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MOre REsponse on Cardiac Resynchronization Therapy With MultiPoint Pacing (MORE CRT MPP)

Primary Purpose

Heart Failure

Status
Terminated
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
MPP
Sponsored by
Abbott Medical Devices
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Heart Failure focused on measuring CRT, non responders, MultiPoint Pacing (MPP)

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Meets the current ESC Guidelines or ACCF/AHA/HRS Class I or Class IIa indications for CRT implant (including upgrades from single or dual chamber ICDs)
  • Must be willing and able to comply with study requirements
  • Must indicate their understanding of the study and willingness to participate by signing an appropriate informed consent form

Exclusion Criteria:

  • Already had a CRT device implanted
  • Myocardial Infarction, unstable angina within 40 days prior the enrollment
  • Recent cardiac revascularization (PTCA, Stent or CABG) in the 4 weeks prior to enrollment or planned for the 3 months following
  • Cerebrovascular Accident (CVA) or Transient Ischemic Attack (TIA) in the 3 months prior the enrollment
  • Primary valvular disease

  • Atrial Fibrillation:

    • Persistent AF at the time of enrollment
    • Permanent AF not treated with AV node ablation within 2 weeks from the CRT implant
    • History or incidence of Paroxysmal or Persistent AF within 30 days prior the enrollment
  • Unable to comply with the follow up schedule
  • Less than 18 years of age
  • Pregnant or are planning to become pregnant during the duration of the investigation
  • Classification of Status 1 for cardiac transplantation or consideration for transplantation over the next 12 months
  • Undergone a cardiac transplantation
  • Life expectancy < 12 months
  • Currently participating in any other clinical investigation

