia Surgery Center
City
El Cajon
State/Province
California
ZIP/Postal Code
92020
Country
United States
Facility Name
Encino Hospital Medical Center
City
Encino
State/Province
California
ZIP/Postal Code
91436
Country
United States
Facility Name
National Research Institute
City
Huntington Park
State/Province
California
ZIP/Postal Code
90255
Country
United States
Facility Name
Altman Clinical and Translational Research Institute (ACTRI)
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Investigational Drug Service, Altman Clinical and Translational Research Institute (ACTRI)
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
University of California San Diego, Altman Clinical and Translational Research Institute Clinic
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
UCSD Altman Clinical and Transitional Research Institute
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
A V Pediatrics, Allergy & Family Medicine
City
Lancaster
State/Province
California
ZIP/Postal Code
93534
Country
United States
Facility Name
Jatinder S. Pruthi, M.D. FACG CPI
City
Lancaster
State/Province
California
ZIP/Postal Code
93534
Country
United States
Facility Name
Om Research LLC
City
Lancaster
State/Province
California
ZIP/Postal Code
93534
Country
United States
Facility Name
Kaiser Permanente Los Angeles Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90027
Country
United States
Facility Name
Cedars-Sinai Advanced Health Sciences Pavilion (Imaging)
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Cedars-Sinai Comprehensive Transplant Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Cedars-Sinai Medical Center Investigational Drug Services (Pharmacy)
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
S. Mark Taper Foundation Imaging Center (Liver Biopsy)
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Providence Facey Medical Foundation
City
Mission Hills
State/Province
California
ZIP/Postal Code
91345
Country
United States
Facility Name
Providence Holy Cross Medical Center
City
Mission Hills
State/Province
California
ZIP/Postal Code
91345
Country
United States
Facility Name
ART Vascular
City
Montebello
State/Province
California
ZIP/Postal Code
90640
Country
United States
Facility Name
ART Vascular
City
Monterey Park
State/Province
California
ZIP/Postal Code
91754
Country
United States
Facility Name
United Medical Doctors
City
Murrieta
State/Province
California
ZIP/Postal Code
92563
Country
United States
Facility Name
Back Bay Imaging (Liver Biopsy)
City
Newport Beach
State/Province
California
ZIP/Postal Code
92660
Country
United States
Facility Name
Advanced Imaging Center
City
Palmdale
State/Province
California
ZIP/Postal Code
93551
Country
United States
Facility Name
Blake Wilbur Outpatient Clinic (MRI)
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
Stanford Hospital and Clinics
City
Palo Alto
State/Province
California
ZIP/Postal Code
94305
Country
United States
Facility Name
Huntington-Hill Imaging Center, Cordova
City
Pasadena
State/Province
California
ZIP/Postal Code
91101
Country
United States
Facility Name
California Liver Research Institute
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
HMRI
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
Huntington Medical Research Institute
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
Huntington-Hill Imaging Center, Fair Oaks
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Facility Name
Stanford Medicine Outpatient Center (Liver clinic/MRI)
City
Redwood City
State/Province
California
ZIP/Postal Code
94063
Country
United States
Facility Name
Inland Empire Clinical Trials, LLC
City
Rialto
State/Province
California
ZIP/Postal Code
92377
Country
United States
Facility Name
Clinical Trials Research
City
Sacramento
State/Province
California
ZIP/Postal Code
95821
Country
United States
Facility Name
Precision Research Institute
City
San Diego
State/Province
California
ZIP/Postal Code
92114
Country
United States
Facility Name
WR-MCCR
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
Sharp and Children's MRI Center, LLC
City
San Diego
State/Province
California
ZIP/Postal Code
92123-2731
Country
United States
Facility Name
Stanford Cancer Center South Bay (MRI)
City
San Jose
State/Province
California
ZIP/Postal Code
95124
Country
United States
Facility Name
Liberty Pacific Advanced Imaging
City
Tarzana
State/Province
California
ZIP/Postal Code
91356
Country
United States
Facility Name
Orange County Research Center
City
Tustin
State/Province
California
ZIP/Postal Code
92780
Country
United States
Facility Name
Upland Clinical Research
City
Upland
State/Province
California
ZIP/Postal Code
91786
Country
United States
Facility Name
Bristol Hospital
City
Bristol
State/Province
Connecticut
