NAC Effect on Infertile Women With Endometrioma
Female Infertility, Endometrioma, Stress Oxidative
About this trial
This is an interventional supportive care trial for Female Infertility focused on measuring en
Eligibility Criteria
Inclusion Criteria:
- Age between 20 and 42 years
- Ultrasound or laparoscopic diagnosis of moderate to sever endometrioma (endometriosis stage III and IV)
- Serum AMH levels between 0.7 and 4.5 ng/ml
- Standard long GnRH and antagonist ovulation stimulation cycle
- Body mass index (BMI) <30 kg/m2
Exclusion Criteria:
- Non-inclusion criteria: Congenital uterine malformations
- Severe male infertility (TESE, PESA)
- Past medical history of asthma
Sites / Locations
- Royan InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
N-acetyl cystein
effervescent placebo
Seventy participants who randomly assigned in the intervention group, during 6 weeks simultaneous to start standard long agonist protocol or antagonist induction, will be received 1200 (2×600) mg of effervescent tablets of NAC daily. Plasma blood will collect before the intervention and at the time of oocyte retrieval (end of 6 week), in addition to, follicular fluid will be obtained from the mature follicles. Also, we will measure severity of dysmenorea by visual analogue scale (VAS) technique.
Seventy participants who randomly assigned to the control group, during 6 weeks simultaneous to start the standard long agonist protocol, or antagonist induction, will be received 1200 (2×600) mg of effervescent placebo tablets daily. Plasma blood will collect before the intervention and at the time of oocyte retrieval, in addition to, follicular fluid will be obtained from the mature follicles. Also, we measure severity of dysmenorrhea by visual analogue scale (VAS) technique.