Sites / Locations

  • Heart Center Research, LLC.
  • Cardiovascular Associates of Mesa
  • Phoenix Cardiovascular Research Group
  • Comprehensive Cardiovascular
  • Glendale Adventist Medical Center
  • Scripps Health
  • Eisenhower Medical Center
  • Cardiac Rhythm Specialists, Inc.
  • San Diego Cardiac Center
  • Colorado Heart & Vascular, P.C.
  • Sarasota Memorial Hospital
  • Coliseum Medical Centers
  • Redmond Regional Medical Center
  • St. Elizabeth Medical Center - South Unit
  • Baptist Health Lexington
  • Brigham and Women's Hospital
  • McLaren Health Care Corporation
  • MidMichigan Medical Center-Midland
  • Munson Medical Center
  • CHI Health Creighton University Medical Center-Bergan Mercy
  • Deborah Heart and Lung Center
  • Cardiology Associates of Fairfield County, PC
  • Samaritan Heart & Vascular Institute - Cardiology Dept.
  • Lancaster General Hospital
  • St. Francis Hospital
  • Erlanger Medical Center
  • Methodist University Hospital
  • University of Texas Southwestern Medical Center at Dallas
  • Baylor All Saints Medical Center at Fort Worth
  • Memorial Katy Cardiology Associates
  • Vivek Mangla, MD
  • EP Heart
  • Royal Adelaide Hospital
  • Flinders Medical Centre
  • St. Andrews War Memorial Hospital
  • The Alfred Hospital
  • Westmead Hospital
  • Krankenhaus der Stadt St. Poelten
  • Krankenhaus Hietzing
  • Wilhelminenspital
  • Hopital Erasme
  • St. Joseph Gilly
  • Foothills Medical Centre
  • Royal Alexandra Hospital
  • QEII Health Sciences
  • Kingston General Hospital
  • Institut de Cardiologie de Montreal
  • Hôtel Dieu de CHUM
  • McGill University Health Centre General Hospital
  • Institut de Cardiologie de Quebec
  • CHUS Fleurimont
  • HSC, Eastern Health
  • Rouge Valley Centenary
  • St. Paul's Hospital
  • Prince of Wales Hospital
  • Angiografia Clinica de Occidente
  • Clínica Cardio VID
  • Odense University Hospital
  • Aalborg Sygehus Syd
  • Skejby University Hospital
  • Keski-Suomi Central Hospital
  • Turku University Hospital
  • Hôpital Clairval
  • CHU Cavale Blanche
  • CHU Trousseau
  • CHU François Mitterrand Dijon Bourgogne
  • CHRU Albert Michallon
  • CHRU Lille
  • Hopital Saint Philibert
  • Hôpital Saint Joseph
  • Centre Hospitalier de Belfort-Montbeliard
  • CHU Montpellier
  • CHU de Nancy - Hopital de Brabois
  • CHU Hopital G. & R. Laënnec
  • Nouvelles cliniques Nantaises
  • Centre Cardiologique Du Nord
  • Hopital Pitiè Salpetrière
  • Institute Cardio. Paris-Sud - Institut Jacques Cartier
  • CHRU Hôpital de Pontchaillou
  • CHRU Rouen Hospital Charles Nicolle
  • CHR de La Reunion - Site du CHFG
  • Centre Hospitalier de Valence
  • Clinique du Tonkin
  • Hegau-Bodensee-Hochrhein-Kliniken GmbH
  • Universitäts-Herzzentrum Freiburg - Bad Krozingen
  • Kerckhoff-Klinik gGmbH
  • Herz- und Gefäßzentrum am Krankenhaus Neu-Bethlehem
  • Medizinische Hochschule Hannover
  • Medizinische Einrichtungen der Universität zu Köln
  • Evangelisches Krankenhaus Kalk gGmbH
  • Herz-und Diabetes Zentrum NRW
  • Schuchtermann-Schillersche Kliniken
  • Charite Campus Virchow Klinikum
  • Universitatsmedizin Berlin - Campus Benjamin Franklin (CBF)
  • Klinikum Bielefeld
  • Berufsgenossenschaftliche Kliniken Bergmannsheil
  • Klinikum Coburg
  • Helios-Klinikum Erfurt GmbH
  • Kliniken der Friedrich-Alexander-Universität
  • Elisabeth-Krankenhaus Essen GmbH
  • Universitatsklinikum Greifswald
  • Universitätsmedizin Göttingen Georg-August-Universität
  • Klinikum Gütersloh gGmbH
  • Albertinen-Krankenhaus Hamburg
  • Klinikum Ingolstadt
  • St. Vinzenz-Hospital
  • Klinikum St. Georg gGMbH
  • Universitatsklinikum Leipzig
  • Klinikum Ludenscheid
  • St.-Marien-Hospital GmbH
  • Universitatsklinikum Muenster
  • Deutsches Herzzentrum München des Freistaates Bayern
  • Klinikum Oldenburg
  • Krankenhaus der Barmherzigen Bruder
  • Kliniken Villingen-Schwenningen
  • Universitätsklinikum Würzburg
  • The Onassis Cardiac Center
  • Medanta - The Medicity Hospital
  • Fortis Hospital
  • Care Institute of Medical Sciences
  • Postgraduate Institute of Medical Education & Research
  • Apollo Hospital
  • CARE Banjara
  • Medanta Medicity Hospital
  • Escorts Heart Institute and Research Centre
  • Rabin Medical Center
  • Sheba Medical Center
  • Tel Aviv Medical Center
  • Az.Osp.Universitaria Consorziale Policlinico
  • Azienda Ospedaliera Di Venere
  • Policlinico S.Orsola Malpighi
  • Az. Osp. Spedali Civili di Brescia
  • Azienda Ospedaliera S. Anna e S Sebastiano
  • Presidio Osp. Vito Fazzi
  • Clinica Mediterranea
  • Ospedale dei Pellegrini
  • Ospedale S. Giovanni Bosco
  • Az Osp.Universitaria Maggiore della Carità
  • Università degli Studi di Padova
  • Casa di Cura Dott. Pederzoli
  • Az. Osp. Universitaria Pisana-Presidio Santa Chiara
  • Ospedale di Portogruaro
  • Azienda Ospedaliera "Civile - Maria Paternò Arezzo"
  • Ospedale Madre G. Vannini
  • Policlinico Casilino
  • Ospedale S. Giovanni Calibita Fatebenefratelli di Roma
  • Azienda Ospedaliera S. Anna
  • Casa Sollievo della Sofferenza
  • Ospedale Civile Maggiore di Verona Borgo Trento
  • Samsung Medical Center
  • Seoul St. Mary's Hospital
  • Sejong General Hospital
  • Seoul National University Bundang Hospital
  • Seoul National University Hospital
  • Yonsei University Health System
  • American University of Beirut Medical Center
  • Institut Jantung Negara
  • Mater Dei Hospital
  • Twee Steden Ziekenhuis
  • Amsterdam Academic Medical Center (AMC)
  • Catharina Ziekenhuis
  • Medisch Spectrum Twente
  • Isala Ziekenhuis
  • Gornoslaskie Centrum Medyczne im.prof. Leszka Gieca
  • Slaskie Centrum Chorob Serca
  • Szpital Kliniczny Premienienia Panskiego
  • Wojewodzki Specjalistyczny Szpital im. Bieganskiego
  • Hospital de Braga
  • Centro Hospitalar do Alto Ave, Unidade de Guimarães
  • Hospital Garcia de Orta, EPE
  • Hospital de Santa Cruz
  • Santa Maria Hospital
  • Centro Hospitalar Vila Nova Gaia
  • Arrhythmia Group
  • Heart Rhythm Management
  • King Fahad Armed Forces Hospital
  • King Fahad Medical City
  • National University Hospital
  • Hospital Universitario A Coruña
  • Hospital Universitario Infanta Cristina
  • Hospital de la Santa Creu y Sant Pau
  • Hospital Universitario Virgen de la Nieves
  • Complexo Hospitalario Universitario de Santiago
  • Fundación Jiménez Díaz
  • Hospital General Universitario Gregorio Maranon
  • Hospital Ramon y Cajal
  • Hospital Universitario Doce de Octubre
  • Hospital Universitario Puerta de Hierro
  • HCU Virgen de la Victoria
  • Hospital Universitari i Politecnic La Fe
  • Hospital Alvaro Cunqueiro
  • Hospital Universitario Miguel Servet
  • Karolinska University Hospital Huddinge
  • Hopital Cantonal Universitaire de Geneva
  • National Taiwan University
  • Chang Gung Memorial Hospital
  • Wansbeck General Hospital
  • Queen Elizabeth Hospital
  • The Royal Sussex Country Hospital
  • Golden Jubilee National Hospital
  • Kings College Hospital
  • St. Thomas Hospital
  • Manchester Heart Center, Manchester Royal Infirmary
  • John Radcliffe Hospital
  • Southampton General Hospital
  • The Great Western Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

