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Nab-paclitaxel and Gemcitabine vs Gemcitabine Alone as Adjuvant Therapy for Patients With Resected Pancreatic Cancer (the "Apact" Study) (apact)

Primary Purpose

Pancreatic Neoplasms, Digestive System Neoplasms, Neoplasms by Site

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
nab-Paclitaxel
Gemcitabine
Sponsored by
Celgene
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Pancreatic Neoplasms focused on measuring Resectable pancreatic cancer, resected, resectable PDA, adenocarcinoma, surgically resected, adjuvant, Abraxane, nab-paclitaxel, ABI-007, gemcitabine, Gemzar, Phase 3

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Histologically confirmed resected ductal pancreatic adenocarcinoma with macroscopic complete resection (R0 and R1). Subjects with neuroendocrine (and mixed type) tumors are excluded.
  2. Pancreatic cancer surgical staging: Tumor (T) 1-3, Lymph Node (LN) N0-1, Metastasis (M) 0.
  3. Subject should be able to start treatment no later than 12 weeks postsurgery.
  4. ≥18 years of age at the time of signing the informed consent form (ICF).
  5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

  6. Acceptable hematology parameters:

    • Absolute neutrophil count (ANC) ≥1500 cell/mm^3
    • Platelet count ≥100,000/mm^3
    • Hemoglobin (Hgb) ≥9 g/dL

  7. Acceptable blood chemistry levels:

    • Aspartate aminotransferase (AST)/ serum glutamic oxaloacetic transaminase (SGOT) and alanine transaminase (ALT)/ serum glutamic -pyruvic transaminase (SGPT) ≤2.5 × upper limit of normal range (ULN)
    • Total bilirubin ≤ upper limit of normal (participants with Gilbert's syndrome can have bilirubin of up to 1.5 x ULN)
    • Alkaline phosphatase ≤ 2.5 x ULN
    • Serum creatinine within upper limits of normal or calculated clearance ≥50 mL/min/1.73 m^2. If using creatinine clearance, actual body weight should be used for calculating creatinine clearance (eg, using the Cockroft-Gault formula). For subjects with a body mass index (BMI) >30 kg/m2, lean body weight should be used instead
  8. Cancer antigen (CA)19-9 <100 U/mL assessed within 14 days of randomization
  9. Acceptable coagulation studies as demonstrated by prothrombin time (PT) and partial thromboplastin time (PTT) within normal limits (±15%)

Exclusion Criteria:

A subject will not be eligible for inclusion in this study if any of the following criteria apply:

  1. Prior neo-adjuvant treatment or radiation therapy for pancreatic adenocarcinoma
  2. Presence of or history of metastatic pancreatic adenocarcinoma
  3. Any other malignancy within 5 years prior to randomization, with the exception of adequately treated in-situ carcinoma of the cervix, uteri, or nonmelanomatous skin cancer (all treatment of which should have been completed 6 months prior to randomization)
  4. Active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy, defined as ongoing signs/symptoms related to the infection without improvement despite appropriate antibiotics, antiviral therapy, and/or other treatment
  5. Known infection with hepatitis B or C, or history of human immunodeficiency virus (HIV) infection, or subject receiving immunosuppressive or myelosuppressive medications that would in the opinion of the investigator, increase the risk of serious neutropenic complications
  6. History of allergy or hypersensitivity to nab-paclitaxel or gemcitabine or any of their excipients

  7. Serious medical risk factors involving any of the major organ systems, or serious psychiatric disorders, which could compromise the subject's safety or the study data integrity. These include, but are not limited to:

    1. History of connective tissue disorders (eg, lupus, scleroderma, arteritis nodosa)
    2. History of interstitial lung disease, slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies
    3. History of the following within 6 months prior to Cycle 1 Day 1: a myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, New York Heart Association (NYHA) Class III-IV heart failure, uncontrolled hypertension, clinically significant cardiac dysrhythmia or electrocardiogram (ECG) abnormality, cerebrovascular accident, transient ischemic attack, or seizure disorder

