Back to resultsNeuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise
Primary Purpose
Healthy
Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
running during 24 hours without sleep
no sleeping
Sponsored by
About this trial
This is an interventional health services research trial for Healthy focused on measuring Running during 24 hours, Voluntary evoked force on the muscles, Electrically evoked force on the muscles, EMG activity, Muscle biopsy, subjects will be recruited among experienced ultra-runners
Eligibility Criteria
Inclusion Criteria:
- The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer.
- The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years.
Exclusion Criteria:
The subjects will not be selected if:
- they were injured in the 3 months before the experiment
- they had a tendon or joint pathology that could impair strength measurements.
- they participate to an other experiment at the same time
Sites / Locations
- Pr André GEYSSANT
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
1
2
Arm Description
patients running during 24 hours without sleep
patients without sleep during 24 hours
Outcomes
Primary Outcome Measures
-Voluntary and electrically evoked forces on the contracted muscles
Secondary Outcome Measures
Electrically evoked forces on the relaxed muscles and associated EMG activity
Blood samples before the exercise
Muscle biopsy (vastus lateralis)
Full Information
NCT ID
NCT00428779
First Posted
January 29, 2007
Last Updated
June 10, 2009
Sponsor
Centre Hospitalier Universitaire de Saint Etienne
1. Study Identification
Unique Protocol Identification Number
NCT00428779
Brief Title
Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise
Official Title
Neuromuscular and Cognitive Fatigue During a 24h Treadmill Running Exercise.
Study Type
Interventional
2. Study Status
Record Verification Date
June 2009
Overall Recruitment Status
Completed
Study Start Date
September 2007 (undefined)
Primary Completion Date
December 2007 (Actual)
Study Completion Date
December 2007 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Centre Hospitalier Universitaire de Saint Etienne
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.
Detailed Description
For that purpose, 14 subjects running 24 hours on a treadmill will be compared with a control group being awake during the same period. Subjects who running will have electrically evoked forces on the muscles associated EMG activity, blood samples and muscle biopsy.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Healthy
Keywords
Running during 24 hours, Voluntary evoked force on the muscles, Electrically evoked force on the muscles, EMG activity, Muscle biopsy, subjects will be recruited among experienced ultra-runners
7. Study Design
Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
30 (Actual)
8. Arms, Groups, and Interventions
Arm Title
1
Arm Type
Experimental
Arm Description
patients running during 24 hours without sleep
Arm Title
2
Arm Type
Placebo Comparator
Arm Description
patients without sleep during 24 hours
Intervention Type
Procedure
Intervention Name(s)
running during 24 hours without sleep
Intervention Description
patients running during 24 hours without sleep
Intervention Type
Other
Intervention Name(s)
no sleeping
Intervention Description
patients without sleep during 24 hours
Primary Outcome Measure Information:
Title
-Voluntary and electrically evoked forces on the contracted muscles
Time Frame
24 hours
Secondary Outcome Measure Information:
Title
Electrically evoked forces on the relaxed muscles and associated EMG activity
Time Frame
24 hours
Title
Blood samples before the exercise
Time Frame
every 4 hours
Title
Muscle biopsy (vastus lateralis)
Time Frame
before and after the exercise
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer.
The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years.
Exclusion Criteria:
The subjects will not be selected if:
they were injured in the 3 months before the experiment
they had a tendon or joint pathology that could impair strength measurements.
they participate to an other experiment at the same time
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
DENIS Christian, Professor
Organizational Affiliation
Service de médecine du sport, CHU SAINT-ETIENNE
Official's Role
Study Chair
Facility Information:
Facility Name
Pr André GEYSSANT
City
Saint-etienne
ZIP/Postal Code
42055
Country
France
12. IPD Sharing Statement
Citations:
PubMed Identifier
18841378
Citation
Morin JB, Samozino P, Feasson L, Geyssant A, Millet G. Effects of muscular biopsy on the mechanics of running. Eur J Appl Physiol. 2009 Jan;105(2):185-90. doi: 10.1007/s00421-008-0888-2. Epub 2008 Oct 8.
Results Reference
result
PubMed Identifier
22345427
Citation
Jamart C, Francaux M, Millet GY, Deldicque L, Frere D, Feasson L. Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running. J Appl Physiol (1985). 2012 May;112(9):1529-37. doi: 10.1152/japplphysiol.00952.2011. Epub 2012 Feb 16.
Results Reference
derived
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Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise
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