MPP ON

MPP OFF

Arm Description

MPP ON: feature is enabled

MPP OFF: feature not enabled

Outcomes

Primary Outcome Measures

Percentage of Non-responder Patients Who Converted to Responders
The primary endpoint of this study is evaluated at 12 months after enrollment and it is defined as the percentage of non-responder patients converted to responders after 6 months of MPP feature turned ON compared to baseline, as measured by Left Ventricular End Systolic Volume (LVESV) reduction of at least 15%.

Secondary Outcome Measures

Reduction of Left Ventricular End-systolic Volume (LVESV) in Acute Phase
Reduction of LVESV between baseline and 6 Months visit
Clinical Composite Score Evaluation
Packer's Clinical Composite Score evaluation between baseline and 12 months as defined below, Worsened: the patient died because of cardiovascular reasons OR experienced a HF event OR demonstrated worsening in NYHA functional class, or had worsening of patient global assessment (PGA) score compared with the last observation Improved: the patient survived without an HF event AND demonstrated either improvement in NYHA functional class or improvement in PGA score or both compared with the last observation Unchanged: the patient was neither improved nor worsened
Reverse Left Ventricular (LV) Remodeling
Evaluation of Reverse LV remodeling, measured as changed in left ventricular end-systolic volume (LVESV) from baseline to 12 months
NYHA Class Changes
Evaluation of NYHA Class changes between baseline and 12 months. Increasing functional class is associated with greater risk of death or hospitalization.
6MWT Changes
Evaluation of the patient's activity status using 6 Minutes Walking Test changes from baseline to 12 months FU
Patient's QoL Score Changes (MLWHF)
Evaluation of patient's Quality of Life score using Minnesota Living with Heart Failure (MLWHF) Questionnaires. The MLWHF Questionnaire consists of 21 questions with a range in overall scores of 0 to 105 points (lower scores indicate better quality of life).

Full Information

First Posted
September 23, 2013
Last Updated
April 21, 2023
Sponsor
Abbott Medical Devices
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1. Study Identification

Unique Protocol Identification Number
NCT02006069
Brief Title
MOre REsponse on Cardiac Resynchronization Therapy With MultiPoint Pacing
Acronym
MORE CRT MPP
Official Title
MOre REsponse on Cardiac Resynchronization Therapy (CRT) With MultiPoint Pacing (MPP)
Study Type
Interventional

2. Study Status

Record Verification Date
April 2023
Overall Recruitment Status
Terminated
Why Stopped
The steering committee had decided to discontinue enrollment because the interim analysis showed a low probability that the study would meet the primary endpoint. The interim analysis did not demonstrate any safety concerns with activating MPP.
Study Start Date
December 2013 (undefined)
Primary Completion Date
May 30, 2021 (Actual)
Study Completion Date
May 30, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Abbott Medical Devices

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this Clinical investigation is to assess the impact of the Multi Point Pacing (MPP) feature at 12 months in the treatment of patients not responding to standard Cardiac Resynchronization Therapy (CRT) after 6 months.
Detailed Description
This study is designed as a prospective, randomized, multi-center trial. Data will be collected at enrollment, baseline, implant procedure, patient classification, 6 months and 12 months of follow-up. During the 6-month visit, the patient's response to CRT will be evaluated according to LVESV reduction. Patients with an LVESV reduction of at least 15% will be classified as responders. These patients will terminate their participation in the study and return to the center's standard practice. Patients with an LVESV reduction less than 15% will be classified as non-responders and the MPP feature will be activated according to randomization result and they will be followed until the 12-month visit.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Heart Failure
Keywords
CRT, non responders, MultiPoint Pacing (MPP)

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
5850 (Actual)

