Modulation of Repetitive Transcranial Magnetic Stimulation on Hippocampal Neurogenesis and Functional Network in Patients With Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring first episode schizophrenia, rTMS, hippocampal neurogenesis, MRS, cognitive function
Eligibility Criteria
- Early schizophrenia group:
Inclusion Criteria:
- The Structured Interview for Prodromal Symptoms (SIPS) was employed.
- Meet the diagnostic criteria of Diagnostic and Statistical Manual Diploma in Social Medicine(DSM-V) schizophrenia or schizophreniform psychosis.
- 18-50years of age,right-handed,normal vision or corrected vision, Han nationality.
- Disease course less than 5 years.
- Written informed consent
Observation group: First-episode, In addition to criteria1-3,5,antipsychotics naïve,or antipsychotics withdrawal for more than 3 months.
Intervention group:In addition to criteria 1-6,currently under medication and medically stable for at least 1 month(PANSS score fluctuation<10%);continue the original antipsychotics for at least 1 months after recruitment,with consent of the patients,their psychiatrists and family members.
Exclusion criteria:
Current or past neurological illness,severe physical illness,substance abuse or addiction,alcohol dependence,mental retardation,pregnancy or lactation,extreme agitation, stupor, negative suicide,or those who can not cooperate.A history of MECT within 6 months,or those with contraindications to MRI,rTMS.Medically unstable for at least 1 month (PANSS score fluctuation>10%)
- Healthy controls:
Inclusion Criteria:
- The Structured Interview for Prodromal Symptoms (SIPS) was employed
- Matched to the early schizophrenia group in terms of age,sex ratio,handedness,and estimated premorbid IQ
- normal vision or corrected vision, Han nationality
- Written informed consent
Exclusion Criteria:
History of psychiatric disease in the subjects themselves or a family history of mental disorder in their first-degree relatives,neurological illness,severe physical illness,substance abuse or alcohol dependence,mental retardation.
Sites / Locations
- Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Sham Comparator
Sham Comparator
No Intervention
rTMS targeting the right DLPFC
rTMS targeting the left LPC
Observation group
60 patients will be randomly allocated into this group,half of them will receive iTBS on the right DLPFC,while the other half will receive sham stimulation.
60 patients will be randomly allocated into this group,half of them will receive iTBS on left LPC,while the other half will receive sham stimulation.
To investigate the abnormalities of hippocampal neurogenesis in patients with early schizophrenia(n=30) compared to healthy controls(n=30)