Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum
Gynecologic Disease, Neuromuscular Blockade
About this trial
This is an interventional other trial for Gynecologic Disease focused on measuring deep neuromuscular block, low pressure pneumoperitoneum, laparoscopic gynaecological surgery
Eligibility Criteria
Inclusion Criteria: Age more than 18 years old ASA I or II schedule to undergo laparoscopic gynaecological surgery (laparoscopic hysterectomy and laparoscopic ovarian cystectomy in Hospital Universiti Sains Malaysia , Kubang Kerian, Kelantan Exclusion Criteria: Allergy to study drugs (rocuronium, suggamadex) Serious cardiac and respiratory disease (reactive airway disease, upper respiratory tract infection) Neurological or neuromuscular disease (epilepsy, family history and history of malignant hyperthermia etc.) Pregnancy Morbid obesity BMI>35
Sites / Locations
- University of Science Malaysia Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
deep neuromuscular block group
moderate neuromuscular block group
Group 1 (Induction with Rocuronium 0.6mg/kg + maintenance with intravenous Rocuronium rocuronium 8-12mcg/kg/minute (0.48-0.72 mg/kg/hour maintain PTC 0-1(deep block). (Study Group) intraoperatively
Group 2 (Induction with intravenous Rocuronium 0.6mg/kg + maintenance with intermittent intravenous Rocuronium 0.2mg/kg bolus. maintain PTC >1, TOF 0-2). Moderate block. (Control Group) intraoperatively