8. Arms, Groups, and Interventions

Arm Title
MPP ON
Arm Type
Experimental
Arm Description
MPP ON: feature is enabled
Arm Title
MPP OFF
Arm Type
No Intervention
Arm Description
MPP OFF: feature not enabled
Intervention Type
Device
Intervention Name(s)
MPP
Intervention Description
All patients enrolled in the study will be implanted (according to current Guidelines) with an MPP compatible CRT device. The MPP feature will be evaluated in two study phases. Patients randomized to MPP in Phase I will have MPP programmed per the physician's discretion ("no mandated MPP programming") and patients randomized to MPP in Phase II will have MPP programmed per protocol requirements ("mandated MPP programming").
Primary Outcome Measure Information:
Title
Percentage of Non-responder Patients Who Converted to Responders
Description
The primary endpoint of this study is evaluated at 12 months after enrollment and it is defined as the percentage of non-responder patients converted to responders after 6 months of MPP feature turned ON compared to baseline, as measured by Left Ventricular End Systolic Volume (LVESV) reduction of at least 15%.
Time Frame
Non-responder to responder conversion rate between randomization at 6 months and 12 months
Secondary Outcome Measure Information:
Title
Reduction of Left Ventricular End-systolic Volume (LVESV) in Acute Phase
Description
Reduction of LVESV between baseline and 6 Months visit
Time Frame
Baseline vs 6 Months
Title
Clinical Composite Score Evaluation
Description
Packer's Clinical Composite Score evaluation between baseline and 12 months as defined below, Worsened: the patient died because of cardiovascular reasons OR experienced a HF event OR demonstrated worsening in NYHA functional class, or had worsening of patient global assessment (PGA) score compared with the last observation Improved: the patient survived without an HF event AND demonstrated either improvement in NYHA functional class or improvement in PGA score or both compared with the last observation Unchanged: the patient was neither improved nor worsened
Time Frame
Baseline vs 12 Months
Title
Reverse Left Ventricular (LV) Remodeling
Description
Evaluation of Reverse LV remodeling, measured as changed in left ventricular end-systolic volume (LVESV) from baseline to 12 months
Time Frame
Baseline vs 12 Months
Title
NYHA Class Changes
Description
Evaluation of NYHA Class changes between baseline and 12 months. Increasing functional class is associated with greater risk of death or hospitalization.
Time Frame
Baseline vs 12 Months
Title
6MWT Changes
Description
Evaluation of the patient's activity status using 6 Minutes Walking Test changes from baseline to 12 months FU
Time Frame
Baseline vs 12 Months
Title
Patient's QoL Score Changes (MLWHF)
Description
Evaluation of patient's Quality of Life score using Minnesota Living with Heart Failure (MLWHF) Questionnaires. The MLWHF Questionnaire consists of 21 questions with a range in overall scores of 0 to 105 points (lower scores indicate better quality of life).
Time Frame
Baseline vs 12 Months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Meets the current ESC Guidelines or ACCF/AHA/HRS Class I or Class IIa indications for CRT implant (including upgrades from single or dual chamber ICDs) Must be willing and able to comply with study requirements Must indicate their understanding of the study and willingness to participate by signing an appropriate informed consent form Exclusion Criteria: Already had a CRT device implanted Myocardial Infarction, unstable angina within 40 days prior the enrollment Recent cardiac revascularization (PTCA, Stent or CABG) in the 4 weeks prior to enrollment or planned for the 3 months following Cerebrovascular Accident (CVA) or Transient Ischemic Attack (TIA) in the 3 months prior the enrollment Primary valvular disease Atrial Fibrillation: Persistent AF at the time of enrollment Permanent AF not treated with AV node ablation within 2 weeks from the CRT implant History or incidence of Paroxysmal or Persistent AF within 30 days prior the enrollment Unable to comply with the follow up schedule Less than 18 years of age Pregnant or are planning to become pregnant during the duration of the investigation Classification of Status 1 for cardiac transplantation or consideration for transplantation over the next 12 months Undergone a cardiac transplantation Life expectancy < 12 months Currently participating in any other clinical investigation
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Christophe Leclercq
Organizational Affiliation
Centre Cardio-Pneumologique, CHU Pontchaillou
Official's Role
Study Chair
Facility Information:
Facility Name
Heart Center Research, LLC.
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Cardiovascular Associates of Mesa
City
Mesa
State/Province
Arizona
ZIP/Postal Code
85206
Country
United States
Facility Name
Phoenix Cardiovascular Research Group
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85018
Country
United States
Facility Name
Comprehensive Cardiovascular
City
Bakersfield
State/Province
California
ZIP/Postal Code
93309
Country
United States
Facility Name
Glendale Adventist Medical Center
City
Glendale
State/Province
California
ZIP/Postal Code
91206
Country
United States
Facility Name
Scripps Health
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Eisenhower Medical Center
City
Rancho Mirage
State/Province
California
ZIP/Postal Code
92270
Country
United States
Facility Name
Cardiac Rhythm Specialists, Inc.
City
Reseda
State/Province
California
ZIP/Postal Code
91335
Country
United States
Facility Name
San Diego Cardiac Center
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Facility Name
Colorado Heart & Vascular, P.C.
City
Lakewood
State/Province
Colorado
ZIP/Postal Code
80228
Country
United States
Facility Name
Sarasota Memorial Hospital
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Coliseum Medical Centers
City
Macon
State/Province
Georgia
ZIP/Postal Code
31217
Country
United States
Facility Name
Redmond Regional Medical Center
City
Rome
State/Province
Georgia
ZIP/Postal Code
30165
Country
United States
Facility Name
St. Elizabeth Medical Center - South Unit
City
Edgewood
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
Baptist Health Lexington
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
Brigham and Women's Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
McLaren Health Care Corporation
City
Auburn Hills
State/Province
Michigan
ZIP/Postal Code
48326
Country
United States
Facility Name
MidMichigan Medical Center-Midland
City
Midland
State/Province
Michigan
ZIP/Postal Code
48670
Country
United States
Facility Name
Munson Medical Center
City
Traverse City
State/Province
Michigan
ZIP/Postal Code
49684
Country
United States
Facility Name
CHI Health Creighton University Medical Center-Bergan Mercy
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68124
Country
United States
Facility Name
Deborah Heart and Lung Center
City
Browns Mills
State/Province
New Jersey
ZIP/Postal Code
08015
Country
United States
Facility Name
Cardiology Associates of Fairfield County, PC
City
Haddon Heights
State/Province
New Jersey
ZIP/Postal Code
08035
Country
United States
Facility Name
Samaritan Heart & Vascular Institute - Cardiology Dept.
City
Corvallis
State/Province
Oregon
ZIP/Postal Code
97330
Country
United States
Facility Name
Lancaster General Hospital
City
Lancaster
State/Province
Pennsylvania
ZIP/Postal Code
17602
Country
United States
Facility Name
St. Francis Hospital
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29601
Country
United States
Facility Name
Erlanger Medical Center
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37403
Country
United States
Facility Name
Methodist University Hospital
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
University of Texas Southwestern Medical Center at Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-9016
Country
United States
Facility Name
Baylor All Saints Medical Center at Fort Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Memorial Katy Cardiology Associates
City
Houston
State/Province
Texas
ZIP/Postal Code
77094
Country
United States
Facility Name
Vivek Mangla, MD
City
Lufkin
State/Province
Texas
ZIP/Postal Code
75904
Country
United States
Facility Name
EP Heart
City
The Woodlands
State/Province
Texas
ZIP/Postal Code
77384
Country
United States
Facility Name
Royal Adelaide Hospital
City
Adelaide
Country
Australia
Facility Name
Flinders Medical Centre
City
Bedford Park
ZIP/Postal Code
5042
Country
Australia
Facility Name
St. Andrews War Memorial Hospital
City
Brisbane
Country
Australia
Facility Name
The Alfred Hospital
City
Melbourne
Country
Australia
Facility Name
Westmead Hospital
City
Westmead
Country
Australia
Facility Name
Krankenhaus der Stadt St. Poelten
City
St. Poelten
Country
Austria
Facility Name
Krankenhaus Hietzing
City
Vienna
ZIP/Postal Code
1130
Country
Austria
Facility Name
Wilhelminenspital
City
Vienna
Country
Austria
Facility Name
Hopital Erasme
City
Brussels
Country
Belgium
Facility Name
St. Joseph Gilly
City
Gilly
Country
Belgium
Facility Name
Foothills Medical Centre
City
Calgary
Country
Canada
Facility Name
Royal Alexandra Hospital
City
Edmonton
Country
Canada
Facility Name
QEII Health Sciences
City
Halifax
Country
Canada
Facility Name
Kingston General Hospital
City
