MExiletine Versus Lamotrigine in Non-Dystrophic Myotonias (MEND)
Non-Dystrophic Myotonia
About this trial
This is an interventional treatment trial for Non-Dystrophic Myotonia
Eligibility Criteria
Inclusion Criteria:
- adults (≥ 18years),
- genetically confirmed non-dystrophic myotonia (NDM),
- presence of symptomatic myotonia as reported by the participant.
Exclusion Criteria:
- concomitant medical conditions that would preclude the use of mexiletine or lamotrigine,
- evidence of severe kidney disease or severe liver impairment [estimated glomerular filtration rate (eGFR) as calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Creatinine Equation <60ml/min/1.73m2],
- pregnant or breastfeeding women,
- participation in other treatment studies <30days before enrolment.
Sites / Locations
- University College London HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Lamotrigine
Mexiletine
When on the lamotrigine treatment arm, the participant will commence at lamotrigine 25mg (milligram) daily for two weeks; then increase to 25mg twice daily for two weeks; then increase to 50mg daily for one week; then increase to 100mg in the morning, 50mg at midday and 50mg at night for one week; then increase to 100mg in the morning, 50mg at midday and 100mg at night for two weeks.
When on the mexiletine treatment arm, the participant will commence at mexiletine 100mg daily for two weeks; then increase to 200mg daily for two weeks; then increase to 200mg twice daily for one week; then increase to 200mg three times a day for one week; then remain on 200mg three times a day for two weeks.