Modulating Neuropathic Pain With Transcranial Direct Current Stimulation
Pain, Neuropathic, Complex Regional Pain Syndromes, Phantom Limb Pain
About this trial
This is an interventional treatment trial for Pain, Neuropathic focused on measuring neuroplasticity, rehabilitation, transcranial direct current stimulation
Eligibility Criteria
Inclusion Criteria:
- At least 18 years of age
- Have chronic (>12 months) neuropathic pain, including but not limited to complex regional pain syndrome, phantom limb pain, or pain of neurogenic origin following spinal cord injury
Exclusion Criteria:
- History of seizures or epilepsy
- Addition or change in the dosage of drugs now to interfere with pain within 1 month of enrollment
- Untreated depression
- History of head injury with loss of consciousness, severe alcohol or drug abuse, or psychiatric illness
- Positive pregnancy test or being of childbearing age and not using appropriate contraception
- Presence of ferromagnetic material in the cranium except in the mouth, including metal fragments from occupational exposure, and surgical clips in or near the brain
Sites / Locations
- University of Kentucky at Cardinal Hill Rehabilitation Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
tDCS of DLPFC
tDCS of M1
Sham tDCS
Subjects will receive 20 minutes of active transcranial direct current stimulation at 2mA applied to the left dorsolateral prefrontal cortex (DLPFC). Subjects will undergo stimulation once a day for 10 consecutive weekdays.
Subjects will receive 20 minutes of active transcranial direct current stimulation at 2mA applied to the left primary motor cortex (M1). Subjects will undergo stimulation once a day for 10 consecutive weekdays.
Subjects will receive 20 minutes of sham transcranial direct current stimulation. Subjects will undergo stimulation once a day for 10 consecutive weekdays.