Oleocanthal Rich Olive Oil Acute Effects on Hyperglycemia and Platelet Activation in T2DM
Diabetes Mellitus, Adult-Onset, Platelet Dysfunction, Postprandial Hyperglycemia
About this trial
This is an interventional other trial for Diabetes Mellitus, Adult-Onset focused on measuring type 2 diabetes mellitus, diabetic platelet, platelet aggregation, oxidative stress, inflammation, postrpandial, hyperglycemia, extra virgin olive oil, oleocanthal, polyphenols, dyslipidemia
Eligibility Criteria
Inclusion Criteria:
- adult patients diagnosed with T2DM
- stable weight the last two months
- smokers or not
- no restriction regarding the menopause
Exclusion Criteria:
- insulin therapy
- antiplatelet, anti-coagulant, anti-inflammatory and anti-depressant medication
- chronic inflammatory disease
- autoimmune diseases
- cancer
- uncontrolled thyroid disease.
- supplement consumption the last two months
Sites / Locations
- Department of Nutrition and Dietetics, Harokopio UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
Control
Positive control
Refined olive oil
EVOO with moderate concentration of oleocanthal
EVOO with high concentration of oleocanthal
100g white bread plus 40ml butter
100g white bread plus 40ml butter and 400mg ibuprofen
100g white bread plus 40ml refined olive oil
100g white bread plus 40ml EVOO containing 250 mg/kg oleocanthal
100g white bread plus 40ml EVOO containing 500 mg/kg oleocanthal