ZIP/Postal Code
06010
Country
United States
Facility Name
Bristol Radiology Center
City
Bristol
State/Province
Connecticut
ZIP/Postal Code
06010
Country
United States
Facility Name
Connecticut Clinical Research Institute, LLC
City
Bristol
State/Province
Connecticut
ZIP/Postal Code
06010
Country
United States
Facility Name
Yale New Haven Hospital
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Yale New Haven Hospital, Saint Raphael Campus (MRE location)
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06511
Country
United States
Facility Name
Yale Center for Clinical Investigators, Church Street South Research Unit (CSRU)
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06519
Country
United States
Facility Name
Yale Digestive Diseases (Fibroscan location)
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
Tower Radiology (MRI-PDFF)
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Tower Radiology - Parsons
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Gastro Florida
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Gastro Florida
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33762
Country
United States
Facility Name
Integrity Clinical Research, LLC
City
Doral
State/Province
Florida
ZIP/Postal Code
33122
Country
United States
Facility Name
Mayo Clinic Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Facility Name
FDHS Pathology Lab
City
Lakewood Ranch
State/Province
Florida
ZIP/Postal Code
34202
Country
United States
Facility Name
Florida Research Institute
City
Lakewood Ranch
State/Province
Florida
ZIP/Postal Code
34211
Country
United States
Facility Name
Center for Advanced Gastroenterology
City
Maitland
State/Province
Florida
ZIP/Postal Code
32751
Country
United States
Facility Name
Sandlake Imaging
City
Maitland
State/Province
Florida
ZIP/Postal Code
32751
Country
United States
Facility Name
San Marcus Research Clinic, Inc.
City
Miami Lakes
State/Province
Florida
ZIP/Postal Code
33014
Country
United States
Facility Name
Optimus U Corporation
City
Miami
State/Province
Florida
ZIP/Postal Code
33125
Country
United States
Facility Name
Unique Imaging (Biscayne Imaging Center)
City
Miami
State/Province
Florida
ZIP/Postal Code
33137
Country
United States
Facility Name
Acevedo Clinical Research Associates
City
Miami
State/Province
Florida
ZIP/Postal Code
33142
Country
United States
Facility Name
Ivetmar Medical Group LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33155
Country
United States
Facility Name
Vascular and Interventional Specialists of Florida (Liver Biopsy)
City
Miami
State/Province
Florida
ZIP/Postal Code
33156
Country
United States
Facility Name
Care Research Center Inc
City
Miami
State/Province
Florida
ZIP/Postal Code
33175
Country
United States
Facility Name
TGH Imaging Powered by Tower Radiology Center (MRI)
City
Oldsmar
State/Province
Florida
ZIP/Postal Code
34677
Country
United States
Facility Name
Clinical Neuroscience Solutions, Inc
City
Orlando
State/Province
Florida
ZIP/Postal Code
32801
Country
United States
Facility Name
Omega Research Maitland, LLC
City
Orlando
State/Province
Florida
ZIP/Postal Code
32808
Country
United States
Facility Name
Innovation Medical Research Center, Inc
City
Palmetto Bay
State/Province
Florida
ZIP/Postal Code
33157
Country
United States
Facility Name
GCP, Global Clinical Professionals
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33702
Country
United States
Facility Name
Gateway (Ultrasound)
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33712
Country
United States
Facility Name
Partners Imaging Center
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Radiology Associates
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606
Country
United States
Facility Name
Center for Clinical Studies
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
AdventHealth Zephyrhills
City
Zephyrhills
State/Province
Florida
ZIP/Postal Code
33541
Country
United States
Facility Name
Florida Medical Clinic, LLC
City
Zephyrhills
State/Province
Florida
ZIP/Postal Code
33542
Country
United States
Facility Name
Digestive Healthcare of Georgia
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309
Country
United States
Facility Name
Piedmont Atlanta Hospital/Piedmont Transplant Institute
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309
Country
United States
Facility Name
Piedmont Atlanta Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309
Country
United States
Facility Name
Columbus Regional Research Institute
City
Columbus
State/Province
Georgia
ZIP/Postal Code
31904
Country
United States
Facility Name
WR-Mount Vernon Clinical Research, LLC
City
Sandy Springs
State/Province
Georgia
ZIP/Postal Code
30328
Country
United States
Facility Name
Tekton Research, Inc.
