Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol For Chronic Subdural Hematoma
Conscious Sedation
About this trial
This is an interventional treatment trial for Conscious Sedation
Eligibility Criteria
Inclusion Criteria:
- Patient acceptance.
- Both sex.
- Age (50-80) years old.
- Patient with Body Mass Index (BMI) (25-30kg/m²).
- American Society of Anesthesiologist (ASA) II / III
- patient scheduled to burr-hole surgery for chronic subdural hematoma evacuation under MAC.
Exclusion Criteria:
- Patient with difficult airway (mallapati III,IV).
- Altered mental status (psychiatric and anexity disorder).
- Post-traumatic stress disorders.
- History of allergy to study drugs.
- Patient on sedative or hypnotic medication.
- Patients with on painkiller.
- Patients with any degree of heart block.
- Sever liver, respiratory or renal impairment.
Sites / Locations
- Zagazig University Hospitsals
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
dexmedetomidine- ketamine
dexmedetomidine- propofol
patients will receive combination of ketamine 1mg/kg and dexmedetomidine 1ug/kg diluted in 10 ml 0.9% saline infused over 10 min together as an intravenous bolus dose then a maintenance of 0.5ug/kg/h dexmedetomidine and ketamine 0.5 mg/kg/h continuous infusion in two separate syringes pump to achieve modified Observer's Assessment of Alertness and sedation score (OAA/S) 3 and the infusion will stopped by finishing the skin suture.
patients will receive combination from 1 mg/kg propofol and dexmedetomidine 1ug/kg diluted in 10 ml 0.9% saline infused over 10 min together as an intravenous bolus dose then a maintenance of 0.5ug/kg/h dexmedetomidine and propofol 1 mg/kg/h continuous infusion in two separate syringes pump to achieve modified Observer's Assessment of Alertness and sedation score (OAA/S) 3 and the infusion will stopped by finishing the skin suture.