Microbiota as Potential Target for Food Allergy (MATFA)

Food allergy (FA) derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for enteric microflora in oral tolerance development. An altered composition of intestinal microflora results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. These findings support the concept that specific beneficial bacteria from human intestinal microflora, designated probiotics, could restore intestinal microflora homeostasis and prevent or treat FA.

Composition and function gut microbiota comparing cow milk allergy Italian and cow milk allergy children of other countries

Composition and function gut microbiota comparing healthy Italian and healthy children of other countries

Inclusion Criteria: children with cow's milk allergy age 6-12 months Exclusion Criteria: concomitant chronic systemic diseases congenital cardiac defects active tuberculosis autoimmune diseases immunodeficiency chronic inflammatory bowel diseases celiac disease, cystic fibrosis metabolic diseases malignancy chronic pulmonary diseases malformations of the gastrointestinal tract suspected eosinophilic esophagitis or eosinophilic enterocolitis suspected food-protein-induced enterocolitis syndrome.