MOdularity for SEnsory Motor Control (MOSE)

This is an interventional treatment trial for Stroke, Ischemic focused on measuring Muscle Synergies, MRI, Virtual Reality, Robotics Read More

Inclusion Criteria:

• diagnosis of first stroke;
• a score between 1 and 3 (included) at the upper limb sub-item on the Italian version of the National Institute of Health stroke scale (IT - NIHSS) (Pezzella et al., 2009)
• a score higher than 6 out of 66 on the Fugl - Meyer upper extremity (F-M UE) scale (Fugl-Meyer et al., 1975).

Exclusion Criteria:

• the presence of a moderate cognitive decline defined as a Mini Mental State Examination (Folstein et al., 1975) score < 20/30 points;
• the finding of severe verbal comprehension deficit defined as a number of errors > 13 (Tau Points < 58/78) on the Token Test (Huber et al., 1984);
• evidence of apraxia and visuospatial neglect interfering with upper arm movements and manipulation of simple objects in all the directions within the visual field, as assessed through neurological examination;
• report in the patient's clinical history or evidence from the neurological examination of behavioural disturbances (i.e. delusions, aggressiveness and severe apathy/depression) that could affect compliance with the rehabilitation programs;
• non stabilised fractures;
• diagnosis of depression/delusion;
• associated traumatic brain injury;
• drug resistant epilepsy;
• evidence of ideomotor apraxia;
• evidence of visuospatial neglect;
• severe impairment of verbal comprehension defined as a score higher than 13 errors on Token test (i.e. score<58 out of 78 Tau points).