Sites / Locations

  • Local Institution - 043
  • Mayo Clinic - Arizona
  • UCSD Moores Cancer Center
  • University of Southern California
  • Local Institution - 044
  • UC Davis Cancer Center
  • Local Institution - 001
  • University of California, San Francisco Cutaneous Oncology and Melanoma Center
  • University of California Los Angeles
  • University of Colorado Cancer Center
  • Local Institution - 059
  • Rocky Mountain Cancer Centers, LLP [Denver-Midtown]
  • Yale Cancer Center
  • Local Institution - 022
  • Lynn Cancer Institute
  • Florida Cancer Institute Cancer Spec
  • Local Institution - 031
  • Gainesville Heme Oncology Associates
  • Local Institution - 011
  • University of Florida
  • University of Miami and Sylvester Cancer Center
  • Florida Hospital Cancer Institute
  • Local Institution - 039
  • H Lee Moffitt Cancer Center
  • Georgia Cancer Specialist
  • University of Chicago Medical Center
  • Northshore University Healthsystem Research Institute
  • Illinois Cancer Specialists
  • University of Louisville
  • Ochsner Clinic Foundation
  • Ochsner Medical Center - Jefferson Highway
  • Massachusetts General Hospital
  • Beth Israel-Deaconess Medical Center
  • Local Institution - 040
  • Dana Farber Cancer Institute
  • Local Institution - 045
  • Local Institution - 036
  • University of Michigan
  • Karmanos Cancer Center Wayne State University
  • Local Institution - 021
  • Mayo Clinic
  • Local Institution - 048
  • Nebraska Methodist Hospital
  • Local Institution - 064
  • MSKCC Basking Ridge
  • Saint Barnabas Medical Center
  • Local Institution - 025
  • Roswell Park Cancer Institute
  • Memorial Sloan-Kettering Cancer Center
  • Memorial Sloan Kettering Cancer Center West Harrison
  • NYU Langone Medical Center
  • Local Institution - 008
  • Memorial Sloan-Kettering Cancer Center - NYC
  • Columbia University Medical Center
  • Local Institution - 032
  • Local Institution - 013
  • University of Rochester Cancer Center, James P. Wilmot Cancer Center
  • Local Institution - 066
  • MSKCC at Mercy Medical Center Mercy RockvilleCenter
  • MSKCC at Phelps Memorial Hospital Center. Phelps Sleepy Hollow
  • State University of New York Upstate Medical Center
  • Local Institution - 051
  • Wake Forest Univ. Health Sciences Outpatient Comprehensive Cancer Center
  • Local Institution - 030
  • Oncology Hematology Care, Inc.
  • University of Cincinnati Medical CenterDivsion of Hematology OncologyThe Barrett Center
  • Case Western Reserve Center
  • Local Institution - 047
  • Cleveland Clinic - Taussig Cancer Institute
  • Cleveland Clinic Foundation IRB
  • Cleveland Clinic Foundation
  • Local Institution - 020
  • Local Institution - 054
  • Local Institution - 005
  • Ohio State University Medical Center
  • Local Institution - 049
  • University of Oklahoma Peggy and Charles Stephenson Cancer Center
  • Local Institution - 019
  • Oregon Health and Science University OHSU
  • Local Institution - 016
  • Thomas Jefferson University
  • Fox Chase Cancer Center
  • Local Institution - 027
  • UPMC Cancer Pavillion
  • Chattanooga Oncology Hematology Care
  • Local Institution - 023
  • Local Institution - 004
  • Sarah Cannon Research Inst
  • Local Institution - 002
  • Vanderbilt- Ingram Cancer Center
  • Texas Oncology
  • Baylor Sammons Cancer Center
  • Local Institution - 062
  • Local Institution - 010
  • UT Southwestern Medical Center
  • Local Institution - 050
  • The Center for Cancer and Blood Disorders - Fort Worth
  • Baylor College of Medicine
  • Local Institution - 041
  • Texas Oncology, P.A. - Tyler
  • Local Institution - 038
  • University of Virginia
  • Local Institution - 003
  • Seattle Cancer Care Alliance - Seattle
  • Virginia Mason Cancer Center
  • Local Institution - 014
  • University of Wisconsin - Madison Cancer Center
  • Canberra Hospital
  • Local Institution - 505
  • Local Institution - 501
  • Local Institution - 507
  • Northern Cancer Institute
  • Local Institution - 504
  • ICON Cancer Center
  • Local Institution - 502
  • Local Institution - 506
  • Local Institution - 508
  • St John of God Subiaco Hospital
  • Monash Medical Centre Moorabbin Campus
  • Saint Vincent's Hospital
  • Austin Hospital
  • Local Institution - 509
  • Royal Brisbane and Women's Hospital
  • Cabrini Hospital
  • Local Institution - 503
  • Local Institution - 500
  • Prince of Wales Hospital
  • The Queen Elizabeth Hospital
  • Local Institution - 205
  • Medical University of Graz
  • Local Institution - 203
  • Medical University Innsbruck
  • Hospital of Elisabethinen Linz
  • Local Institution - 206
  • Local Institution - 204
  • Salzburger Landkliniken St. Johanns-Spital
  • Klinikum Wels-Grieskirchen GmbH
  • Local Institution - 0207
  • Hospital Wiener Neustadt
  • Local Institution - 202
  • Local Institution - 200
  • Medizinische Universitat Wien
  • Kaiser-Franz-Josef Spital
  • Local Institution - 201
  • Hopital Erasme
  • Local Institution - 211
  • UZ Antwerpen
  • Local Institution - 213
  • UZ Gent
  • Local Institution - 210
  • UZ Leuven
  • Local Institution - 102
  • Tom Baker Cancer Center
  • Local Institution - 101
  • Sunnybrook Health Sciences Centre
  • Local Institution - 100
  • Princess Margaret Hospital
  • Centre Hospitalier de L'Universite de Montreal St-Luc
  • Local Institution - 104
  • Jewish General Hospital
  • Local Institution - 103
  • Fakultni nemocnice Hradec Kralove
  • Local Institution - 220
  • Krajska nemocnice Liberec, a.s.
  • Krajska nemocnice T. Bati a.s.
  • Local Institution - 221
  • Hæmatologisk afd. B Aalborg Sygehus Syd
  • Local Institution - 231
  • Herlev Hospital
  • Local Institution - 232
  • Local Institution - 230
  • Onk.Dep., Odense Universitets hospital
  • Local Institution - 240
  • Helsingin yliopistollinen keskussairaala
  • Local Institution - 241
  • Tampereen yliopistollinen sairaala
  • Local Institution - 242
  • Turku University Hospital
  • Center Hospitalier Universitaire d' Angers
  • Local Institution - 253
  • Hopital Henri Mondor
  • CHRU de Lille France
  • Local Institution - 257
  • Hopital Edouard Herriot - Hepato-gastroenterologie
  • Local Institution - 258
  • Hopital prive Jean Mermoz
  • Local Institution - 252
  • Hopital Europeen Georges Pompidou
  • Local Institution - 250
  • Hopital Saint Antoine
  • Hopital Pitie Salpetriere
  • Local Institution - 259
  • CHU La Miletrie
  • Local Institution - 251
  • Local Institution - 256
  • Pole Des Specialites Medicales, Hopital Purpan
  • Klinikum Weiden
  • Local Institution - 280
  • Charite - Universitätsmedizin Berlin
  • Local Institution - 272
  • Local Institution - 278
  • Universitatsklinikum Carl Gustav Carus an der TU Dresden
  • Kliniken Essen-Mitte
  • Local Institution - 277
  • Universitatsklinkum Frankfurt
  • Local Institution - 284
  • Praxis Internistischer Onkologie und Hamatologie Frechen
  • Local Institution - 275
  • Praxis für Innere Medizin, Dr.Oettle Helmut
  • Ernst-Moritz-Arndt-Universität Greifswald
  • Local Institution - 279
  • Local Institution - 273
  • Universitaetsklinik Hamburg - Eppendorf
  • Local Institution - 281
  • Praxis Internistischer Onkologie und Hamatologie Koln
  • Local Institution - 274
  • Universitatsklinik Magdeburg
  • Klinikum der Johannes Gutenberg Uniervsitaet ,Haematologie
  • Local Institution - 283
  • Klinikum der Universitat Munchen-Grosshadern
  • Local Institution - 282
  • Klinikum Neuperlach
  • Local Institution - 276
  • Local Institution - 0271
  • University of Tubingen
  • Local Institution - 270
  • Universitatsklinikum Würzburg
  • Local Institution - 601
  • Queen Mary Hospital
  • Tuen Mun Hospital
  • Local Institution - 602
  • Prince of Wales Hospital the Chinese University of Hong Kong
  • Fovarosi Szent Istvan es Szent Laszlo Korhaz es Rendelointezet
  • Local Institution - 293
  • Local Institution - 291
  • Uzsoki Utcai Korhaz
  • Debreceni Egyetem Orvos- es Egeszsegtudomanyi Centrum
  • Local Institution - 290
  • Local Institution - 292
  • Petz Aladar Megyei Oktato Korhaz,II. Belgyogyaszat
  • Local Institution - 295
  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Szent-Gyorgyi Albert TE AOK Borgyogy
  • Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
  • Local Institution - 311
  • Cork University Hospital
  • Local Institution - 310
  • St Vincent's University Hospital
  • Local Institution - 329
  • Local Institution - 325
  • Ospedali Riuniti Umberto I GM Lancisi
  • Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi
  • Local Institution - 330
  • Azienda Ospedaliero-Universitaria Careggi
  • Local Institution - 328
  • Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori (I.R.S.T.)
  • Local Institution - 331
  • Local Institution - 321
  • Ospedale San Raffaele S.r.l.
  • Azienda Ospedaliera Niguarda Ca Granda
  • Local Institution - 322
  • Azienda Ospedaliero-Universitaria Pisana
  • Local Institution - 324
  • Arcispedale Santa Maria Nuova
  • Local Institution - 333
  • Local Institution - 323
  • Local Institution - 327
  • Policlinico Universitario Agostino Gemelli
  • Istituto Nazionale Tumori Regina Elena
  • Istituto Clinico Humanitas
  • Local Institution - 326
  • IRCCS Casa Sollievo della Sofferenza
  • Local Institution - 332
  • Azienda Ospedaliera S Maria di Terni
  • Azienda Ospedaliera Universitaria Integrata di Verona
  • Local Institution - 320
  • Local Institution - 641
  • Seoul National University Hospital
  • Local Institution - 642
  • Samsung Medical Center
  • Asan Medical Center
  • Local Institution - 640
  • Academisch Medisch Centrum Amsterdam
  • Local Institution - 400
  • Catharina Hospital
  • Local Institution - 403
  • Isala Klinieken
  • Local Institution - 402
  • Centro Hospitalar de Lisboa Central - Hospital de Santo António dos Capuchos
  • Local Institution - 340
  • Hospital Da Luz
  • Local Institution - 341
  • Hospital de Sao Joao
  • Local Institution - 342
  • Local Institution - 610
  • National University Hospital
  • Local Institution - 611
  • National Cancer Center
  • Local Institution - 371
  • Local Institution - 360
  • Clinic Barcelona Hospital Universitari
  • Local Institution - 363
  • Instituto Catalan de Oncologia-Hospital Duran
  • Local Institution - 370
  • Hospital Universitari Vall d'Hebron
  • Hospital General Gregorio Maranon
  • Local Institution - 367
  • Local Institution - 362
  • Ramon y Cajal Univeresity Hospital
  • Hospital Clinico San Carlos
  • Local Institution - 372
  • Hospital 12 de Octubre
  • Local Institution - 365
  • Centro Integral
  • Local Institution - 361
  • Hospital General Carlos Haya
  • Local Institution - 369
  • Complejo Hospitalario de Navarra
  • Local Institution - 368
  • Hospital Universitario Marques de Valdecilla
  • Hospital Clinico Universitario De Santiago De Compostela
  • Local Institution - 366
  • Hospital Virgen del Rocio
  • Local Institution - 364
  • Local Institution - 620
  • Taichung Veterans General Hospital
  • Local Institution - 625
  • National Cheng Kung University Hospital
  • Local Institution - 623
  • Taipei Veterans General Hospital
  • Tri-Service General Hospital
  • Local Institution - 622
  • Chang Gung Medical Foundation-Linkou Branch
  • Local Institution - 624
  • Local Institution - 621
  • National Taiwan University Hospital
  • Addenbrookes Hospital
  • Local Institution - 382
  • Glasgow Royal Infirmary
  • Local Institution - 380
  • Weston Park Hospital
  • Local Institution - 381