City
Snellville
State/Province
Georgia
ZIP/Postal Code
30078
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Investigators Research Group, LLC
City
Brownsburg
State/Province
Indiana
ZIP/Postal Code
46112
Country
United States
Facility Name
Hendricks Regional Health
City
Hendricks
State/Province
Indiana
ZIP/Postal Code
46122
Country
United States
Facility Name
Heartland Medical Research, Inc. (Administrative Only)
City
Clive
State/Province
Iowa
ZIP/Postal Code
50325
Country
United States
Facility Name
Iowa Digestive Disease Center
City
Clive
State/Province
Iowa
ZIP/Postal Code
50325
Country
United States
Facility Name
Iowa Radiology
City
Clive
State/Province
Iowa
ZIP/Postal Code
50325
Country
United States
Facility Name
MercyOne Des Moines Medical Center (Mercy Medical Center)
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50314
Country
United States
Facility Name
University of Iowa Hospitals and Clinics
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
University of Iowa Magnetic Resonance Research Facility
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Kansas Medical Clinic PA
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Alliance for Multispecialty Research, LLC
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67205-1138
Country
United States
Facility Name
Cypress Interventional
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67226
Country
United States
Facility Name
Centex Studies, Inc.
City
Lake Charles
State/Province
Louisiana
ZIP/Postal Code
70601
Country
United States
Facility Name
Lake Charles Memorial Hospital
City
Lake Charles
State/Province
Louisiana
ZIP/Postal Code
70601
Country
United States
Facility Name
Metropolitan Gastroenterology Associates
City
Marrero
State/Province
Louisiana
ZIP/Postal Code
70072
Country
United States
Facility Name
Tandem Clinical Research GI, LLC
City
Marrero
State/Province
Louisiana
ZIP/Postal Code
70072
Country
United States
Facility Name
Ochsner Clinic Foundation
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Louisiana Research Center, LLC
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71105
Country
United States
Facility Name
Gastro Health Research
City
Catonsville
State/Province
Maryland
ZIP/Postal Code
21228
Country
United States
Facility Name
Gastro Center of Maryland
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21045
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Michigan Clinical Research Unit (MCRU)
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
University of Michigan
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Henry Ford Health System
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Aa Mrc Llc
City
Flint
State/Province
Michigan
ZIP/Postal Code
48504
Country
United States
Facility Name
Mercy Health
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Facility Name
M1 Imaging Center
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49505
Country
United States
Facility Name
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
City
Wyoming
State/Province
Michigan
ZIP/Postal Code
49519
Country
United States
Facility Name
Mayo Clinic
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Jefferson City Medical Group, P.C.
City
Jefferson City
State/Province
Missouri
ZIP/Postal Code
65109
Country
United States
Facility Name
Desert Radiology
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89104
Country
United States
Facility Name
Machuca Family Medicine
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89104
Country
United States
Facility Name
The Machuca Foundation, Inc.
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89104
Country
United States
Facility Name
Sierra Clinical Research
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89106
Country
United States
Facility Name
Las Vegas Medical Research
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89113
Country
United States
Facility Name
Pueblo Medical Imaging
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89118
Country
United States
Facility Name
Digestive Healthcare Associates
City
Hillsborough
State/Province
New Jersey
ZIP/Postal Code
08844
Country
United States
Facility Name
University Radiology
City
Hillsborough
State/Province
New Jersey
ZIP/Postal Code
08844
Country
United States
Facility Name
Amici Clinical Research
City
Raritan
State/Province
New Jersey
ZIP/Postal Code
08869
Country
United States
Facility Name
Northwell Health Center for Liver Diseases
City
Manhasset
State/Province
New York
ZIP/Postal Code
11030
Country
United States
Facility Name
Icahn School of Medicine at Mount Sinai Beth Israel
City
New York
State/Province
New York
ZIP/Postal Code
10003
Country
United States
Facility Name
Mount Sinai Downtown Union Square
City
New York
State/Province
New York
ZIP/Postal Code
10003
Country
United States
Facility Name
Hess Building- CMS
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
Icahn School of Medicine at Mount Sinai/The Mount Sinai Hospital
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
The Mount Sinai Hospital: Department of Pharmacy
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
M3-Wake Research, Inc.
