Neurostimulation for Respiratory Function After Spinal Cord Injury
Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
About this trial
This is an interventional treatment trial for Spinal Cord Injuries focused on measuring Neural plasticity, Spinal cord injury, Diaphragm, Respiratory training, Spike-timing-dependent plasticity, Neurostimulation
Eligibility Criteria
Inclusion Criteria: Male and females between ages 18-85 years SCI at least 6 months post-injury Spinal Cord injury at C1-C5 Demonstrate respiratory deficit following spinal cord injury as following: (1) Individuals using mechanical ventilation, and (2) individuals with pulmonary function testing (PFT) deficits corresponding to having a vital capacity (VC) < 80% (predicted) Must have a family member or caregiver who is trained and willing to operate the mechanical ventilator during study visits. Exclusion Criteria: Any illness or condition that based on the research team's assessment, will compromise with the participant's ability to comply with the protocol, patient safety, or the validity of the data collected during this study. Any debilitating disease prior to the SCI that caused exercise intolerance. Individuals entirely dependent on the support of a diaphragmatic pacer (24 hours per day). Premorbid, ongoing major depression or psychosis, altered cognitive status. History of head injury or stroke Vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication History of seizures or epilepsy Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold Pregnant females If a woman of childbearing age is unsure of the pregnancy, and does not want to take the pregnancy test Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk Metal plate in skull Individuals with scalp shrapnel, cochlear implants, or aneurysm clips Individuals taking Bupropion, Dolutegravir, Lacosamide, Trilaciclib, or PR Interval prolonging drugs
Sites / Locations
- Shirley Ryan Ability LabRecruiting
Arms of the Study
Arm 1
Experimental
Neurostimulation for respiratory function after spinal cord injury
Efficacy of STDP on respiratory function.