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

nab-Paclitaxel 125 mg/m^2 plus gemcitabine 1000 mg/m2

Gemcitabine 1000 mg/m^2

Arm Description

Participants received nab-Paclitaxel 125 mg/m^2 administered as an intravenous (IV) infusion over 30 to 40 minutes, followed by gemcitabine 1000 mg/m^2 as an IV infusion over 30 to 40 minutes on Days 1, 8 and 15 of each 28-day treatment cycle for 6 cycles, unless there was evidence of radiologic disease recurrence, unacceptable toxicity, subject or physician decision, withdrawal of consent, or death.

Participants received gemcitabine 1000 mg/m^2 administered as an IV infusion over 30 to 40 minutes on Days 1, 8 and 15 of each 28-day treatment cycle for 6 cycles, unless there was evidence of radiologic disease recurrence, unacceptable toxicity, subject or physician decision, withdrawal of consent, or death.

Outcomes

Primary Outcome Measures

Kaplan Meier Estimate for Disease Free Survival (DFS) According to the Independent Radiological Review Committee
Disease free survival was defined as the time from the date of randomization to the date of disease recurrence or death, whichever occurred earlier. Disease recurrence was determined by the independent radiological review of computed tomography (CT) or magnetic resonance imaging (MRI) scans. Participants who did not have disease recurrence or did not die were censored at the last tumor assessment date with disease-free status or the randomization date if the last tumor assessment with disease-free status was missing. Disease-free status referred to a status that was neither being disease recurrent nor indeterminate or not evaluable. Participants who received new anti-cancer therapy or cancer-related surgery prior to disease recurrence or death were censored at the date of last tumor assessment with disease-free status prior to the start of new anti-cancer therapy or cancer-related surgery or the randomization date.

Secondary Outcome Measures

Kaplan Meier Estimate of Overall Survival (OS)
Overall survival was defined as the time from the date of randomization to the date of death. Participants who were alive at the end of study or clinical data cut were censored on the last-known-to-be-alive date or the clinical cutoff date, whichever was earlier.
Number of Participants With Treatment Emergent Adverse Events (TEAE's)
TEAEs are defined as any adverse event (AE) that begin or worsen on or after the start of study drug or procedure of the study period through the maximum duration of the period plus 28 days. The severity of AEs was graded based on National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), Version 4.0 and the scale: Grade 1 = Mild Grade 2 = Moderate Grade 3 = Severe Grade 4 = Life threatening Grade 5 = Death. Relation to study drug was determined by the investigator. A treatment-related TEAE is defined as TEAE which was considered to be related to one or both of the study drugs and reported as 'Suspected' on the case report form. AEs with a missing relationship were treated as 'treatment-related' in data summaries. IP (investigational product) refers to nab-Paclitaxel and/or Gemcitabine. "Related" TEAE refers to relation to study drug (IP).
The Number of Participants With Clinical Chemistry Laboratory-Detected Abnormalities (Grade 3-4)
The number of participants with grade 3-4 laboratory abnormalities in selected clinically significant parameters. Grades for chemistry parameters were coded using National Cancer Institute Common Terminology Criteria for Adverse Events (Grade 3= severe, Grade 4= life-threatening).

Full Information

First Posted
October 14, 2013
Last Updated
June 13, 2023
Sponsor
Celgene
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1. Study Identification

Unique Protocol Identification Number
NCT01964430
Brief Title
Nab-paclitaxel and Gemcitabine vs Gemcitabine Alone as Adjuvant Therapy for Patients With Resected Pancreatic Cancer (the "Apact" Study)
Acronym
apact
Official Title
A Phase 3, Multicenter, Open-label, Randomized Study of Nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Subjects With Surgically Resected Pancreatic Adenocarcinoma
Study Type
Interventional

2. Study Status

Record Verification Date
June 2023
Overall Recruitment Status
Completed
Study Start Date
March 28, 2014 (Actual)
Primary Completion Date
June 30, 2022 (Actual)
Study Completion Date
June 30, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Celgene

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to compare whether there is a delay or prevention of recurrence or death in participants with surgically removed pancreatic cancer who then take nab-Paclitaxel in combination with gemcitabine compared to those who take gemcitabine alone.
Detailed Description
ABI-007-PANC-003 is a Phase 3, international, multicenter, randomized, open-label, controlled study that will compare the efficacy of nab-paclitaxel in combination with gemcitabine to gemcitabine alone as adjuvant treatment for 6 cycles in patients with surgically resected pancreatic adenocarcinoma.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pancreatic Neoplasms, Digestive System Neoplasms, Neoplasms by Site, Neoplasms, Endocrine Gland Neoplasms, Pancreatic Diseases, Digestive System Diseases, Endocrine System Diseases, Gemcitabine, Antimetabolites, Antineoplastic
Keywords
Resectable pancreatic cancer, resected, resectable PDA, adenocarcinoma, surgically resected, adjuvant, Abraxane, nab-paclitaxel, ABI-007, gemcitabine, Gemzar, Phase 3

