Metabolomics and Wound Healing in Diabetes
Diabetes Mellitus, Type 2, Infection
About this trial
This is an interventional health services research trial for Diabetes Mellitus, Type 2
Eligibility Criteria
Inclusion Criteria:
- are men or non-pregnant women, aged ≥ 40 years or ≤ 80 years
- have a history of foot ulcers for more than 1 month
- have a serum albumin level ≤ 4.0 or an ABI level ≤ 1
Exclusion Criteria:
- Have active malignancy
- Have acute gastrointestinal surgery
- are receiving dialysis
- have heart failure (NYHA Fc ≥ 3), liver cirrhosis (Child class > B), or myocardial infarction in the past 3 months,
- have wounds complicated with persistent osteomyelitis or Charcot deformity
- are receiving hydroxyurea or steroid treatment
- have alcohol abuse, any mental or physiological condition that may interfere with dietary intake, and those who are unable to follow orders or cooperate.
Sites / Locations
- Chang Gung Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
L-arginine supplements
nutritional supports
The enrolled subjects will then be randomized into two groups. Study Group: will take a supplementation pill containing 5 g L-arginine (0.5g/ pill, GNC, USA) All the food intake of the subjects during the 4 weeks of the study will be recorded and supervised by responsible dietitians.
The enrolled subjects will then be randomized into two groups. Control group: will take a supplementation pill containing 5 g whey protein (5g/ pack, Santosa,Taiwan). All the food intake of the subjects during the 4 weeks of the study will be recorded and supervised by responsible dietitians.