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
26712
Country
United States
Facility Name
Gastroenterology Associates of the Piedmont, PA
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Novant Health Medical Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
PMG Research of Winston-Salem, LLC
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Paramount Medical Research & Consulting, LLC
City
Middleburg Heights
State/Province
Ohio
ZIP/Postal Code
44130
Country
United States
Facility Name
Comprehensive Diagnostic Imaging
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Digestive Disease Specialists, Inc. Endoscopy Lab
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Digestive Disease Specialists, Inc.
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Oklahoma Spine Hospital
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73134
Country
United States
Facility Name
Thomas Jefferson University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
UPMC - Center for Liver Diseases at the Thomas E. Starzl Institute
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
UPMC - Center for Liver Diseases in the Digestive Disorders Clinic
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
UPMC - Translational Research Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
UPMC Presbyterian Shadyside; Presbyterian Campus Pharmacy
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
UPMC
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
University Gastroenterology
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02905
Country
United States
Facility Name
Roger Williams Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02908
Country
United States
Facility Name
Medical University of South Carolina
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
MUSC- Ashley River Tower
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Chattanooga Imaging Center
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37421
Country
United States
Facility Name
WR-Clinsearch, LLC
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37421
Country
United States
Facility Name
Quality Medical Research, PLLC
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37211
Country
United States
Facility Name
Vanderbilt University Medical Center - GI Research Office
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37212-1610
Country
United States
Facility Name
Vanderbilt Hepatology and Liver Transplant
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37212
Country
United States
Facility Name
Vanderbilt University Medical Center - Digestive Disease Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Vanderbilt University Medical Center - Heart Station
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Vanderbilt University Medical Center - Interventional Radiology
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Texas Center for Interventional Surgery (Liver Biopsy Facility)
City
Addison
State/Province
Texas
ZIP/Postal Code
75001
Country
United States
Facility Name
Texas Clinical Research Institute
City
Arlington
State/Province
Texas
ZIP/Postal Code
76012
Country
United States
Facility Name
Methodist Dallas Medical Center (Liver Biopsy)
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Facility Name
Methodist Dallas Medical Center (MRI-PDFF)
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Facility Name
The Liver Institute at Methodist Dallas Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Facility Name
Touchstone Imaging
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Center For Diagnostic Imaging
City
DeSoto
State/Province
Texas
ZIP/Postal Code
75115
Country
United States
Facility Name
GI Alliance
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Therapeutic Concepts, PA
City
Houston
State/Province
Texas
ZIP/Postal Code
77004
Country
United States
Facility Name
Centex Studies, Inc.
City
Houston
State/Province
Texas
ZIP/Postal Code
77058
Country
United States
Facility Name
Biopharma Informatic, LLC
City
Houston
State/Province
Texas
ZIP/Postal Code
77084
Country
United States
Facility Name
Premier Vein and Vascular
City
Houston
State/Province
Texas
ZIP/Postal Code
77084
Country
United States
Facility Name
Centex Studies, Inc
City
McAllen
State/Province
Texas
ZIP/Postal Code
78504
Country
United States
Facility Name
HCA Houston Healthcare Pearland
City
Pearland
State/Province
Texas
ZIP/Postal Code
77584
Country
United States
Facility Name
American Research Corporation at the Texas Liver Institute
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78215
Country
United States
Facility Name
Clinical Trials of Texas, Inc.
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Diabetes and Glandular Disease Clinic, P.A.