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
866 (Actual)

8. Arms, Groups, and Interventions

Arm Title
nab-Paclitaxel 125 mg/m^2 plus gemcitabine 1000 mg/m2
Arm Type
Experimental
Arm Description
Participants received nab-Paclitaxel 125 mg/m^2 administered as an intravenous (IV) infusion over 30 to 40 minutes, followed by gemcitabine 1000 mg/m^2 as an IV infusion over 30 to 40 minutes on Days 1, 8 and 15 of each 28-day treatment cycle for 6 cycles, unless there was evidence of radiologic disease recurrence, unacceptable toxicity, subject or physician decision, withdrawal of consent, or death.
Arm Title
Gemcitabine 1000 mg/m^2
Arm Type
Active Comparator
Arm Description
Participants received gemcitabine 1000 mg/m^2 administered as an IV infusion over 30 to 40 minutes on Days 1, 8 and 15 of each 28-day treatment cycle for 6 cycles, unless there was evidence of radiologic disease recurrence, unacceptable toxicity, subject or physician decision, withdrawal of consent, or death.
Intervention Type
Drug
Intervention Name(s)
nab-Paclitaxel
Other Intervention Name(s)
Abraxane
Intervention Description
nab-Paclitaxel 125 mg/m^2 on Days 1, 8, and 15 of every 28 day treatment cycle by intravenous (IV) administration for a total of 6 cycles.
Intervention Type
Drug
Intervention Name(s)
Gemcitabine
Other Intervention Name(s)
Gemzar
Intervention Description
Gemcitabine 1000 mg/m^2 on Days 1, 8, and 15 of a 28 day cycle by IV administration for a total of 6 cycles.
Primary Outcome Measure Information:
Title
Kaplan Meier Estimate for Disease Free Survival (DFS) According to the Independent Radiological Review Committee
Description
Disease free survival was defined as the time from the date of randomization to the date of disease recurrence or death, whichever occurred earlier. Disease recurrence was determined by the independent radiological review of computed tomography (CT) or magnetic resonance imaging (MRI) scans. Participants who did not have disease recurrence or did not die were censored at the last tumor assessment date with disease-free status or the randomization date if the last tumor assessment with disease-free status was missing. Disease-free status referred to a status that was neither being disease recurrent nor indeterminate or not evaluable. Participants who received new anti-cancer therapy or cancer-related surgery prior to disease recurrence or death were censored at the date of last tumor assessment with disease-free status prior to the start of new anti-cancer therapy or cancer-related surgery or the randomization date.
Time Frame
Date of randomization up to data cut off date of 31 December 2018; median DFS follow-up time for censored participants was 22.242 months for nab-Paclitaxel and gemcitabine and 13.832 months for gemcitabine alone
Secondary Outcome Measure Information:
Title
Kaplan Meier Estimate of Overall Survival (OS)
Description
Overall survival was defined as the time from the date of randomization to the date of death. Participants who were alive at the end of study or clinical data cut were censored on the last-known-to-be-alive date or the clinical cutoff date, whichever was earlier.
Time Frame
From randomization to date of death; median OS follow-up time for censored participants was 77.832 months for nab-Paclitaxel and gemcitabine and 77.799 months for gemcitabine alone
Title
Number of Participants With Treatment Emergent Adverse Events (TEAE's)
Description
TEAEs are defined as any adverse event (AE) that begin or worsen on or after the start of study drug or procedure of the study period through the maximum duration of the period plus 28 days. The severity of AEs was graded based on National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), Version 4.0 and the scale: Grade 1 = Mild Grade 2 = Moderate Grade 3 = Severe Grade 4 = Life threatening Grade 5 = Death. Relation to study drug was determined by the investigator. A treatment-related TEAE is defined as TEAE which was considered to be related to one or both of the study drugs and reported as 'Suspected' on the case report form. AEs with a missing relationship were treated as 'treatment-related' in data summaries. IP (investigational product) refers to nab-Paclitaxel and/or Gemcitabine. "Related" TEAE refers to relation to study drug (IP).
Time Frame
From day 1 of study drug up to 28 days after the last dose of study drug; up to the data cut off date of 31 December 2018 (up to approximately 37 weeks).
Title
The Number of Participants With Clinical Chemistry Laboratory-Detected Abnormalities (Grade 3-4)
Description
The number of participants with grade 3-4 laboratory abnormalities in selected clinically significant parameters. Grades for chemistry parameters were coded using National Cancer Institute Common Terminology Criteria for Adverse Events (Grade 3= severe, Grade 4= life-threatening).
Time Frame
From day 1 of study drug up to 28 days after the last dose of study drug, or the treatment discontinuation date, whichever was later (up to approximately 37 weeks).

