Modulation of Benzene Metabolism by Exposure to Environment
Primary Purpose
Lung Diseases, Cancer
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Controlled Exposure to Environmental Contaminant
Sponsored by
About this trial
This is an interventional trial for Lung Diseases focused on measuring Benzene, Air pollution
Eligibility Criteria
Sites / Locations
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00041860
First Posted
July 18, 2002
Last Updated
June 23, 2005
Sponsor
National Institute of Environmental Health Sciences (NIEHS)
1. Study Identification
Unique Protocol Identification Number
NCT00041860
Brief Title
Modulation of Benzene Metabolism by Exposure to Environment
Study Type
Interventional
2. Study Status
Record Verification Date
July 2002
Overall Recruitment Status
Completed
Study Start Date
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Primary Completion Date
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Study Completion Date
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3. Sponsor/Collaborators
Name of the Sponsor
National Institute of Environmental Health Sciences (NIEHS)
4. Oversight
5. Study Description
Brief Summary
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment, such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages. To do so breath, urine, and blood samples prior to, during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured.
Detailed Description
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment, such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages. To do so breath, urine, and blood samples prior to, during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured. The exposures take place in the Controlled Environmental Facility operated by the Environmental and Occupational Health Sciences Institute (EOHSI). This allows us to control the exact benzene air level and to use benzene containing 13C, a stable (non-radioactive) form of carbon, one of the atoms that make up benzene. Isotopes are different forms of the same atom. Using 13C will allow us to tell the difference between the benzene and the compounds it changes to in the body that come from our experiment compared to what is present in your body from other sources. In addition to just benzene exposure on some days the subject is also be exposed to methyl tertiary butyl ether (MTBE), another component of gasoline, to take an iron supplement pill and/or to take vitamins C and E pills. How benzene is metabolized or changed in the body will be compared for these differences to better understand how the body deals with benzene.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lung Diseases, Cancer
Keywords
Benzene, Air pollution
7. Study Design
Study Phase
Not Applicable
8. Arms, Groups, and Interventions
Intervention Type
Procedure
Intervention Name(s)
Controlled Exposure to Environmental Contaminant
10. Eligibility
12. IPD Sharing Statement
Learn more about this trial
Modulation of Benzene Metabolism by Exposure to Environment
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