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Reddy Cardiac Wellness
City
Sugar Land
State/Province
Texas
ZIP/Postal Code
77479
Country
United States
Facility Name
Impact Research Institute
City
Waco
State/Province
Texas
ZIP/Postal Code
76710
Country
United States
Facility Name
Gastro Health Research
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Facility Name
Manassas Clinical Research Center
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20110
Country
United States
Facility Name
Digestive and Liver Disease Specialists
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
Sentara Leigh Hospital
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
McGuire VA Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
VCU Medical Center Investigational Drug Service
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298-5051
Country
United States
Facility Name
Virginia Commonwealth University
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Facility Name
Virginia Gastroenterology Clinical Research
City
Suffolk
State/Province
Virginia
ZIP/Postal Code
23435
Country
United States
Facility Name
Harborview Medical Center Investigational Drug Services
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
Harborview Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
Seattle Radiology
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
Liver Institute Northwest
City
Seattle
State/Province
Washington
ZIP/Postal Code
98105
Country
United States
Facility Name
Swedish Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98122
Country
United States
Facility Name
University of Washington Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
MHAT Dr. Tota Venkova AD
City
Gabrovo
ZIP/Postal Code
5300
Country
Bulgaria
Facility Name
MHAT Medline Clinic AD
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
Facility Name
Acibadem City Clinic MHAT Tokuda EAD
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Facility Name
DCC Alexandrovska EOOD
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
UMHAT Alexandrovska EAD
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
UMHAT Sv. Ivan Rilski EAD
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
UMHAT Sofiamed OOD
City
Sofia
ZIP/Postal Code
1797
Country
Bulgaria
Facility Name
MC New Rehabilitation Center EOOD
City
Stara Zagora
ZIP/Postal Code
6001
Country
Bulgaria
Facility Name
DCC Mladost-M Varna OOD
City
Varna
ZIP/Postal Code
9020
Country
Bulgaria
Facility Name
MC VIP Clinic OOD
City
Varna
ZIP/Postal Code
9020
Country
Bulgaria
Facility Name
University of Calgary - Heritage Medical Research Clinic (HMRC)
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
Facility Name
University of Alberta Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Facility Name
University of Alberta
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2X8
Country
Canada
Facility Name
Gordon and Leslie Diamond Health Care Centre
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1M9
Country
Canada
Facility Name
(G.I.R.I.) GI Research Institute
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z 2K5
Country
Canada
Facility Name
Nova Scotia Health Authority QEII (Queen Elizabeth II) Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 1V7
Country
Canada
Facility Name
Manna Research (London)
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 2C2
Country
Canada
Facility Name
Toronto Liver Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6H 3M1
Country
Canada
Facility Name
Resonance Magnetique du Saguenay-Lac-Saint-Jean
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 4J1
Country
Canada
Facility Name
Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 5H6
Country
Canada
Facility Name
Ecogene-21
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 7K9
Country
Canada
Facility Name
McGill University Health Centre (MUHC)
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4A 3J1
Country
Canada
Facility Name
Philips Radiation Oncology
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4A 3J1
Country
Canada
Facility Name
Research Institute of the MUHC
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4A 3J1
Country
Canada
Facility Name
Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM)
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H2X 0A9
Country
Canada
Facility Name
Diex Recherche Quebec Inc.
City
Quebec
ZIP/Postal Code
G1V 4T3
Country
Canada
Facility Name
Beijing Friendship Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100050
Country
China
Facility Name
The First Affiliated Hospital, Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Facility Name
The Third Hospital of Hebei Medical University
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050051
Country
China
Facility Name
Hunan Provincial People's Hospital
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410005
Country
China
Facility Name
The First Bethune Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Facility Name
General Hospital of Ningxia Medical University
City
Yinchuan
State/Province
Ningxia