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Histologically confirmed resected ductal pancreatic adenocarcinoma with macroscopic complete resection (R0 and R1). Subjects with neuroendocrine (and mixed type) tumors are excluded. Pancreatic cancer surgical staging: Tumor (T) 1-3, Lymph Node (LN) N0-1, Metastasis (M) 0. Subject should be able to start treatment no later than 12 weeks postsurgery. ≥18 years of age at the time of signing the informed consent form (ICF). Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Acceptable hematology parameters: Absolute neutrophil count (ANC) ≥1500 cell/mm^3 Platelet count ≥100,000/mm^3 Hemoglobin (Hgb) ≥9 g/dL Acceptable blood chemistry levels: Aspartate aminotransferase (AST)/ serum glutamic oxaloacetic transaminase (SGOT) and alanine transaminase (ALT)/ serum glutamic -pyruvic transaminase (SGPT) ≤2.5 × upper limit of normal range (ULN) Total bilirubin ≤ upper limit of normal (participants with Gilbert's syndrome can have bilirubin of up to 1.5 x ULN) Alkaline phosphatase ≤ 2.5 x ULN Serum creatinine within upper limits of normal or calculated clearance ≥50 mL/min/1.73 m^2. If using creatinine clearance, actual body weight should be used for calculating creatinine clearance (eg, using the Cockroft-Gault formula). For subjects with a body mass index (BMI) >30 kg/m2, lean body weight should be used instead Cancer antigen (CA)19-9 <100 U/mL assessed within 14 days of randomization Acceptable coagulation studies as demonstrated by prothrombin time (PT) and partial thromboplastin time (PTT) within normal limits (±15%) Exclusion Criteria: A subject will not be eligible for inclusion in this study if any of the following criteria apply: Prior neo-adjuvant treatment or radiation therapy for pancreatic adenocarcinoma Presence of or history of metastatic pancreatic adenocarcinoma Any other malignancy within 5 years prior to randomization, with the exception of adequately treated in-situ carcinoma of the cervix, uteri, or nonmelanomatous skin cancer (all treatment of which should have been completed 6 months prior to randomization) Active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy, defined as ongoing signs/symptoms related to the infection without improvement despite appropriate antibiotics, antiviral therapy, and/or other treatment Known infection with hepatitis B or C, or history of human immunodeficiency virus (HIV) infection, or subject receiving immunosuppressive or myelosuppressive medications that would in the opinion of the investigator, increase the risk of serious neutropenic complications History of allergy or hypersensitivity to nab-paclitaxel or gemcitabine or any of their excipients Serious medical risk factors involving any of the major organ systems, or serious psychiatric disorders, which could compromise the subject's safety or the study data integrity. These include, but are not limited to: History of connective tissue disorders (eg, lupus, scleroderma, arteritis nodosa) History of interstitial lung disease, slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies History of the following within 6 months prior to Cycle 1 Day 1: a myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, New York Heart Association (NYHA) Class III-IV heart failure, uncontrolled hypertension, clinically significant cardiac dysrhythmia or electrocardiogram (ECG) abnormality, cerebrovascular accident, transient ischemic attack, or seizure disorder
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bristol-Myers Squibb
Organizational Affiliation
Bristol-Myers Squibb
Official's Role
Study Director
Facility Information:
Facility Name
Local Institution - 043
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85259
Country
United States
Facility Name
Mayo Clinic - Arizona
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85259
Country
United States
Facility Name
UCSD Moores Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
University of Southern California
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Local Institution - 044
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
UC Davis Cancer Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
Local Institution - 001
City
San Francisco
State/Province
California
ZIP/Postal Code
94110
Country
United States
Facility Name
University of California, San Francisco Cutaneous Oncology and Melanoma Center
City
San Francisco
State/Province
California
ZIP/Postal Code
9411
Country
United States
Facility Name
University of California Los Angeles
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Facility Name
University of Colorado Cancer Center
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Local Institution - 059
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
Rocky Mountain Cancer Centers, LLP [Denver-Midtown]
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
Yale Cancer Center
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Local Institution - 022
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33486
Country
United States
Facility Name
Lynn Cancer Institute
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33486
Country
United States
Facility Name
Florida Cancer Institute Cancer Spec
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33916
Country
United States
Facility Name
Local Institution - 031
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33916
Country
United States
Facility Name
Gainesville Heme Oncology Associates
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32605
Country
United States
Facility Name
Local Institution - 011
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32610
Country
United States
Facility Name
University of Florida
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32610
Country
United States
Facility Name
University of Miami and Sylvester Cancer Center
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Florida Hospital Cancer Institute
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Facility Name
Local Institution - 039
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Facility Name
H Lee Moffitt Cancer Center
City
Tampa
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Facility Name
Georgia Cancer Specialist
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30341
Country
United States
Facility Name
University of Chicago Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Northshore University Healthsystem Research Institute
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Facility Name
Illinois Cancer Specialists
City
Niles
State/Province
Illinois
ZIP/Postal Code
60714
Country
United States
Facility Name
University of Louisville
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Ochsner Clinic Foundation
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121-2483
Country
United States
Facility Name
Ochsner Medical Center - Jefferson Highway
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121-2483
Country
United States
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Beth Israel-Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
Local Institution - 040
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
Dana Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Local Institution - 045
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Local Institution - 036
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
University of Michigan
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Karmanos Cancer Center Wayne State University
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Facility Name
Local Institution - 021
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Mayo Clinic
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Local Institution - 048
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
Nebraska Methodist Hospital
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
Local Institution - 064
City
Basking Ridge
State/Province
New Jersey
ZIP/Postal Code
07920
Country
United States
Facility Name
MSKCC Basking Ridge
City
Basking Ridge
State/Province
New Jersey
ZIP/Postal Code
07920
Country
United States
Facility Name
Saint Barnabas Medical Center
City
Livingston
State/Province
New Jersey
ZIP/Postal Code
07039
Country
United States
Facility Name
Local Institution - 025
City
Buffalo
State/Province
New York
ZIP/Postal Code
14263
Country
United States
Facility Name
Roswell Park Cancer Institute
City
Buffalo
State/Province
New York
ZIP/Postal Code
14263
Country
United States
Facility Name
Memorial Sloan-Kettering Cancer Center
City
Commack
State/Province
New York
ZIP/Postal Code
11725
Country
United States
Facility Name
Memorial Sloan Kettering Cancer Center West Harrison
City
Harrison
State/Province
New York
ZIP/Postal Code
10604
Country
United States
Facility Name
NYU Langone Medical Center
City
Lake Success
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
Local Institution - 008
City
New York
State/Province
New York
ZIP/Postal Code
10021-6007
Country
United States
Facility Name
Memorial Sloan-Kettering Cancer Center - NYC
City
New York
State/Province
New York
ZIP/Postal Code
10021-6007
Country
