Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations
Acute Appendicitis
About this trial
This is an interventional treatment trial for Acute Appendicitis
Eligibility Criteria
Inclusion Criteria: Age ≥18 years Able to consent for the study Diagnosis of acute appendicitis confirmed by CT imaging Exclusion Criteria: Appendicolith/fecalith on imaging Chronic or recurrent appendicitis Having received prior antibiotic treatment for other reasons within 5 days prior to study enrollment Hemodynamically abnormal (SBP<90 mmHg, Heart Rate (HR) >120, mmHg, Partial Pressure of Oxygen in Arterial Blood (PaO2<60), or potential of Hydrogen (pH<7.3)). Inability to tolerate general anesthesia (determined by surgery and anesthesiology teams)
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Operative Arm
Non-Operative Arm
Operation (laparoscopic appendectomy) will be performed to remove appendix.
No operation will be performed, and instead, will receive intra-venous (IV) antibiotics, transitioned to by mouth (oral) antibiotics