Back to resultsMultiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed
Primary Purpose
Cognitive Decline, Aging
Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Resistance exercise
Stretching exercise (sham exercise)
Sponsored by
About this trial
This is an interventional other trial for Cognitive Decline focused on measuring exercise, resistance training, kinesiology, cognition, ERP, neuroimage
Eligibility Criteria
Inclusion Criteria:
- male adults aged 50-65 years old
- exercise ≥ 150 minutes/week
- normal or corrected-to-normal vision
- right-handed
Exclusion Criteria:
- dementia (MMSE ≥ 24)
- any medical condition listed on PARQ
- depression (BDI-II score ≤ 13)
- any diagnostic cardiovascular, neurological and other chronic diseases
Sites / Locations
- National Taiwan Normal University
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Resistance exercise
Stretching exercise
Arm Description
The experimental intervention is a session of resistance exercise described in the intervention section.
The active control intervention is a session of stretching exercise described in the intervention section.
Outcomes
Primary Outcome Measures
Change of Information processing speed between resistance and stretching exercises
Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.
Change of Inhibitory control between resistance and stretching exercises
Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.
Secondary Outcome Measures
Change of Conflict-related neural activity between resistance and stretching exercises
N2b (event-related potential)
Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises
P3 (event-related potential)
Full Information
NCT ID
NCT04534374
First Posted
August 25, 2020
Last Updated
August 27, 2020
Sponsor
National Taiwan Normal University
1. Study Identification
Unique Protocol Identification Number
NCT04534374
Brief Title
Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed
Official Title
Acute Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed and Decreases Conflict-related Neural Activity in Older Adults: A Crossover, Sham Control, Randomized Control Trial With REP
Study Type
Interventional
2. Study Status
Record Verification Date
August 2020
Overall Recruitment Status
Completed
Study Start Date
August 1, 2017 (Actual)
Primary Completion Date
August 1, 2019 (Actual)
Study Completion Date
August 1, 2019 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
National Taiwan Normal University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cognitive Decline, Aging
Keywords
exercise, resistance training, kinesiology, cognition, ERP, neuroimage
7. Study Design
Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
Participant
Allocation
Randomized
Enrollment
28 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Resistance exercise
Arm Type
Experimental
Arm Description
The experimental intervention is a session of resistance exercise described in the intervention section.
Arm Title
Stretching exercise
Arm Type
Active Comparator
Arm Description
The active control intervention is a session of stretching exercise described in the intervention section.
Intervention Type
Behavioral
Intervention Name(s)
Resistance exercise
Intervention Description
Barbell back squat, press, and deadlift for three sets of five repetitions with the weight closest to 75% of their estimated 1 repetition max. The participants were instructed to execute the movement with moderate speed (2s eccentric, 2s concentric, no pause in between). The rest period between sets and exercise movements was two to three minutes.
Intervention Type
Behavioral
Intervention Name(s)
Stretching exercise (sham exercise)
Intervention Description
Participants completed a passive stretching exercise session for a similar duration of time as the resistance exercise (≈ 30 min) as sham intervention, which included 15-20 stretching movements twice, holding each for 30 seconds as recommended by ACSM.
Primary Outcome Measure Information:
Title
Change of Information processing speed between resistance and stretching exercises
Description
Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.
Time Frame
5-30 minutes before and 10-35 minutes after each intervention.
Title
Change of Inhibitory control between resistance and stretching exercises
Description
Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.
Time Frame
5-30 minutes before and 10-35 minutes after each intervention.
Secondary Outcome Measure Information:
Title
Change of Conflict-related neural activity between resistance and stretching exercises
Description
N2b (event-related potential)
Time Frame
5-30 minutes before and 10-35 minutes after each intervention.
Title
Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises
Description
P3 (event-related potential)
Time Frame
5-30 minutes before and 10-35 minutes after each intervention.
10. Eligibility
Sex
Male
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
male adults aged 50-65 years old
exercise ≥ 150 minutes/week
normal or corrected-to-normal vision
right-handed
Exclusion Criteria:
dementia (MMSE ≥ 24)
any medical condition listed on PARQ
depression (BDI-II score ≤ 13)
any diagnostic cardiovascular, neurological and other chronic diseases
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Tsung-Min Hung, Ph.D.
Organizational Affiliation
Department of Physical Education, National Taiwan Normal University
Official's Role
Study Chair
Facility Information:
Facility Name
National Taiwan Normal University
City
Taipei
Country
Taiwan
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
The participant-level data and statistical code are available on request and the data will be anonymized.
IPD Sharing Time Frame
Three years within the publication.
Citations:
PubMed Identifier
33911153
Citation
Lin TY, Hsieh SS, Chueh TY, Huang CJ, Hung TM. The effects of barbell resistance exercise on information processing speed and conflict-related ERP in older adults: a crossover randomized controlled trial. Sci Rep. 2021 Apr 28;11(1):9137. doi: 10.1038/s41598-021-88634-5.
Results Reference
derived
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Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed
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