United States
Facility Name
Columbia University Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
Local Institution - 032
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
Local Institution - 013
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Facility Name
University of Rochester Cancer Center, James P. Wilmot Cancer Center
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Facility Name
Local Institution - 066
City
Rockville Center
State/Province
New York
ZIP/Postal Code
11570
Country
United States
Facility Name
MSKCC at Mercy Medical Center Mercy RockvilleCenter
City
Rockville Center
State/Province
New York
ZIP/Postal Code
11570
Country
United States
Facility Name
MSKCC at Phelps Memorial Hospital Center. Phelps Sleepy Hollow
City
Sleepy Hollow
State/Province
New York
ZIP/Postal Code
10591
Country
United States
Facility Name
State University of New York Upstate Medical Center
City
Syracuse
State/Province
New York
ZIP/Postal Code
13215
Country
United States
Facility Name
Local Institution - 051
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1082
Country
United States
Facility Name
Wake Forest Univ. Health Sciences Outpatient Comprehensive Cancer Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1082
Country
United States
Facility Name
Local Institution - 030
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
Oncology Hematology Care, Inc.
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
University of Cincinnati Medical CenterDivsion of Hematology OncologyThe Barrett Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267-0501
Country
United States
Facility Name
Case Western Reserve Center
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Local Institution - 047
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Cleveland Clinic - Taussig Cancer Institute
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Cleveland Clinic Foundation IRB
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Local Institution - 020
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Local Institution - 054
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Local Institution - 005
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Ohio State University Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Local Institution - 049
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
University of Oklahoma Peggy and Charles Stephenson Cancer Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
Local Institution - 019
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Oregon Health and Science University OHSU
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Local Institution - 016
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Thomas Jefferson University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Fox Chase Cancer Center
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19111
Country
United States
Facility Name
Local Institution - 027
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Facility Name
UPMC Cancer Pavillion
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Facility Name
Chattanooga Oncology Hematology Care
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37404
Country
United States
Facility Name
Local Institution - 023
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37404
Country
United States
Facility Name
Local Institution - 004
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Sarah Cannon Research Inst
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Local Institution - 002
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-6307
Country
United States
Facility Name
Vanderbilt- Ingram Cancer Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-6307
Country
United States
Facility Name
Texas Oncology
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Baylor Sammons Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Local Institution - 062
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Local Institution - 010
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
UT Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Local Institution - 050
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
The Center for Cancer and Blood Disorders - Fort Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Baylor College of Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Local Institution - 041
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Texas Oncology, P.A. - Tyler
City
Tyler
State/Province
Texas
ZIP/Postal Code
75702
Country
United States
Facility Name
Local Institution - 038
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
University of Virginia
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
Local Institution - 003
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Facility Name
Seattle Cancer Care Alliance - Seattle
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Facility Name
Virginia Mason Cancer Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98111
Country
United States
Facility Name
Local Institution - 014
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
University of Wisconsin - Madison Cancer Center
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
Canberra Hospital
City
Garran
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Facility Name
Local Institution - 505
City
Garran
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Facility Name
Local Institution - 501
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Local Institution - 507
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
Northern Cancer Institute
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
Local Institution - 504
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
ICON Cancer Center
City
Milton
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
Local Institution - 502
City
Milton
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
Facility Name
Local Institution - 506
City
Bentleigh East
State/Province
Victoria
ZIP/Postal Code
3165
Country
Australia
Facility Name
Local Institution - 508
City
Subiaco
State/Province
Western Australia
ZIP/Postal Code
6008
Country
Australia
Facility Name
St John of God Subiaco Hospital
City
Subiaco
State/Province
Western Australia
ZIP/Postal Code
6008
Country
Australia
Facility Name
Monash Medical Centre Moorabbin Campus
City
Bentleigh East
ZIP/Postal Code
3165
Country
Australia
Facility Name
Saint Vincent's Hospital
City
Darlinghurst
ZIP/Postal Code
2010
Country
Australia
Facility Name
Austin Hospital
City
Heidelberg
ZIP/Postal Code
3084
Country
Australia
Facility Name
Local Institution - 509
City
Heidelberg
ZIP/Postal Code
3084
Country
Australia
Facility Name
Royal Brisbane and Women's Hospital
City
Herston
ZIP/Postal Code
4029
Country
Australia
Facility Name
Cabrini Hospital
City
Malvern
ZIP/Postal Code
3144
Country
Australia
Facility Name
Local Institution - 503
City
Malvern
ZIP/Postal Code
3144
Country
Australia
Facility Name
Local Institution - 500
City
Randwick
ZIP/Postal Code
2031
Country
Australia
Facility Name
Prince of Wales Hospital
City
Randwick
ZIP/Postal Code
2031
Country
Australia
Facility Name
The Queen Elizabeth Hospital
City
Woodville South
ZIP/Postal Code
5011
Country
Australia
Facility Name
Local Institution - 205
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Medical University of Graz
City
Graz
ZIP/Postal Code
A-8036
Country
Austria
Facility Name
Local Institution - 203
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Medical University Innsbruck
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Hospital of Elisabethinen Linz
City
Linz
ZIP/Postal Code
4010
Country
Austria
Facility Name
Local Institution - 206
City
Linz
ZIP/Postal Code
4010
Country
Austria
Facility Name
Local Institution - 204
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
Salzburger Landkliniken St. Johanns-Spital
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen GmbH
City
Wels
ZIP/Postal Code
4600
Country
Austria
Facility Name
Local Institution - 0207
City
Wels
ZIP/Postal Code
4600
Country
Austria
Facility Name
Hospital Wiener Neustadt
City
Wiener Neustadt
ZIP/Postal Code
2700
Country
Austria
Facility Name
Local Institution - 202
City
Wiener Neustadt
ZIP/Postal Code
2700
Country
Austria
Facility Name
Local Institution - 200
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Medizinische Universitat Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Kaiser-Franz-Josef Spital
City
Wien
ZIP/Postal Code
1100
Country
Austria
Facility Name
Local Institution - 201
City
Wien
ZIP/Postal Code
1100
Country
Austria
Facility Name
Hopital Erasme
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
Local Institution - 211
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
UZ Antwerpen
City
Edegem
ZIP/Postal Code
2650
Country
Belgium
Facility Name
Local Institution - 213
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
UZ Gent
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Local Institution - 210
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
UZ Leuven
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Local Institution - 102
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Facility Name