Kingston
Country
Canada
Facility Name
Institut de Cardiologie de Montreal
City
Montreal
Country
Canada
Facility Name
Hôtel Dieu de CHUM
City
Montréal
Country
Canada
Facility Name
McGill University Health Centre General Hospital
City
Montréal
Country
Canada
Facility Name
Institut de Cardiologie de Quebec
City
Sainte-Foy
Country
Canada
Facility Name
CHUS Fleurimont
City
Sherbrooke
ZIP/Postal Code
J1H 5N4
Country
Canada
Facility Name
HSC, Eastern Health
City
St. Johns
Country
Canada
Facility Name
Rouge Valley Centenary
City
Toronto
Country
Canada
Facility Name
St. Paul's Hospital
City
Vancouver
Country
Canada
Facility Name
Prince of Wales Hospital
City
Hong Kong
Country
China
Facility Name
Angiografia Clinica de Occidente
City
Cali
Country
Colombia
Facility Name
Clínica Cardio VID
City
Medellín
Country
Colombia
Facility Name
Odense University Hospital
City
Odense
State/Province
Fyn
ZIP/Postal Code
5000
Country
Denmark
Facility Name
Aalborg Sygehus Syd
City
Aalborg
State/Province
Nordjylland
ZIP/Postal Code
DK-9000
Country
Denmark
Facility Name
Skejby University Hospital
City
Aarhus
Country
Denmark
Facility Name
Keski-Suomi Central Hospital
City
Jyvaskyla
Country
Finland
Facility Name
Turku University Hospital
City
Turku
Country
Finland
Facility Name
Hôpital Clairval
City
Marseille
State/Province
Alpes
ZIP/Postal Code
13009
Country
France
Facility Name
CHU Cavale Blanche
City
Brest
Country
France
Facility Name
CHU Trousseau
City
Chambray-lès-Tours
Country
France
Facility Name
CHU François Mitterrand Dijon Bourgogne
City
Dijon
Country
France
Facility Name
CHRU Albert Michallon
City
Grenoble
Country
France
Facility Name
CHRU Lille
City
Lille
Country
France
Facility Name
Hopital Saint Philibert
City
Lomme
Country
France
Facility Name
Hôpital Saint Joseph
City
Marseille
Country
France
Facility Name
Centre Hospitalier de Belfort-Montbeliard
City
Montbéliard
Country
France
Facility Name
CHU Montpellier
City
Montpellier
Country
France
Facility Name
CHU de Nancy - Hopital de Brabois
City
Nancy
Country
France
Facility Name
CHU Hopital G. & R. Laënnec
City
Nantes
ZIP/Postal Code
44093
Country
France
Facility Name
Nouvelles cliniques Nantaises
City
Nantes
Country
France
Facility Name
Centre Cardiologique Du Nord
City
Paris
Country
France
Facility Name
Hopital Pitiè Salpetrière
City
Paris
Country
France
Facility Name
Institute Cardio. Paris-Sud - Institut Jacques Cartier
City
Paris
Country
France
Facility Name
CHRU Hôpital de Pontchaillou
City
Rennes
ZIP/Postal Code
35033
Country
France
Facility Name
CHRU Rouen Hospital Charles Nicolle
City
Rouen
Country
France
Facility Name
CHR de La Reunion - Site du CHFG
City
Saint-Denis Cedex
ZIP/Postal Code
97405
Country
France
Facility Name
Centre Hospitalier de Valence
City
Valence
Country
France
Facility Name
Clinique du Tonkin
City
Villeurbanne
Country
France
Facility Name
Hegau-Bodensee-Hochrhein-Kliniken GmbH
City
Singen
State/Province
Baden-Wurttemberg
ZIP/Postal Code
78224
Country
Germany
Facility Name
Universitäts-Herzzentrum Freiburg - Bad Krozingen
City
Bad Krozingen
State/Province
Baden-Württemberg
ZIP/Postal Code
79189
Country
Germany
Facility Name
Kerckhoff-Klinik gGmbH
City
Bad Nauheim
State/Province
Hessen
ZIP/Postal Code
61231
Country
Germany
Facility Name
Herz- und Gefäßzentrum am Krankenhaus Neu-Bethlehem
City
Göttingen
State/Province
Niedersachsen
ZIP/Postal Code
37073
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Facility Name
Medizinische Einrichtungen der Universität zu Köln
City
Köln
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
50931
Country
Germany
Facility Name
Evangelisches Krankenhaus Kalk gGmbH
City
Köln
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
51103
Country
Germany
Facility Name
Herz-und Diabetes Zentrum NRW
City
Bad Oeynhausen
Country
Germany
Facility Name
Schuchtermann-Schillersche Kliniken
City
Bad Rothenfelde
Country
Germany
Facility Name
Charite Campus Virchow Klinikum
City
Berlin
Country
Germany
Facility Name
Universitatsmedizin Berlin - Campus Benjamin Franklin (CBF)
City
Berlin
Country
Germany
Facility Name
Klinikum Bielefeld
City
Bielefeld
Country
Germany
Facility Name
Berufsgenossenschaftliche Kliniken Bergmannsheil
City
Bochum
Country
Germany
Facility Name
Klinikum Coburg
City
Coburg
Country
Germany
Facility Name
Helios-Klinikum Erfurt GmbH
City
Erfurt
Country
Germany
Facility Name
Kliniken der Friedrich-Alexander-Universität
City
Erlangen
Country
Germany
Facility Name
Elisabeth-Krankenhaus Essen GmbH
City
Essen
Country
Germany
Facility Name
Universitatsklinikum Greifswald
City
Greifswald
Country
Germany
Facility Name
Universitätsmedizin Göttingen Georg-August-Universität
City
Göttingen
Country
Germany
Facility Name
