Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children
HIV Infections, Cryptosporidiosis
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Nitazoxanide, Antiprotozoal Agents, Cryptosporidiosis, Cryptosporidium parvum, AIDS-Related Opportunistic Infections, Pharmacokinetics, Drug Adminstration Schedule
Eligibility Criteria
Inclusion Criteria for Step 1: HIV infected Chronic diarrhea with 3 or more bowel movements per day for at least 5 days in the 2 weeks prior to study entry OR 2 or more bowel movements per day for at least 5 days in the 2 weeks prior to study entry if accompanied by dehydration Documented presence of C. parvum oocysts in stool Weight of 4.0 kg (8.8 lbs) or more AND less than or equal to the maximum weight for age group as specified in the study protocol Parent or guardian willing to provide informed consent, if applicable Willing to use acceptable forms of contraception Exclusion Criteria for Step 1: Inability to take liquid or tablet form of medication Serum transaminase (ALT) and bilirubin greater than or equal to 5 times the upper limit of normal at study screening Active M. avium intracellulare or cytomegalovirus (CMV) colitis Active cancer Certain medications Pregnant or breastfeeding
Sites / Locations
- Stellenbosch Univ. CRS
- Siriraj Hospital Mahidol University CRS