Microglia Activation in Schizophrenia
Schizophrenia
About this trial
This is an interventional diagnostic trial for Schizophrenia focused on measuring schizophrenia, microglia, PET
Eligibility Criteria
Inclusion Criteria: Schizophrenia according to DSM-IV criteria confirmed by a diagnostic interview (CASH, only for patients) within the first 5 years after initial diagnosis Male and Females Good physical or mental (controls) Health which will be evaluated with medical history, a physical examination and screening laboratory tests (see appendix 1). Age between 18 and 40 years (10 patients and 10 controls) Mini Mental State score >27 . Written informed consent of the subject. Hb must be >8 mmol \ litre at the time of the screening. Exclusion Criteria: Previous neurotrauma with loss of consciousness Any clinical significant abnormality of any clinical laboratory test, including drug screening. Any subject who has received any investigational medication within 30 days prior to the start of this study, or who is scheduled to receive an investigational drug. any other major current psychiatric diagnosis on axis-1 of DSM-IV (patients) History of psychiatric or neurological illness (controls) History of psychiatric or neurological illness in first-degree relatives (controls) History of alcohol and/or drug abuse (DSM-IV criteria) Blood donation within 3 months before the scan day Claustrophobia Metal objects in or around the body (braces, pacemaker, metal fragments); Pregnancy
Sites / Locations
- VU University Medical Center