Klinikum Gütersloh gGmbH
City
Gütersloh
Country
Germany
Facility Name
Albertinen-Krankenhaus Hamburg
City
Hamburg
ZIP/Postal Code
22457
Country
Germany
Facility Name
Klinikum Ingolstadt
City
Ingolstadt
Country
Germany
Facility Name
St. Vinzenz-Hospital
City
Köln
Country
Germany
Facility Name
Klinikum St. Georg gGMbH
City
Leipzig
Country
Germany
Facility Name
Universitatsklinikum Leipzig
City
Leipzig
Country
Germany
Facility Name
Klinikum Ludenscheid
City
Ludenscheid
Country
Germany
Facility Name
St.-Marien-Hospital GmbH
City
Lünen
Country
Germany
Facility Name
Universitatsklinikum Muenster
City
Muenster
Country
Germany
Facility Name
Deutsches Herzzentrum München des Freistaates Bayern
City
München
Country
Germany
Facility Name
Klinikum Oldenburg
City
Oldenburg
Country
Germany
Facility Name
Krankenhaus der Barmherzigen Bruder
City
Trier
Country
Germany
Facility Name
Kliniken Villingen-Schwenningen
City
Villingen-Schwenningen
Country
Germany
Facility Name
Universitätsklinikum Würzburg
City
Würzburg
Country
Germany
Facility Name
The Onassis Cardiac Center
City
Athens
ZIP/Postal Code
17674
Country
Greece
Facility Name
Medanta - The Medicity Hospital
City
Gurgaon
State/Province
Haryana
ZIP/Postal Code
122 001
Country
India
Facility Name
Fortis Hospital
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560076
Country
India
Facility Name
Care Institute of Medical Sciences
City
Ahmedabad
Country
India
Facility Name
Postgraduate Institute of Medical Education & Research
City
Chandigarh
Country
India
Facility Name
Apollo Hospital
City
Chennai
Country
India
Facility Name
CARE Banjara
City
Hyderabad
Country
India
Facility Name
Medanta Medicity Hospital
City
New Delhi
ZIP/Postal Code
110017
Country
India
Facility Name
Escorts Heart Institute and Research Centre
City
New Delhi
Country
India
Facility Name
Rabin Medical Center
City
Petah Tikva
ZIP/Postal Code
49100
Country
Israel
Facility Name
Sheba Medical Center
City
Ramat Gan
Country
Israel
Facility Name
Tel Aviv Medical Center
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Az.Osp.Universitaria Consorziale Policlinico
City
Bari
Country
Italy
Facility Name
Azienda Ospedaliera Di Venere
City
Bari
Country
Italy
Facility Name
Policlinico S.Orsola Malpighi
City
Bologna
Country
Italy
Facility Name
Az. Osp. Spedali Civili di Brescia
City
Brescia
Country
Italy
Facility Name
Azienda Ospedaliera S. Anna e S Sebastiano
City
Caserta
Country
Italy
Facility Name
Presidio Osp. Vito Fazzi
City
Lecce
Country
Italy
Facility Name
Clinica Mediterranea
City
Naples
Country
Italy
Facility Name
Ospedale dei Pellegrini
City
Naples
Country
Italy
Facility Name
Ospedale S. Giovanni Bosco
City
Naples
Country
Italy
Facility Name
Az Osp.Universitaria Maggiore della Carità
City
Novara
Country
Italy
Facility Name
Università degli Studi di Padova
City
Padova
ZIP/Postal Code
35128
Country
Italy
Facility Name
Casa di Cura Dott. Pederzoli
City
Peschiera del Garda
Country
Italy
Facility Name
Az. Osp. Universitaria Pisana-Presidio Santa Chiara
City
Pisa
Country
Italy
Facility Name
Ospedale di Portogruaro
City
Portogruaro
Country
Italy
Facility Name
Azienda Ospedaliera "Civile - Maria Paternò Arezzo"
City
Ragusa
Country
Italy
Facility Name
Ospedale Madre G. Vannini
City
Roma
ZIP/Postal Code
00177
Country
Italy
Facility Name
Policlinico Casilino
City
Roma
Country
Italy
Facility Name
Ospedale S. Giovanni Calibita Fatebenefratelli di Roma
City
Rome
Country
Italy
Facility Name
Azienda Ospedaliera S. Anna
City
San Fermo della Battaglia
ZIP/Postal Code
1 22020
Country
Italy
Facility Name
Casa Sollievo della Sofferenza
City
San Giovanni Rotondo
ZIP/Postal Code
71013
Country
Italy
Facility Name
Ospedale Civile Maggiore di Verona Borgo Trento
City
Verona
Country
Italy
Facility Name
Samsung Medical Center
City
Seoul
State/Province
Gangnam-gu
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Seoul St. Mary's Hospital
City
Seoul
State/Province
Seocho-gu
ZIP/Postal Code
137-701
Country
Korea, Republic of
Facility Name
Sejong General Hospital
City
Bucheon-si
Country
Korea, Republic of
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
Country
Korea, Republic of
Facility Name
Yonsei University Health System
City
Seoul
Country
Korea, Republic of
Facility Name
American University of Beirut Medical Center
City
Beirut
Country
Lebanon
Facility Name
Institut Jantung Negara
City
Kuala Lumpur
ZIP/Postal Code
50400
Country
Malaysia
Facility Name
Mater Dei Hospital
City
Paola
Country
Malta
Facility Name
Twee Steden Ziekenhuis
City
Tilburg
State/Province
Noord-Brabant
ZIP/Postal Code
5042 AD
Country
Netherlands
Facility Name
Amsterdam Academic Medical Center (AMC)
City
Amsterdam
Country
Netherlands
Facility Name
