Mild TBI Assessment & Rehabilitation (MTAR)
Brain Injuries, Traumatic
About this trial
This is an interventional treatment trial for Brain Injuries, Traumatic focused on measuring Rehabilitation, Functional Magnetic Resonance Imaging
Eligibility Criteria
Inclusion Criteria:
For TBI-positive veteran participants, to be randomized to either GOALS or TAU:
- Ages 18+
- A history of mild TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument)
- Chronic, stable phase of recovery (>6 months from last post-concussive event)
- Report of residual cognitive difficulties (1 moderate or severe cognitive symptom(s) on the Neurobehavioral Symptom Inventory (NSI)) that interfere(s) with daily function
- Able and willing to commit to participate in training and assessments
- If on psychoactive medications, must be stable on medications (> 30 days)
For the TBI-negative healthy veteran control group:
- Ages 18+
- No history of any (mild to severe) TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument)
- Able and willing to commit to participate in assessments
- If on psychoactive medications, must be stable on medications (> 30 days)
Exclusion Criteria:
For the TBI-positive veteran participants, to be randomized to either GOALS or TAU:
- A history of moderate or severe TBI
- Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g., contraindications to MRI)
- Ongoing illicit drug or alcohol abuse (AUDIT>8)
- Psychosis
- Severe depression, anxiety or PTSD that precludes participation in research activities
- Poor English comprehension
- Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD
- There will be no restriction in regard to gender, race and socioeconomic status
For the TBI-negative healthy veteran control group:
- A history of any mild, moderate, or severe TBI
- Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g. contraindications to MRI)
- Ongoing illicit drug or alcohol abuse (AUDIT>8)
- Psychosis
- Severe depression, anxiety or PTSD that precludes participation in research activities
- Poor English comprehension
- Eligible participants may have other co-morbid stable neuropscyhiatric disorders, including depression and PTSD.
- There will be no restriction in regard to gender, race and socioeconomic status
Sites / Locations
- San Francisco VA Medical Center, San Francisco, CA
- University of California, San FranciscoRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
No Intervention
Veteran Mild TBI Group - GOALS Intervention
Veteran Mild TBI - Treatment as Usual
Veteran Non TBI - No Treatment
Veterans ages 18+ with chronic mild TBI, to undergo GOALS cognitive training as an intervention.
Veterans ages 18+ with chronic mild TBI, matched by demographic and clinical criteria to the GOALS group, to receive the standard clinical care.
Veterans ages 18+ with no history of TBI, to undergo Neuropsychologic evaluation and MR Imaging with no intervention.