Tom Baker Cancer Center
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Facility Name
Local Institution - 101
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Sunnybrook Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Local Institution - 100
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2M9
Country
Canada
Facility Name
Princess Margaret Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2M9
Country
Canada
Facility Name
Centre Hospitalier de L'Universite de Montreal St-Luc
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 3J4
Country
Canada
Facility Name
Local Institution - 104
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 3J4
Country
Canada
Facility Name
Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Local Institution - 103
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Fakultni nemocnice Hradec Kralove
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Local Institution - 220
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Krajska nemocnice Liberec, a.s.
City
Liberec
ZIP/Postal Code
460 63
Country
Czechia
Facility Name
Krajska nemocnice T. Bati a.s.
City
Zlin
ZIP/Postal Code
762 75
Country
Czechia
Facility Name
Local Institution - 221
City
Zlin
ZIP/Postal Code
762 75
Country
Czechia
Facility Name
Hæmatologisk afd. B Aalborg Sygehus Syd
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Facility Name
Local Institution - 231
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Facility Name
Herlev Hospital
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Facility Name
Local Institution - 232
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Facility Name
Local Institution - 230
City
Odense C
ZIP/Postal Code
5000
Country
Denmark
Facility Name
Onk.Dep., Odense Universitets hospital
City
Odense C
ZIP/Postal Code
5000
Country
Denmark
Facility Name
Local Institution - 240
City
Tampere
State/Province
Oulun Lääni
ZIP/Postal Code
FI-33520
Country
Finland
Facility Name
Helsingin yliopistollinen keskussairaala
City
Helsinki
ZIP/Postal Code
FI-00290
Country
Finland
Facility Name
Local Institution - 241
City
Helsinki
ZIP/Postal Code
FI-00290
Country
Finland
Facility Name
Tampereen yliopistollinen sairaala
City
Tampere
ZIP/Postal Code
33521
Country
Finland
Facility Name
Local Institution - 242
City
Turku
ZIP/Postal Code
20521
Country
Finland
Facility Name
Turku University Hospital
City
Turku
ZIP/Postal Code
20521
Country
Finland
Facility Name
Center Hospitalier Universitaire d' Angers
City
Angers cedex 09
ZIP/Postal Code
49033
Country
France
Facility Name
Local Institution - 253
City
Angers cedex 09
ZIP/Postal Code
49033
Country
France
Facility Name
Hopital Henri Mondor
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
CHRU de Lille France
City
Lille
ZIP/Postal Code
59037
Country
France
Facility Name
Local Institution - 257
City
Lille
ZIP/Postal Code
59037
Country
France
Facility Name
Hopital Edouard Herriot - Hepato-gastroenterologie
City
Lyon Cedex 3
ZIP/Postal Code
69437
Country
France
Facility Name
Local Institution - 258
City
Lyon Cedex 3
ZIP/Postal Code
69437
Country
France
Facility Name
Hopital prive Jean Mermoz
City
Lyon
ZIP/Postal Code
69008
Country
France
Facility Name
Local Institution - 252
City
Lyon
ZIP/Postal Code
69008
Country
France
Facility Name
Hopital Europeen Georges Pompidou
City
Paris
ZIP/Postal Code
75015
Country
France
Facility Name
Local Institution - 250
City
Paris
ZIP/Postal Code
75015
Country
France
Facility Name
Hopital Saint Antoine
City
Paris
ZIP/Postal Code
75571
Country
France
Facility Name
Hopital Pitie Salpetriere
City
Paris
ZIP/Postal Code
75651
Country
France
Facility Name
Local Institution - 259
City
Paris
ZIP/Postal Code
75651
Country
France
Facility Name
CHU La Miletrie
City
Poitiers Cedex
ZIP/Postal Code
86021
Country
France
Facility Name
Local Institution - 251
City
Poitiers Cedex
ZIP/Postal Code
86021
Country
France
Facility Name
Local Institution - 256
City
Toulose
ZIP/Postal Code
31059
Country
France
Facility Name
Pole Des Specialites Medicales, Hopital Purpan
City
Toulose
ZIP/Postal Code
31059
Country
France
Facility Name
Klinikum Weiden
City
Bayern
ZIP/Postal Code
92637
Country
Germany
Facility Name
Local Institution - 280
City
Bayern
ZIP/Postal Code
92637
Country
Germany
Facility Name
Charite - Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
12203
Country
Germany
Facility Name
Local Institution - 272
City
Berlin
ZIP/Postal Code
12203
Country
Germany
Facility Name
Local Institution - 278
City
Dresden
ZIP/Postal Code
D-01307
Country
Germany
Facility Name
Universitatsklinikum Carl Gustav Carus an der TU Dresden
City
Dresden
ZIP/Postal Code
D-01307
Country
Germany
Facility Name
Kliniken Essen-Mitte
City
Essen
ZIP/Postal Code
45136
Country
Germany
Facility Name
Local Institution - 277
City
Frankfurt
ZIP/Postal Code
60590
Country
Germany
Facility Name
Universitatsklinkum Frankfurt
City
Frankfurt
ZIP/Postal Code
60590
Country
Germany
Facility Name
Local Institution - 284
City
Frechen
ZIP/Postal Code
50226
Country
Germany
Facility Name
Praxis Internistischer Onkologie und Hamatologie Frechen
City
Frechen
ZIP/Postal Code
50226
Country
Germany
Facility Name
Local Institution - 275
City
Friedrichshafen
ZIP/Postal Code
88045
Country
Germany
Facility Name
Praxis für Innere Medizin, Dr.Oettle Helmut
City
Friedrichshafen
ZIP/Postal Code
88045
Country
Germany
Facility Name
Ernst-Moritz-Arndt-Universität Greifswald
City
Greifswald
ZIP/Postal Code
17487
Country
Germany
Facility Name
Local Institution - 279
City
Greifswald
ZIP/Postal Code
17487
Country
Germany
Facility Name
Local Institution - 273
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Universitaetsklinik Hamburg - Eppendorf
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Local Institution - 281
City
Köln
ZIP/Postal Code
50674
Country
Germany
Facility Name
Praxis Internistischer Onkologie und Hamatologie Koln
City
Köln
ZIP/Postal Code
50674
Country
Germany
Facility Name
Local Institution - 274
City
Magdeburg
ZIP/Postal Code
39108
Country
Germany
Facility Name
Universitatsklinik Magdeburg
City
Magdeburg
ZIP/Postal Code
39108
Country
Germany
Facility Name
Klinikum der Johannes Gutenberg Uniervsitaet ,Haematologie
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Local Institution - 283
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Klinikum der Universitat Munchen-Grosshadern
City
München
ZIP/Postal Code
81377
Country
Germany
Facility Name
Local Institution - 282
City
München
ZIP/Postal Code
81377
Country
Germany
Facility Name
Klinikum Neuperlach
City
München
ZIP/Postal Code
81737
Country
Germany
Facility Name
Local Institution - 276
City
München
ZIP/Postal Code
81737
Country
Germany
Facility Name
Local Institution - 0271
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Facility Name
University of Tubingen
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Facility Name
Local Institution - 270
City
Würzburg
ZIP/Postal Code
97080
Country
Germany
Facility Name
Universitatsklinikum Würzburg
City
Würzburg
ZIP/Postal Code
97080
Country
Germany
Facility Name
Local Institution - 601
City
Hong Kong
ZIP/Postal Code
0
Country
Hong Kong
Facility Name
Queen Mary Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Tuen Mun Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Local Institution - 602
City
Sha Tin
ZIP/Postal Code
0
Country
Hong Kong
Facility Name
Prince of Wales Hospital the Chinese University of Hong Kong
City
Sha Tin
Country
Hong Kong
Facility Name
Fovarosi Szent Istvan es Szent Laszlo Korhaz es Rendelointezet
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
Facility Name
Local Institution - 293
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
Facility Name
Local Institution - 291
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
Facility Name
Uzsoki Utcai Korhaz
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
Facility Name
Debreceni Egyetem Orvos- es Egeszsegtudomanyi Centrum
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Local Institution - 290
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Local Institution - 292
City
Gyor
ZIP/Postal Code
9024
Country
Hungary
Facility Name
Petz Aladar Megyei Oktato Korhaz,II. Belgyogyaszat
City
Gyor
ZIP/Postal Code
9024
Country
Hungary
Facility Name
Local Institution - 295
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Szent-Gyorgyi Albert TE AOK Borgyogy
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
City
Szolnok
ZIP/Postal Code
5004
Country
Hungary
Facility Name
Local Institution - 311
City
Cork
ZIP/Postal Code
T12 DFK4
Country
Ireland
Facility Name
Cork University Hospital
City
Cork
Country
Ireland
Facility Name
Local Institution - 310
City
Dublin 4
ZIP/Postal Code
4
Country
Ireland
Facility Name
St Vincent's University Hospital
City
Dublin 4
ZIP/Postal Code
4
Country
Ireland
Facility Name
Local Institution - 329
City
Terni
State/Province
Umbria
ZIP/Postal Code
05100
Country
Italy
Facility Name
Local Institution - 325
City
Ancona
ZIP/Postal Code
60020
Country
Italy
Facility Name
Ospedali Riuniti Umberto I GM Lancisi
City
Ancona
ZIP/Postal Code
60020
