Neurophysiological Evaluation of Schizophrenia Patients After Cognitive and Physical Intervention

A Neurophysiological Investigation of the Effectiveness of Web-based Exergaming Platform of Cognitive and Physical Training in Schizophrenic Patients

24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. Each session consisted of 45 minutes of cognitive traing (BrainHQ platform https://www.brainhq.com/) and 45 minutes of physical training (FitForAll platform https://www.fitforall.gr/play/app/). Cognitive training included memory, attention, velocity, intelligence etc. Physical training included aerobic, strength flexibility and other excercises. All evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. Neurophysiological evaluation consisted of EEG with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. Neuropsychological evaluation included Trail Making Test (A & B), Verbal Fluency, Stroop test, Wechsler Memory - Cubes (visuospatial), MoCA, FAB (Screening for frontal damage) and Eyes Test (Theory of Mind). Also, the physical condition evaluation included 6-Minute Walking Distance (6MWD), ΒΜΙ, HandGrip Strength Test, Short Physical Performance Battery Protocol.

24 sessions (8 weeks, 3 times per week) of computer based 45 minute cognitive and 45 minute physical training.

Alterations in functional connectivity properties and on the organization of resting state networks quantified through graph theory tools. These measures would be measured through high-density electroencephalographic (EEG) evaluation and reconstruction of cortical activity.

Inclusion Criteria: a diagnosis of schizophrenia disorder according to ICD10 criteria clinically stable patients (no recent change in psychotropic medication except benzodiazepines) sufficient acculturation and fluency in Greek language assent of the attending physician for participation in the study Exclusion Criteria: co-morbidity with neurological disorders (e.g.epilepsy) or head injury a pathological or other somatic disorder that contraindicate physical exercise alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco) abstainance from intervention for more than 12 days cognitive decline treated with Benzodiazepine

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