Metabotropic Glutamate Receptor-5 (mGlur5) Effects on Reward-Related fMRI-BOLD Activation in FHP and FHN

This is an interventional prevention trial for Familial Alcoholism Vulnerability Read More

Inclusion Criteria:

• Subjects will be first screened toxicologically for drugs of abuse (and for women of childbearing age, pregnancy) by urine testing, any positive test results in exclusion.
• Participants will be able to understand the procedures as judged by their ability to clearly repeat back to the PI or his designee correctly, the purpose and content of the planned research, and willingly agree to participate.

Exclusion Criteria:

1. a diagnosis of DSM-IV psychiatric disorder
2. report of psychotic disorder in a 1º relative, auditory or visual impairment that interferes with test-taking
3. prenatal exposure to alcohol plus currently meeting criteria for features of fetal alcohol syndrome
4. not speaking English fluently or being a non-native English speaker, or being educated in a primary language other than English > grade 1
5. mental retardation (Full Scale IQ<70)
6. traumatic brain injury with loss of consciousness > 30 minutes or concussion in last 30 days
7. presence or history of any medical/neurologic illness that may affect brain physiology (e.g., epilepsy, Multiple Sclerosis), including focal brain lesion seen on structural MRI (all structural scans are read by a licensed radiologist)
8. current pregnancy (all females will be tested with urine screens on the day of MRI);
9. All participants will receive a urine screen for the presence of marijuana, cocaine, opiates and a breath screen to detect the presence of alcohol
10. Inability to comprehend the consent form appropriately

11. Other specific fMRI exclusions include metal devices, clips or fragments in body (orbital x-ray performed if needed).

    • Individuals will be excluded who have taken, within the prior 14 days, the following strong inhibitors or inducers of CYP1A, CYP2C, and CYP3A and CYP3A4: iprofloxacin, enoxacin, fluvoxamine; gemfibrozil; fluconazole, fluvoxamine, ticlopidine; boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole; bupropion, fluoxetine, paroxetine, quinidine; avasimibe, carbamazepine, phenytoin, rifampin, and St. John's wort.
    • Individuals will also be excluded who have taken, within 14 days, the following moderate inhibitors and inducers of CYP3A: Amprenavir, aprepitant, atazanavir, ciprofloxacin, crizotinib, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fosamprenavir, imatinib, and verapamil; and bosentan, efavirenz, etravirine, modafinil, and nafcillin.