Catharina Ziekenhuis
City
Eindhoven
Country
Netherlands
Facility Name
Medisch Spectrum Twente
City
Enschede
Country
Netherlands
Facility Name
Isala Ziekenhuis
City
Zwolle
Country
Netherlands
Facility Name
Gornoslaskie Centrum Medyczne im.prof. Leszka Gieca
City
Katowice
State/Province
Slaskie
ZIP/Postal Code
40-635
Country
Poland
Facility Name
Slaskie Centrum Chorob Serca
City
Zabrze
State/Province
Slask
ZIP/Postal Code
41-800
Country
Poland
Facility Name
Szpital Kliniczny Premienienia Panskiego
City
Poznan
State/Province
Wielkopolskie
ZIP/Postal Code
61-848
Country
Poland
Facility Name
Wojewodzki Specjalistyczny Szpital im. Bieganskiego
City
Lodz
Country
Poland
Facility Name
Hospital de Braga
City
Braga
Country
Portugal
Facility Name
Centro Hospitalar do Alto Ave, Unidade de Guimarães
City
Creixomil
ZIP/Postal Code
4835-044
Country
Portugal
Facility Name
Hospital Garcia de Orta, EPE
City
Lisboa
Country
Portugal
Facility Name
Hospital de Santa Cruz
City
Lisbon
Country
Portugal
Facility Name
Santa Maria Hospital
City
Lisbon
Country
Portugal
Facility Name
Centro Hospitalar Vila Nova Gaia
City
Vila Nova de Gaia
ZIP/Postal Code
4434 502
Country
Portugal
Facility Name
Arrhythmia Group
City
Ponce
Country
Puerto Rico
Facility Name
Heart Rhythm Management
City
San Juan
Country
Puerto Rico
Facility Name
King Fahad Armed Forces Hospital
City
Jeddah
ZIP/Postal Code
21159
Country
Saudi Arabia
Facility Name
King Fahad Medical City
City
Riyadh
Country
Saudi Arabia
Facility Name
National University Hospital
City
Singapore
Country
Singapore
Facility Name
Hospital Universitario A Coruña
City
A Coruña
Country
Spain
Facility Name
Hospital Universitario Infanta Cristina
City
Badajoz
Country
Spain
Facility Name
Hospital de la Santa Creu y Sant Pau
City
Barcelona
Country
Spain
Facility Name
Hospital Universitario Virgen de la Nieves
City
Granada
Country
Spain
Facility Name
Complexo Hospitalario Universitario de Santiago
City
Madrid
ZIP/Postal Code
15706
Country
Spain
Facility Name
Fundación Jiménez Díaz
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital General Universitario Gregorio Maranon
City
Madrid
Country
Spain
Facility Name
Hospital Ramon y Cajal
City
Madrid
Country
Spain
Facility Name
Hospital Universitario Doce de Octubre
City
Madrid
Country
Spain
Facility Name
Hospital Universitario Puerta de Hierro
City
Madrid
Country
Spain
Facility Name
HCU Virgen de la Victoria
City
Malaga
Country
Spain
Facility Name
Hospital Universitari i Politecnic La Fe
City
Valencia
Country
Spain
Facility Name
Hospital Alvaro Cunqueiro
City
Vigo
Country
Spain
Facility Name
Hospital Universitario Miguel Servet
City
Zaragoza
Country
Spain
Facility Name
Karolinska University Hospital Huddinge
City
Stockholm
Country
Sweden
Facility Name
Hopital Cantonal Universitaire de Geneva
City
Geneva
Country
Switzerland
Facility Name
National Taiwan University
City
Taipei City
State/Province
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital
City
LinKou
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Wansbeck General Hospital
City
Ashington
Country
United Kingdom
Facility Name
Queen Elizabeth Hospital
City
Birmingham
ZIP/Postal Code
B15 2TH
Country
United Kingdom
Facility Name
The Royal Sussex Country Hospital
City
Brighton
Country
United Kingdom
Facility Name
Golden Jubilee National Hospital
City
Glasgow
Country
United Kingdom
Facility Name
Kings College Hospital
City
London
Country
United Kingdom
Facility Name
St. Thomas Hospital
City
London
Country
United Kingdom
Facility Name
Manchester Heart Center, Manchester Royal Infirmary
City
Manchester
ZIP/Postal Code
M13 9WL
Country
United Kingdom
Facility Name
John Radcliffe Hospital
City
Oxford
Country
United Kingdom
Facility Name
Southampton General Hospital
City
Southampton
Country
United Kingdom
Facility Name
The Great Western Hospital
City
Swindon
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
30859220
Citation
Leclercq C, Burri H, Curnis A, Delnoy PP, Rinaldi CA, Sperzel J, Lee K, Calo L, Vicentini A, Concha JF, Thibault B. Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP) study: results from Phase I. Eur Heart J. 2019 Sep 14;40(35):2979-2987. doi: 10.1093/eurheartj/ehz109.
Results Reference
derived
PubMed Identifier
30616009
Citation
Leclercq C, Burri H, Curnis A, Delnoy PP, Rinaldi CA, Sperzel J, Lee K, Cohorn C, Thibault B; MORE-CRT MPP Investigators. Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II). Am Heart J. 2019 Mar;209:1-8. doi: 10.1016/j.ahj.2018.12.004. Epub 2018 Dec 8.
Results Reference
derived

Learn more about this trial

MOre REsponse on Cardiac Resynchronization Therapy With MultiPoint Pacing

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