Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia

Inclusion Criteria: Patients either non-neutropenic with absolute neutrophil counts >= 500 cells/mm3 or neutropenic with absolute neutrophil counts < 500 cells/mm3 must have: Candidemia or invasive candidiasis, Confirmation and typical clinical signs and symptoms by fungal culture and/or histology, Positive culture obtained no more than four days prior to the first dose of study medication. Exclusion Criteria: Patient is pregnant or nursing Patients with evidence of liver disease as defined by: a) SGOT/AST or SGPT/ALT > 10 times the upper limit of normal (ULN); or b) Total bilirubin > 5 times ULN. Patients whose sole diagnosis is oropharyngeal and/or esophageal candidiasis and/or with positive cultures of urine specimens, sputum specimens, bronchoalveolar-lavage specimens or samples from indwelling drains. Patients who have received prophylactic/empiric therapy with azoles or conventional amphotericin B for more than three days within one week prior to enrollment. Neutropenic patients, however, may have received prophylactic azoles without time restrictions.