ZIP/Postal Code
750004
Country
China
Facility Name
Qingdao Central Hospital
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266042
Country
China
Facility Name
The Affiliated Hospital of Hangzhou Normal University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
The First Affiliated Hospital of Wenzhou Medical University
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China
Facility Name
Peking University People's Hospital
City
Beijing
ZIP/Postal Code
100044
Country
China
Facility Name
Beijing YouAn Hosptial,Capital Medical University
City
Beijing
ZIP/Postal Code
100069
Country
China
Facility Name
Beijing Tsinghua Changgung Hospital
City
Beijing
ZIP/Postal Code
102218
Country
China
Facility Name
Tianjin Third Central Hospital
City
Tianjin
ZIP/Postal Code
300170
Country
China
Facility Name
Tianjin Second People's Hospital
City
Tianjin
ZIP/Postal Code
300192
Country
China
Facility Name
Queen Mary Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Prince of Wales Hospital
City
Shatin
Country
Hong Kong
Facility Name
Alice Ho Miu Ling Nethersole Hospital
City
Tai Po
Country
Hong Kong
Facility Name
Surat Institute of Digestive Sciences
City
Surat
State/Province
Gujarat
ZIP/Postal Code
395002
Country
India
Facility Name
Gujarat Hospital - Gastro and Vascular Centre
City
Surat
State/Province
Gujarat
ZIP/Postal Code
395009
Country
India
Facility Name
Global Hospital - Super Speciality & Transplant Centre
City
Mumbai
State/Province
Maharashtra
ZIP/Postal Code
400012
Country
India
Facility Name
Max Smart Super Speciality Hospital
City
Saket
State/Province
NEW Delhi
ZIP/Postal Code
110017
Country
India
Facility Name
S.M.S. Medical College & Hospital
City
Jaipur
State/Province
Rajasthan
ZIP/Postal Code
302004
Country
India
Facility Name
Institute of Post Graduate Medical Education and Research & SSKM Hospital
City
Kolkata
State/Province
WEST Bengal
ZIP/Postal Code
700020
Country
India
Facility Name
Medanta - The Medicity
City
Gurugram
ZIP/Postal Code
122001
Country
India
Facility Name
Institute of Liver and Biliary Sciences (ILBS)
City
New Delhi
ZIP/Postal Code
110 070
Country
India
Facility Name
All India Institute of Medical Sciences (AIIMS)
City
New Delhi
ZIP/Postal Code
110029
Country
India
Facility Name
Aichi Medical University Hospital
City
Nagakute
State/Province
Aichi
ZIP/Postal Code
480-1195
Country
Japan
Facility Name
Ehime University Hospital
City
Toon
State/Province
Ehime
ZIP/Postal Code
791-0295
Country
Japan
Facility Name
Ogaki Municipal Hospital
City
Ogaki
State/Province
Gifu
ZIP/Postal Code
503-8502
Country
Japan
Facility Name
Tokyo Medical University Ibaraki Medical Center
City
Inashiki-gun
State/Province
Ibaraki
ZIP/Postal Code
300-0395
Country
Japan
Facility Name
Kagawa Prefectural Central Hospital
City
Takamatsu
State/Province
Kagawa
ZIP/Postal Code
760-8557
Country
Japan
Facility Name
Yokohama City University Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
236-0004
Country
Japan
Facility Name
Shinshu University Hospital
City
Matsumoto
State/Province
Nagano
ZIP/Postal Code
3908621
Country
Japan
Facility Name
National Hospital Organization Nagasaki Medical Center
City
Ohmura
State/Province
Nagasaki
ZIP/Postal Code
856-8562
Country
Japan
Facility Name
Osaka Rosai Hospital
City
Sakai
State/Province
Osaka
ZIP/Postal Code
591-8025
Country
Japan
Facility Name
Saiseikai Suita Hospital
City
Suita
State/Province
Osaka
ZIP/Postal Code
564-0013
Country
Japan
Facility Name
Juntendo University Shizuoka Hospital
City
Izunokuni
State/Province
Shizuoka
ZIP/Postal Code
410-2295
Country
Japan
Facility Name
Chiba University Hospital
City
Chiba
ZIP/Postal Code
260-8677
Country
Japan
Facility Name
Fukui-Ken Saiseikai Hospital
City
Fukui
ZIP/Postal Code
918-8503
Country
Japan
Facility Name
Gifu Municipal Hospital
City
Gifu
ZIP/Postal Code
500-8513
Country
Japan
Facility Name
Kagoshima University Hospital
City
Kagoshima
ZIP/Postal Code
890-8520
Country
Japan
Facility Name
University Hospital, Kyoto Prefectural University of Medicine
City
Kyoto
ZIP/Postal Code
602-8566
Country
Japan
Facility Name
Miyazaki Medical Center Hospital
City
Miyazaki
ZIP/Postal Code
880-0003
Country
Japan
Facility Name
Saga University Hospital
City
Saga
ZIP/Postal Code
849-8501
Country
Japan
Facility Name
Yamagata University Hospital
City
Yamagata
ZIP/Postal Code
990-9585
Country
Japan
Facility Name
SMG-SNU Boramae Medical Center
City
Dongjak-gu
State/Province
Seoul
ZIP/Postal Code
07061
Country
Korea, Republic of
Facility Name
Pusan National University Hospital
City
Busan
ZIP/Postal Code
49241
Country
Korea, Republic of
Facility Name
Kyungpook National University Hospital
City
Daegu
ZIP/Postal Code
41944
Country
Korea, Republic of
Facility Name
Yeungnam University Hospital
City
Daegu
ZIP/Postal Code
42415
Country
Korea, Republic of
Facility Name
Severance Hospital Yonsei University Health System
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Szpital Zakonu Bonifratrow
City
Katowice
ZIP/Postal Code
40-211
Country
Poland
Facility Name
NZOZ Vita Longa Sp. z o.o.
