NOGA Angiogenesis Revascularization Therapy: Evaluation by RadioNuclide Imaging - The Northern Trial
Myocardial Ischemia
About this trial
This is an interventional treatment trial for Myocardial Ischemia focused on measuring angiogenesis, VEGF
Eligibility Criteria
Inclusion Criteria: Canadian Cardiovascular Class III-IV angina despite treatment with maximal medical therapy LVEF>20% Ischemic defects on myocardial stress SPECT imaging Exclusion Criteria: NYHA>2 History of or diagnosis of age related macular degeneration, retinopathy Atrial fibrillation Primary valvular heart disease Evidence of or known history of cancer with in past 10 yea Uncontrolled hypertension Liability to receive dipyridamole History or diagnosis of rheumatoid arthritis Recent MI(within 4 weeks) Important ilio-femoral peripheral vascular disease, limiting catheter access History of unexplained gastrointestinal hemorrhage with the past 5 years LV thrombus visualized by either echocardiography or contrast LV angiogram Other severe concurrent illnesses
Sites / Locations
- University of Alberta
- Victoria Heart Institute Foundation
- Sunnybrook Health Sciences Centre
- St. Michael's Hospital
- Mount Sinai
- Montreal Heart Institute
- Institute de Cardiologie, Hopital Laval