Methadone Effects on Zidovudine (ZDV, AZT) Disposition
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Methadone, Drug Interactions, Drug Therapy, Combination, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Zidovudine
Eligibility Criteria
Inclusion Criteria Patients must have: Documented HIV infection. CD4 count 100 - 500 cells/mm3. No active opportunistic infection or wasting syndrome. Opiate addiction or prior enrollment in a methadone treatment program (methadone recipients only). Admission to General Clinical Research Center at Yale-New Haven Hospital for clonidine detoxification (methadone recipients only). Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Inadequate IV access. Benzodiazepine abuse. Concurrent Medication: Excluded: Amiodarone. Anesthetics, general. Azithromycin. Barbiturates. Carbamazepine. Cimetidine. Ciprofloxacin. Clarithromycin. Dexamethasone. Disulfiram. Erythromycin. Fluoroquinolones. Fluoxetine. Gestodene. Hydrochlorothiazide. Hypoglycemics, oral. Isoniazid. Itraconazole. Ketoconazole. Levomepromazine. MAO inhibitors. Methoxsalen. Nafcillin. Narcotic analgesics. Naringenin. Norethindrone. Omeprazole. Pentazocine. Phenothiazines. Phenytoin. Quinidine. Ranitidine. Rifabutin. Rifampin. Sedative Hypnotics. Sulfaphenazole. Tranquilizers (except at discretion of investigator and protocol chair). Tricyclic antidepressants. Troleandomycin. Warfarin. Prior Medication: Excluded within 4 weeks prior to study entry: Rifampin or its derivatives. Phenytoin. Barbiturates. Cimetidine. Other drugs known to induce or inhibit hepatic microsomal enzymes. Excluded within 14 days prior to study entry: Any other experimental drug. Drugs with known nephrotoxic potential. Excluded within 72 hours prior to study entry: Amiodarone. Anesthetics, general. Azithromycin. Carbamazepine. Ciprofloxacin. Clarithromycin. Dexamethasone. Disulfiram. Erythromycin. Fluoroquinolones. Fluoxetine. Gestodene. Hydrochlorothiazide. Hypoglycemics, oral. Isoniazid. Itraconazole. Ketoconazole. Levomepromazine. MAO inhibitors. Methoxsalen. Nafcillin. Narcotic analgesics. Naringenin. Norethindrone. Omeprazole. Pentazocine. Phenothiazines. Quinidine. Ranitidine. Rifabutin. Sedative Hypnotics. Sulfaphenazole. Tranquilizers (except at discretion of investigator and protocol chair). Tricyclic antidepressants. Troleandomycin. Warfarin. Continued active drug or alcohol abuse or dependence that would decrease the probability of study completion.
Sites / Locations
- Yale Univ / New Haven