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Local Institution - 330
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Careggi
City
Firenze
ZIP/Postal Code
50134
Country
Italy
Facility Name
Local Institution - 328
City
Firenze
ZIP/Postal Code
50134
Country
Italy
Facility Name
Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori (I.R.S.T.)
City
Meldola
ZIP/Postal Code
47014
Country
Italy
Facility Name
Local Institution - 331
City
Meldola
ZIP/Postal Code
47014
Country
Italy
Facility Name
Local Institution - 321
City
Milano
ZIP/Postal Code
20132
Country
Italy
Facility Name
Ospedale San Raffaele S.r.l.
City
Milano
ZIP/Postal Code
20132
Country
Italy
Facility Name
Azienda Ospedaliera Niguarda Ca Granda
City
Milano
ZIP/Postal Code
20162
Country
Italy
Facility Name
Local Institution - 322
City
Milano
ZIP/Postal Code
20162
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Pisana
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
Local Institution - 324
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
Arcispedale Santa Maria Nuova
City
Reggio Emilia
ZIP/Postal Code
42100
Country
Italy
Facility Name
Local Institution - 333
City
Reggio Emilia
ZIP/Postal Code
42100
Country
Italy
Facility Name
Local Institution - 323
City
Roma
ZIP/Postal Code
00144
Country
Italy
Facility Name
Local Institution - 327
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Policlinico Universitario Agostino Gemelli
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Istituto Nazionale Tumori Regina Elena
City
Roma
ZIP/Postal Code
144
Country
Italy
Facility Name
Istituto Clinico Humanitas
City
Rozzano (MI)
ZIP/Postal Code
20089
Country
Italy
Facility Name
Local Institution - 326
City
Rozzano (MI)
ZIP/Postal Code
20089
Country
Italy
Facility Name
IRCCS Casa Sollievo della Sofferenza
City
San Giovanni Rotondo
ZIP/Postal Code
71013
Country
Italy
Facility Name
Local Institution - 332
City
San Giovanni Rotondo
ZIP/Postal Code
71013
Country
Italy
Facility Name
Azienda Ospedaliera S Maria di Terni
City
Terni
ZIP/Postal Code
05100
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Integrata di Verona
City
Verona
ZIP/Postal Code
37134
Country
Italy
Facility Name
Local Institution - 320
City
Verona
ZIP/Postal Code
37134
Country
Italy
Facility Name
Local Institution - 641
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Local Institution - 642
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
138-736
Country
Korea, Republic of
Facility Name
Local Institution - 640
City
Seoul
ZIP/Postal Code
138-736
Country
Korea, Republic of
Facility Name
Academisch Medisch Centrum Amsterdam
City
Amsterdam
ZIP/Postal Code
1105
Country
Netherlands
Facility Name
Local Institution - 400
City
Amsterdam
ZIP/Postal Code
1105
Country
Netherlands
Facility Name
Catharina Hospital
City
Eindhoven
ZIP/Postal Code
5632 EJ
Country
Netherlands
Facility Name
Local Institution - 403
City
Eindhoven
ZIP/Postal Code
5632 EJ
Country
Netherlands
Facility Name
Isala Klinieken
City
Zwolle
ZIP/Postal Code
8011
Country
Netherlands
Facility Name
Local Institution - 402
City
Zwolle
ZIP/Postal Code
8011
Country
Netherlands
Facility Name
Centro Hospitalar de Lisboa Central - Hospital de Santo António dos Capuchos
City
Lisboa
ZIP/Postal Code
1069-639
Country
Portugal
Facility Name
Local Institution - 340
City
Lisboa
ZIP/Postal Code
1069-639
Country
Portugal
Facility Name
Hospital Da Luz
City
Lisboa
ZIP/Postal Code
1500-650
Country
Portugal
Facility Name
Local Institution - 341
City
Lisboa
ZIP/Postal Code
1500-650
Country
Portugal
Facility Name
Hospital de Sao Joao
City
Porto
ZIP/Postal Code
4200
Country
Portugal
Facility Name
Local Institution - 342
City
Porto
ZIP/Postal Code
4200
Country
Portugal
Facility Name
Local Institution - 610
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
National University Hospital
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
Local Institution - 611
City
Singapore
ZIP/Postal Code
169-610
Country
Singapore
Facility Name
National Cancer Center
City
Singapore
ZIP/Postal Code
169-610
Country
Singapore
Facility Name
Local Institution - 371
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
Facility Name
Local Institution - 360
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Clinic Barcelona Hospital Universitari
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Local Institution - 363
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Instituto Catalan de Oncologia-Hospital Duran
City
Barcelona
ZIP/Postal Code
08907
Country
Spain
Facility Name
Local Institution - 370
City
Barcelona
ZIP/Postal Code
08907
Country
Spain
Facility Name
Hospital Universitari Vall d'Hebron
City
Barcelona
ZIP/Postal Code
8035
Country
Spain
Facility Name
Hospital General Gregorio Maranon
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Local Institution - 367
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Local Institution - 362
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Ramon y Cajal Univeresity Hospital
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital Clinico San Carlos
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Local Institution - 372
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital 12 de Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Local Institution - 365
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Centro Integral
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Facility Name
Local Institution - 361
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Facility Name
Hospital General Carlos Haya
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Local Institution - 369
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Complejo Hospitalario de Navarra
City
Pamplona/ Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
Local Institution - 368
City
Pamplona/ Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
Hospital Universitario Marques de Valdecilla
City
Santander
ZIP/Postal Code
39008
Country
Spain
Facility Name
Hospital Clinico Universitario De Santiago De Compostela
City
Santiago De Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Local Institution - 366
City
Santiago De Compostela
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Virgen del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Local Institution - 364
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Local Institution - 620
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
Taichung Veterans General Hospital
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
Local Institution - 625
City
Tainan, Taiana
ZIP/Postal Code
704
Country
Taiwan
Facility Name
National Cheng Kung University Hospital
City
Tainan, Taiana
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Local Institution - 623
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Tri-Service General Hospital
City
Taipei
ZIP/Postal Code
11490
Country
Taiwan
Facility Name
Local Institution - 622
City
Taipei
ZIP/Postal Code
114
Country
Taiwan
Facility Name
Chang Gung Medical Foundation-Linkou Branch
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Local Institution - 624
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Local Institution - 621
City
Tapei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
National Taiwan University Hospital
City
Tapei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
Addenbrookes Hospital
City
Cambridge
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Facility Name
Local Institution - 382
City
Cambridge
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Facility Name
Glasgow Royal Infirmary
City
Glasgow
ZIP/Postal Code
G11 6NT
Country
United Kingdom
Facility Name
Local Institution - 380
City
Glasgow
ZIP/Postal Code
G11 6NT
Country
United Kingdom
Facility Name
Weston Park Hospital
City
Sheffield South Yorkshire
ZIP/Postal Code
S10 2SS
Country
United Kingdom
Facility Name
Local Institution - 381
City
Sheffield
ZIP/Postal Code
S10 2SJ
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
29932294
Citation
Young R, Mainwaring P, Clingan P, Parnis FX, Asghari G, Beale P, Aly A, Botteman M, Romano A, Ferrara S, Margunato-Debay S, Harris M. nab-Paclitaxel plus gemcitabine in metastatic pancreatic adenocarcinoma: Australian subset analyses of the phase III MPACT trial. Asia Pac J Clin Oncol. 2018 Oct;14(5):e325-e331. doi: 10.1111/ajco.12999. Epub 2018 Jun 22.
Results Reference
background
PubMed Identifier
30149366
Citation
Reni M, Zanon S, Balzano G, Passoni P, Pircher C, Chiaravalli M, Fugazza C, Ceraulo D, Nicoletti R, Arcidiacono PG, Macchini M, Peretti U, Castoldi R, Doglioni C, Falconi M, Partelli S, Gianni L. A randomised phase 2 trial of nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in locally advanced or borderline resectable pancreatic adenocarcinoma. Eur J Cancer. 2018 Oct;102:95-102. doi: 10.1016/j.ejca.2018.07.007. Epub 2018 Aug 24.
Results Reference
background
PubMed Identifier
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Nab-paclitaxel and Gemcitabine vs Gemcitabine Alone as Adjuvant Therapy for Patients With Resected Pancreatic Cancer (the "Apact" Study)

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