MR Imaging- Guided High Intensity Focused Ultrasound (HIFU) Therapy of Bone Metastases
Bone Metastases, Bone Neoplasm, Bone Cancer
About this trial
This is an interventional supportive care trial for Bone Metastases focused on measuring HIFU, MR-HIFU, MRgFUs, MRI-intervention, Palliation
Eligibility Criteria
Inclusion criteria
- Bone metastasis
- Maximum three metastasis to be treated
- Pain that clearly locates to certain metastatic lesion
- Intolerable pain regardless of radiotherapy and adequate pain medication
Exclusion criteria from HIFU-treatment group
- ASA-group III or higher or anesthesia during procedure is required
- Metastasis not safely reachable with HIFU
Exclusion criteria from the study
- Diffusely spread metastasis on bone
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
HIFU-treatment
Radiation therapy
Pre-treatment imaging Pre-treatment questionnaires and laboratory blood samples Intervention (Thermal ablation of bone metastasis with MR-HIFU device Philips Sonalleve coupled with Philips Ingenia 3.0T) Follow-up (imaging, questionnaires, laboratory) Follow-up pain medication usage
Pre-treatment imaging Pre-treatment questionnaires and laboratory blood samples Intervention (Varian Truebeam Radiotherapy System) Follow-up (imaging, questionnaires, laboratory) Follow-up pain medication usage