Neurophysiologic Signatures of Trigeminal Neuralgia Pain
Trigeminal Neuralgia (TN)
About this trial
This is an interventional treatment trial for Trigeminal Neuralgia (TN) focused on measuring transcranial electrical stimulation (tES)
Eligibility Criteria
Inclusion Criteria:
- Healthy subjects who have been diagnosed with trigeminal neuralgia (TN) pain (ASA status 1, 2, or 3).
- Subjects diagnosed with TN pain must have average pain in the moderate to severe (Visual Analog Scale (VAS) of 30-100 mm) range. These subjects will be asked to stop their current medications for 24 hours prior to their scan.
- Patients diagnosed with classical trigeminal neuralgia, type 1 [TN1, G50.00], or symptomatic trigeminal neuralgia [TN2, G53.80] according to the International Classification of Headache (IHS) Disorders criteria (7).
Exclusion Criteria:
- Patients diagnosed with post-herpetic neuralgia, trigeminal neuropathic pain, and trigeminal deafferentation pain.
- TN subjects with ASA status 4-5 and Emergency operation.
- Presence of chronic disease (e.g. cardiovascular disease, liver disease, kidney disease, diabetes, etc.), other than trigeminal neuralgia.
- Pregnant females
Sites / Locations
- UF Health Shands Hospital
- McKnight Brain Institute
Arms of the Study
Arm 1
Experimental
Trigeminal Neuralgia Pain Diagnosis
Healthy patients between the ages of 18-75 who have been diagnosed with moderate to severe Trigeminal Neuralgia Pain. The study team will perform transcranial electrical brain stimulation using either electrodes that are in the form of two salt-water soaked sponges attached to the head or a set of smaller gel-covered disk electrodes that fit inside the electrode holders of the EEG cap. During stimulation a weak direct or alternating current will be passed through the stimulating electrodes. Stimulation may last 20 to 30 minutes.