Motor Cortex Versus Insula Stimulation Using Transcranial Current Stimulation on Chronic Post-mastectomy Pain
Post-Mastectomy Chronic Pain Syndrome
About this trial
This is an interventional supportive care trial for Post-Mastectomy Chronic Pain Syndrome
Eligibility Criteria
Inclusion Criteria:
- eighty patients within age group 18-65 years old with post mastectomy neuropathic pain that are resistant to medical treatment in the form of tramadol hydrochloride 100 mg twice daily, pregabalin 75 mg twice daily and Amitriptyline 25 mg once daily for at least two months or associated with significant adverse effect from medication will be involved in this study.
Exclusion Criteria:
- We will exclude patients with intracranial metallic devices or with pacemakers or any other device. We also exclude those with extensive myocardial ischemia and those known to have epilepsy
Sites / Locations
- South Egypt Cancer Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Sham Comparator
Active Comparator
Sham Comparator
group 1: active primary motor cortex stimulation
group 2 : sham primary motor cortex stimulation
group 3 : active insula stimulation
group 4 : sham insula stimulation
active tDCS (2 mA) targeting the primary motor cortex of the contralateral side of the pain for 20 minute duration for five sessions in five consecutive days (one session /day)
sham tDCS over the primary motor cortex in the same stimulation parameters will be used but the device will be turned off without patient knowledge after 30 seconds.
active tDCS (2 mA) targeting the insula of the contralateral side of the pain for 20 minute duration for five sessions in five consecutive days (one session /day)
sham tDCS over the insula in the same stimulation parameters will be used but the device will be turned off without patient knowledge after 30 seconds.