City
Katowice
ZIP/Postal Code
40-748
Country
Poland
Facility Name
Uniwersyteckie Centrum Kliniczne im. prof. K. Gibinskiego Slaskiego Uniwersytetu Medycznego
City
Katowice
ZIP/Postal Code
40-752
Country
Poland
Facility Name
Orthos Szpital Wielospecjalistyczny Sp. z o.o. (Liver Biopsy)
City
Komorowice
ZIP/Postal Code
52-229
Country
Poland
Facility Name
SPZOZ Szpital Uniwersytecki w Krakowie
City
Krakow
ZIP/Postal Code
30-688
Country
Poland
Facility Name
Szpital Zakonu Bonifratrów św. Jana Grandego w Krakowie sp. z o.o. (Liver Biopsy)
City
Krakow
ZIP/Postal Code
31-061
Country
Poland
Facility Name
Krakowskie Centrum Medyczne
City
Krakow
ZIP/Postal Code
31-501
Country
Poland
Facility Name
Wojewodzki Specjalistyczny Szpital im. Dr. Wl. Bieganskiego w Lodzi
City
Lodz
ZIP/Postal Code
91-347
Country
Poland
Facility Name
ID Clinic
City
Myslowice
ZIP/Postal Code
41-400
Country
Poland
Facility Name
WIP Warsaw IBD Point Profesor Kierkus
City
Warszawa
ZIP/Postal Code
00-728
Country
Poland
Facility Name
Futuremeds Sp. z o.o.
City
Wroclaw
ZIP/Postal Code
50-088
Country
Poland
Facility Name
ETG Zamo??
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
ETG Zamosc
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
Clinical Research Puerto Rico
City
San Juan
ZIP/Postal Code
00909
Country
Puerto Rico
Facility Name
Latin Clinical Trial Center
City
San Juan
ZIP/Postal Code
00909
Country
Puerto Rico
Facility Name
GCM Medical Group PSC
City
San Juan
ZIP/Postal Code
00917
Country
Puerto Rico
Facility Name
FDI Clinical Research
City
San Juan
ZIP/Postal Code
00927
Country
Puerto Rico
Facility Name
Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica
City
Banska Bystrica
ZIP/Postal Code
974 01
Country
Slovakia
Facility Name
SUMMIT CLINICAL RESEARCH, s.r.o.
City
Bratislava - Mestska Cast Nove Mesto
ZIP/Postal Code
831 01
Country
Slovakia
Facility Name
Lama Medical Care s.r.o.
City
Bratislava - Mestska Cast Ruzinov
ZIP/Postal Code
831 04
Country
Slovakia
Facility Name
Medispektrum, s.r.o
City
Bratislava
ZIP/Postal Code
851 01
Country
Slovakia
Facility Name
Univerzitna nemocnica L. Pasteura Kosice
City
Kosice - Mestska Cast Zapad
ZIP/Postal Code
040 11
Country
Slovakia
Facility Name
KM Management spol. s.r.o., Gastroenterologicke a hepatologicke centrum Nitra
City
Nitra
ZIP/Postal Code
949 01
Country
Slovakia
Facility Name
Fakultna nemocnica Nitra
City
Nitra
ZIP/Postal Code
950 01
Country
Slovakia
Facility Name
JAL, s.r.o.
City
Trnava
ZIP/Postal Code
917 01
Country
Slovakia
Facility Name
Changhua Christian Hospital
City
Changhua City
State/Province
Changhua County
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Ditmanson Medical Foundation Chia-Yi Christian Hospital
City
Chia-Yi
ZIP/Postal Code
600
Country
Taiwan
Facility Name
Kaohsiung Medical University Chung-Ho Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Facility Name
National Cheng Kung University (NCKU) Hospital
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
IPD Sharing URL
https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests
Citations:
PubMed Identifier
35354614
Citation
Amin NB, Darekar A, Anstee QM, Wong VW, Tacke F, Vourvahis M, Lee DS, Charlton M, Alkhouri N, Nakajima A, Yunis C. Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study. BMJ Open. 2022 Mar 30;12(3):e056159. doi: 10.1136/bmjopen-2021-056159.
Results Reference
derived
Links:
URL
https://pmiform.com/clinical-trial-info-request?StudyID=C2541013
Description
To obtain contact information for a study center near you, click here.

Learn more about this trial

Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)

We'll reach out to this number within 24 hrs